GLP-1 Side Effect Trial Data Tool
Compare the side effect rates reported for named adult study groups in product-label tables.
Semaglutide - Wegovy 2.4 mg
Adult weight-reduction trials: placebo (n=1,261) and Wegovy injection 2.4 mg (n=2,116).
Rates describe events reported during treatment, including escalation. They are not rates at a starting dose or a single week. Unreported entries stay unestimated. Wegovy prescribing information, Table 3. Source checked October 2, 2026.
Smaller meals, slower eating, lower-fat foods, and delayed escalation if needed.
Hydration and provider review if persistent or severe.
Call a clinician for repeated vomiting or dehydration symptoms.
Fluids, fiber as tolerated, movement, and clinician-approved stool softeners.
Track severity and seek care for intense or persistent pain.
Hydration, regular meals, and blood-pressure review if recurring.
Check calorie, protein, fluid, and sleep adequacy.
Avoid large late meals and discuss reflux options with a clinician.
Review hydration, blood pressure, and glucose if applicable.
Reduce trigger foods during escalation weeks.
Rotate sites and avoid irritated areas.
Prioritize protein and fluids early in the day.
Reported Study Groups Comparison
| Side Effect | Placebo | Wegovy 2.4 mg |
|---|---|---|
| Nausea | 16% | 44% |
| Diarrhea | 16% | 30% |
| Vomiting | 6% | 24% |
| Constipation | 11% | 24% |
| Abdominal pain | 10% | 20% |
| Headache | 10% | 14% |
| Fatigue | 5% | 11% |
| Dyspepsia | 3% | 9% |
| Dizziness | 4% | 8% |
| Flatulence | 4% | 6% |
| Injection site reaction | Not reported | Not reported |
| Decreased appetite | Not reported | Not reported |
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Medical Disclaimer: The reported rates shown come from product-label tables for named study populations. Your individual experience may differ. Most GI side effects are mild to moderate and decrease over time with proper titration. Consult your healthcare provider about any side effects you experience.