What does the video say about any injectable peptide?

Any injectable peptide or compounded drug protocol requires a licensed prescriber, a clinical evaluation, and monitoring. A TikTok video, including this one, cannot replace that process.

Originally posted by @insideout_aesthetics on TikTok · 33s|Watch on TikTok

Full video transcriptClick to expand

Auto-generated transcript of @insideout_aesthetics's video. Quoted here for educational fact-check commentary; original creator retains all rights to the video content.

0:00What dosage do you use or what doses would you suggest?
0:03So there's a lot of different regimens out there
0:06as far as dosage.
0:07My pharmacist suggested that we do 50 units three times a week,
0:13but you've got to work your way up to that.
0:15You start out 20 units, 30 units, 40 units,
0:18and then you go to 50.
0:19I firstly do 40 units four times a week.
0:23And that seems to be where I feel best.
0:26I recover from injuries quicker.
0:29I feel a little bit more energy, easy peasy, three times a week.

@insideout_aesthetics's NAD+ dosing claims, fact-checked

Name: @insideout_aesthetics's NAD+ dosing claims, fact-checked
Uploaded: 2025-06-20T22:19:35.000Z
Duration: 33 s

Inside Out Aesthetics

TikTok creator

122.0K viewsWatch on TikTok →

Quick answer

The creator describes a personal subcutaneous NAD+ injection protocol of 40 units four times per week, ramping up from 20 units, as recommended by their pharmacist. This dosing is expressed in units rather than milligrams, which is atypical for NAD+ preparations and suggests the need for clarification on the concentration of the compounded formulation being used. The claimed benefits of improved recovery and energy are biologically plausible based on NAD+'s role in cellular metabolism, but have not been established in controlled trials for subQ NAD+ specifically in healthy adults.

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This page currently connects to 6 source-backed evidence items through visible references or structured citation data.

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For @insideout_aesthetics's NAD+ dosing claims, fact-checked, FormBlends checks the page topic against primary trials, systematic reviews, guidelines, and current PubMed-indexed literature where available. These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient.

ReviewNAD+ and precursor evidence2021

NAD+ metabolism and its roles in cellular processes during ageing

Core review for NAD+ decline, mitochondrial function, DNA repair, and aging biology.

PubMed

Randomized trialNAD+ and precursor evidence2021

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Human NMN source for metabolic claims while keeping population limits clear.

PubMed

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Page-specific review note

What this exact clip is really saying

This FormBlends review is specific to "@insideout_aesthetics's NAD+ dosing claims, fact-checked" from Inside Out Aesthetics. We read the clip as a Peptide social video fact-checks claim about NAD+ Peptide Complex, then separate the useful signal from what a short social video cannot prove. The page-specific claim focus is: The creator describes a personal subcutaneous NAD+ injection protocol of 40 units four times per week, ramping up from 20 units, as recommended by their pharmacist.

The reason this review is not generic is the source wording and the canonical claim label "peptides when it comes to nad and peptide protocols dosing varies." In this clip, the useful excerpt is: "What dosage do you use or what doses would you suggest?" That wording changes the review because it points to NAD+ Peptide Complex safety, access, evidence, and fit, not a one-size-fits-all protocol.

The source trail for this page is checked against NAD+ metabolism and its roles in cellular processes during ageing (2021), Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women (2021), and Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults (2018), plus the creator's own wording. NAD+ Peptide Complex still needs an eligibility review, medication-interaction screen, access check, and quality-control review before anyone treats a social clip as medical advice.

NAD+ precursor studies (Elhassan et al.

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The strongest next step is to compare the claim with FormBlends' NAD+ Peptide Complex guide, evidence notes, and provider review path before acting.

Claim verdict

The useful answer behind this video

This page is built to answer the specific claim behind the clip, then separate what is useful from what still needs clinical context. That makes the URL more than a repost: it gives Google, readers, and AI retrieval systems a concise verdict with source and safety boundaries.

Claim being checked

The creator describes a personal subcutaneous NAD+ injection protocol of 40 units four times per week, ramping up from 20 units, as recommended by their pharmacist.

FormBlends verdict

NAD+ Peptide Complex safety, access, evidence, and fit

Evidence strength

Source-backed review with clinical or regulatory citations.

Patient-safe next step

Compare the claim with the NAD+ Peptide Complex guide, safety notes, access rules, and a licensed-provider review.

What to do with this video

Use the clip as a claim to verify, not a treatment plan

What it helps with

The creator describes a personal subcutaneous NAD+ injection protocol of 40 units four times per week, ramping up from 20 units, as recommended by their pharmacist. This dosing is expressed in units rather than milligrams, which is atypical for NAD+ preparations and suggests the need for clarification on the concentration of the compounded formulation being used. The claimed benefits of improved recovery and energy are biologically plausible based on NAD+'s role in cellular metabolism, but have not been established in controlled trials for subQ NAD+ specifically in healthy adults.
Subcutaneous NAD+ is a compounded preparation with no FDA-approved equivalent, meaning quality and concentration vary by pharmacy and cannot be assumed consistent.
NAD+ precursor studies (Elhassan et al., 2019, Cell Reports; Dollerup et al., 2018, Nature Communications) confirmed blood NAD+ can be raised through supplementation, but these used oral NR in older adults, not injected NAD+ in healthy adults.

What it may miss

It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
NAD+ Peptide Complex decisions still need source quality, legal access, and provider oversight checks.
Social video captions rarely show the full evidence base behind a claim.

Best next step

Compare the claim against the NAD+ Peptide Complex guide, cost path, safety notes, and provider review before acting.

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What You'll Learn

Subcutaneous NAD+ is a compounded preparation with no FDA-approved equivalent, meaning quality and concentration vary by pharmacy and cannot be assumed consistent.
NAD+ precursor studies (Elhassan et al., 2019, Cell Reports; Dollerup et al., 2018, Nature Communications) confirmed blood NAD+ can be raised through supplementation, but these used oral NR in older adults, not injected NAD+ in healthy adults.
Expressing NAD+ doses in 'units' rather than milligrams is nonstandard. Patients should confirm the exact milligram concentration of any compounded NAD+ formulation before injecting.
The ramp-up titration approach described in the video is clinically reasonable for minimizing side effects, but the specific dose numbers (20, 30, 40, 50 units) are not validated by any published dosing protocol.
IV NAD+ infusions at 300mg and above carry a documented side effect profile including nausea, flushing, chest tightness, and cardiovascular stress, none of which were mentioned in this video.
Injury recovery claims for NAD+ are biologically speculative in humans. The mechanistic link through sirtuins and PARP enzymes is real, but no human RCT has tested subQ NAD+ for this specific outcome.
Any injectable peptide or compounded drug protocol requires a licensed prescriber, a clinical evaluation, and monitoring. A TikTok video, including this one, cannot replace that process.

Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team · This is not a transcript. It is our independent review of the video above.

What did @insideout_aesthetics actually say?

The creator recommended a NAD+ subcutaneous injection protocol based on personal experience and a pharmacist's suggestion. In their words, they do "40 units four times a week" and find that dose is "where I feel best." They also described a ramp-up approach: starting at 20 units, progressing through 30 and 40, before reaching 50 units three times a week, which the pharmacist recommended. They credited this protocol with helping them "recover from injuries quicker" and feel "a little bit more energy."

To be clear about what this is: one person sharing their personal dosing experience at a medspa, framed as general guidance. No patient population is specified. No underlying condition is mentioned. No adverse effects are discussed. That framing matters, because 122,000 people watched this video, and some of them are likely taking notes.

Does the science back this up?

The honest answer is: partially, but with serious caveats. The evidence for NAD+ precursor therapy is real but mostly comes from oral or IV nicotinamide riboside (NR) and NMR studies, not subcutaneous NAD+ injections specifically. The subcutaneous route is used clinically, but it is not well-studied in controlled trials.

Human research on NAD+ supplementation does show increases in blood NAD+ levels. Elhassan et al. (2019, Cell Reports) demonstrated that oral NR raised whole blood NAD+ in older adults. Dollerup et al. (2018, Nature Communications) found similar results with NR in a randomized controlled trial. However, these studies looked at precursors, not direct NAD+ injection. The mechanistic assumption that more circulating NAD+ translates to better energy and faster recovery is biologically plausible, given NAD+'s role in mitochondrial function and DNA repair, but the clinical evidence for those specific outcomes in healthy adults remains thin. Martens et al. (2023, Nature Aging) showed some cardiovascular benefits with NMN in older adults, but that is a different compound and a different population.

What did they get wrong (or right)?

Credit where it is due: the ramp-up approach they describe is actually reasonable. Starting at a lower dose and titrating upward is standard clinical practice for compounds that can cause side effects like flushing, nausea, and injection site reactions. That part is not controversial.

What is more problematic is the confident causal language. Saying the protocol helps "recover from injuries quicker" implies a therapeutic outcome. NAD+ is not FDA-approved for injury recovery. Subcutaneous NAD+ is a compounded preparation, and compounded drugs are not equivalent to any approved formulation. The creator does not mention this. They also do not mention that "units" is an unusual way to measure NAD+ doses. NAD+ is typically dosed in milligrams, not units. Units is a measurement used for insulin and a handful of other biologics. Using that terminology without clarification creates confusion about what is actually being injected and at what concentration.

The claim that 300mg IV NAD+ infusions exist is accurate, those are offered at some clinics, but the video does not address the significant side effect profile of IV NAD+, which includes chest tightness, nausea, and cardiovascular stress at higher infusion rates.

What should you actually know?

NAD+ therapy is a legitimate area of clinical and research interest. The biology is real. The commercial hype, however, has run well ahead of the evidence, and videos like this one can blur that line quickly.

A few things worth knowing before you follow any protocol you saw on TikTok. First, subcutaneous NAD+ injections involve a compounded drug. Compounded drugs vary in concentration, sterility, and quality across pharmacies, which matters a lot when you are injecting something. Second, the "units" framing in this video should prompt you to ask your prescriber exactly what concentration you are receiving. Third, the energy and recovery benefits described here are anecdotal. That does not mean they are false, but it does mean they are not proven in your body, for your goals, at this dose. Fourth, any protocol involving injections requires medical supervision, bloodwork, and a prescriber who knows your full history. A TikTok video cannot substitute for that.

If you are interested in NAD+ therapy, that conversation belongs in a clinical setting, not in a comments section.

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About the Creator

Inside Out Aesthetics · TikTok creator

122.0K views on this video

When it comes to NAD+ and peptide protocols, dosing varies. Many start at 20 units and work up to 40–50 units, 3–5 times per week. Some clinics offer IV NAD infusions up to 300mg. We typically recomm

Frequently asked questions

Quick answers based on this video and our medical team review.

What does the video say about subcutaneous nad+?

Subcutaneous NAD+ is a compounded preparation with no FDA-approved equivalent, meaning quality and concentration vary by pharmacy and cannot be assumed consistent.

What does the video say about nad+ precursor studies (elhassan et al., 2019, cell reports; dollerup?

NAD+ precursor studies (Elhassan et al., 2019, Cell Reports; Dollerup et al., 2018, Nature Communications) confirmed blood NAD+ can be raised through supplementation, but these used oral NR in older adults, not injected NAD+ in healthy adults.

What does the video say about expressing nad+ doses in 'units' rather than milligrams?

Expressing NAD+ doses in 'units' rather than milligrams is nonstandard. Patients should confirm the exact milligram concentration of any compounded NAD+ formulation before injecting.

What does the video say about the ramp-up titration approach described in the video?

The ramp-up titration approach described in the video is clinically reasonable for minimizing side effects, but the specific dose numbers (20, 30, 40, 50 units) are not validated by any published dosing protocol.

What does the video say about iv nad+ infusions at 300mg?

IV NAD+ infusions at 300mg and above carry a documented side effect profile including nausea, flushing, chest tightness, and cardiovascular stress, none of which were mentioned in this video.

What does the video say about injury recovery claims for nad+?

Injury recovery claims for NAD+ are biologically speculative in humans. The mechanistic link through sirtuins and PARP enzymes is real, but no human RCT has tested subQ NAD+ for this specific outcome.

Sources & references

Citations extracted from our medical team's review. Click any citation to search PubMed.

Educational use only. This fact-check is editorial content for general information. Nothing here is medical advice. Talk to a licensed provider about your specific situation before starting, stopping, or changing any supplement, peptide, or medication regimen.