What did @kianajardot actually say?
Honestly, the transcript here is a mess, and that's not a criticism of the creator, it's just the reality of a reaction video filmed mid-experience. @kianajardot appears to have taken Melanotan II (MT2) and is documenting what sounds like an acute side effect episode in real time. The phrases "forcing of chills" and "I just put my brains out" suggest nausea and possibly vomiting. "Kept on ins for everything" likely refers to keeping it in, meaning they tried to tolerate the injection site discomfort or systemic reaction. This is a first-person adverse event report, not a tutorial. But with 805,000 views, it functions as one whether they intended it to or not.
The implicit claim here is that MT2 produces severe, immediate side effects that are worth documenting on camera. That part, at least, is consistent with the published literature.
Does the science back this up?
Yes, and this is one of those rare cases where a chaotic TikTok reaction actually reflects what clinical pharmacology predicts. MT2 is a synthetic analog of alpha-melanocyte stimulating hormone. It binds to melanocortin receptors, particularly MC1R and MC4R. The MC4R pathway is heavily implicated in the nausea and emesis response, which is exactly why MT2 reliably causes nausea, especially at higher or initial doses.
A double-blind crossover study by Wessells et al. (2000, New England Journal of Medicine) examined MT2 for erectile dysfunction and documented nausea as the most common adverse event, occurring in roughly 32% of subjects. Flushing, yawning, and spontaneous erections were also reported. A later review by King et al. (2007, Drug and Alcohol Dependence) specifically flagged the unregulated use of MT2 purchased online as a significant public health concern, noting that users self-inject a compound with no approved clinical indication, no standardized dosing, and no sterility guarantees. The chills and severe nausea @kianajardot describes are textbook MC4R activation, not a fluke.
What did they get wrong (or right)?
They got the side effect profile right, even if accidentally. What's missing, and this matters given the view count, is any acknowledgment of why those side effects happen or what they signal about the compound's mechanism. "Take MT2 they said it'll be fine" reads as a warning, but without context it also normalizes the idea that powering through a severe nausea episode is just part of the process.
That framing is a problem. MT2 is not approved by the FDA for any indication. It is not a regulated pharmaceutical in the United States. The compound circulating in the peptide community is almost universally sourced from unregulated research chemical suppliers, meaning purity, concentration, and sterility are unverified. A 2019 analysis by Brennan et al. (Clinical Toxicology) tested peptide products purchased online and found significant dosing inaccuracies and contamination in a substantial portion of samples. Treating a severe systemic reaction as a rite of passage, rather than a potential signal to stop, is genuinely dangerous framing regardless of intent.
What should you actually know?
MT2 activates melanocortin receptors that regulate pigmentation, sexual function, and appetite. The nausea and chills depicted in this video are not a sign the compound is working. They are a sign the body is responding to MC4R stimulation in the GI tract and hypothalamus. Some users interpret these symptoms as dose-related and adjust accordingly. That logic has some pharmacological basis, but it assumes the compound is what the label says it is, at the concentration claimed, which with unregulated peptide sources is a significant assumption.
There are also longer-term concerns. Case reports have linked MT2 use to melanocytic nevus changes and atypical mole proliferation (Dobbins et al., 2000, British Journal of Dermatology). The compound has not been studied for long-term safety in human trials. If you are experiencing severe nausea, vomiting, or chills after any peptide injection, stopping and contacting a clinician is the appropriate response, not continuing and filming it.