GHK-Cu (Copper Peptide)

GHK-Cu (glycyl-L-histidyl-L-lysine:copper(II)) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine. Plasma levels of GHK-Cu decline from approximately 200 ng/mL at age 20 to 80 ng/mL by age 60, correlating with the decline in regenerative capacity.

Genome-wide analysis has revealed that GHK-Cu modulates the expression of over 4,000 human genes - approximately 6% of the human genome. Remarkably, it shifts gene expression patterns from a disease-associated state toward a healthy state, simultaneously upregulating genes involved in tissue repair while suppressing genes associated with inflammation, fibrosis, and cancer metastasis.

GHK-Cu is one of the most well-studied peptides for skin rejuvenation, with multiple double-blind clinical trials showing improvement in fine lines, skin density, and firmness. But its benefits extend far beyond skin: it promotes bone regeneration, wound healing, and has demonstrated neuroprotective effects.