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NAD+ Nasal Spray
Longevity (Rx)

NAD+ Nasal Spray

Non-invasive NAD+, no needles required.

NAD+ nasal spray aims to deliver the coenzyme through the nasal lining without an injection. It is not FDA-approved for any use, and human absorption through this route hasn't been measured; the supporting evidence is limited to a rat stroke model.

Nasal spray300 mg/mL

Purchase type

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Cadence

NAD+ Nasal Spray Monthly Plan$134 billed monthly
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How it works

How NAD+ Nasal Spray works

NAD+ is a coenzyme every cell uses for fundamental processes, including ATP production, sirtuin activity, and PARP-driven repair pathways central to mitochondrial function. This nasal spray is formulated to deliver NAD+ across the nasal mucosa as a non-injectable alternative to IV delivery. Human absorption and bioavailability through this route are not yet measured.

What to expect

Timeline & results

Because there's no human pharmacokinetic data for nasal NAD+, onset and absorption in people haven't been measured. The supporting evidence for this delivery route comes from a rat stroke model, not human trials, so what to expect from regular use isn't established in controlled human research.

Getting started

Care that fits your life

01

Complete a quick online visit

Answer a few health questions, 100% online, no appointment needed.

02

A licensed provider reviews

If it's right for you, a US-licensed provider writes the prescription.

03

Delivered free & discreet

Your treatment ships to your door in plain packaging, with ongoing support.

Key benefits

What NAD+ Nasal Spray is used for

No needles, a non-invasive way to take NAD+.

Aims to bypass poor oral NAD+ absorption.

A different delivery route than IV or precursor pills.

Simple to use as part of a provider-guided routine.

Safety information

Important safety information

The most commonly reported side effects are nasal irritation, rhinitis, and headache. Use caution with severe liver or kidney disease, an active infection, uncontrolled diabetes, or severe cardiovascular disease, and discuss these with your provider before starting. NAD+ nasal spray is not FDA-approved for any use, and human evidence for this delivery route is limited to an animal stroke model, not human trials. This is a wellness product grounded in early-stage research, not a treatment for any medical condition. This product is compounded by a licensed pharmacy and is not FDA-approved. It has not undergone FDA review for safety or efficacy.

This page is educational and is not medical advice. Tell your provider about your full medical history and current medications before starting treatment.

About

About NAD+ Nasal Spray

NAD+ nasal spray delivers nicotinamide adenine dinucleotide across the nasal mucosa, providing an alternative to injectable administration that many individuals find more convenient for ongoing daily use. The nasal route allows the coenzyme to enter circulation while potentially facilitating proximity to central nervous system tissue via olfactory pathways, though the precise pharmacokinetics of nasal NAD+ in humans are still being characterized.

NAD+ is a coenzyme central to cellular energy metabolism, DNA repair signaling, and the activity of sirtuins -- a family of proteins that have attracted considerable research attention in the context of aging biology. NAD+ levels decrease with age, and there is growing scientific interest in whether supporting these levels through supplementation may have meaningful effects on cellular health and resilience. The nasal spray formulation offers a high-concentration, low-volume delivery option for daily or as-directed use.

Usage is determined by a licensed provider following an online visit. Typical protocols involve one to several sprays per nostril once or twice daily, adjusted based on individual response and provider guidance. The nasal spray is generally well-tolerated; some users note mild transient nasal irritation. Because it avoids the intravenous or subcutaneous route, it is often considered a practical option for maintenance dosing between periodic injectable sessions.

NAD+ nasal spray may be appropriate for adults who prefer a non-injectable format, those maintaining a longevity protocol established with a provider, or individuals new to NAD+ supplementation who want to begin with a less invasive route. It is not a replacement for evaluation of underlying fatigue or metabolic concerns.

This product is compounded by a licensed 503A pharmacy and dispensed only after a provider review. It is not an FDA-approved drug product. Individual responses to NAD+ supplementation vary, and benefits described in the literature are based on preliminary research.

FAQ

Frequently asked questions

Is NAD+ nasal spray FDA approved?+

No, NAD+ nasal spray is not FDA-approved for any use. It's a compounded product, and the evidence supporting nasal delivery of NAD+ comes from an animal stroke model rather than human trials. It's offered as a wellness product, not as an FDA-approved treatment for any medical condition.

What does NAD+ do in the body?+

NAD+ is a coenzyme every cell relies on for fundamental processes, including ATP production, sirtuin activity, and PARP-driven repair pathways central to mitochondrial function. It's essential to normal cellular biochemistry. Whether nasal delivery meaningfully raises NAD+ levels in humans hasn't been measured in clinical research.

Is nasal or IV NAD+ a better choice?+

Nasal NAD+ avoids needles entirely, applied through the nose, while IV NAD+ is infused directly into the bloodstream and has some limited human safety data behind it. Nasal absorption in humans hasn't been measured; the supporting evidence is from an animal study. Your provider can walk you through what's known about each route.

Is NAD+ nasal spray safe long term?+

Long-term safety in humans hasn't been established for nasal NAD+. There is no human pharmacokinetic or long-term safety data for this delivery route, only an animal stroke model. NAD+ nasal spray is not FDA-approved, and anyone considering ongoing use should discuss the limited evidence with their provider first.

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