Tretinoin + Niacinamide + Hyaluronic Acid

This compounded topical combines prescription-strength tretinoin with two well-characterized supportive actives: niacinamide (vitamin B3) and hyaluronic acid. Tretinoin drives the core mechanism of accelerated cell turnover and collagen stimulation, while niacinamide contributes anti-inflammatory properties and supports the skin's ceramide and barrier function. Hyaluronic acid is a humectant that draws moisture to the skin surface, helping offset the dryness that tretinoin commonly produces. Together these three ingredients are formulated to deliver retinoid-grade renewal with a more tolerable texture and moisture experience than tretinoin alone.

The cream is applied to clean, dry skin in the evening. A thin, even layer across the face is sufficient. Because niacinamide and hyaluronic acid are incorporated directly into the formula, a separate heavy moisturizer may not be necessary for all skin types, though your provider's guidance should take precedence. As with all tretinoin-containing treatments, a retinization period involving temporary flaking, redness, or tightness is common during the first several weeks.

Users may notice improvements in skin hydration and comfort relatively early, while retinoid-driven changes to texture, tone, and fine lines typically require consistent use over three to six months or more. Individual results depend on skin type, the concentration prescribed, and adherence to the recommended regimen. This formulation is available in multiple potencies, selected in collaboration with a licensed provider.

This formula is suited to adults who want the documented benefits of tretinoin but have sensitive, dry, or easily irritated skin, or who have had difficulty tolerating tretinoin alone in the past. Contraindications mirror those of tretinoin: not for use during pregnancy or while breastfeeding, and daily broad-spectrum sun protection is required. Avoid contact with eyes and mucous membranes. Discontinue and contact your provider if significant or prolonged irritation occurs.