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Auto-generated transcript of @joe_vito_'s video. Quoted here for educational fact-check commentary; original creator retains all rights to the video content.
- 0:00Alright, this is gonna be my test-affencing update. I want to start off by apologizing
- 0:06Unfortunately for my own personal content. My full-time career is kind of making
- 0:12content for other people
- 0:14So I don't often get to do that for myself
- 0:16But I did kind of realize that there's a couple people who wanted an update and so I wanted to finally give that
- 0:23So at this point I've been taking test-affencing for about a month and a half
- 0:26You typically get like 60 servings in a bottle so I guess you could say I'm three-fourths of the way through the bottle
- 0:32We're done and obviously it's been a lot a lot of times. It's my last update
- 0:39Just like four days in so I'm gonna kind of go through
- 0:42you know everything that I can remember and
- 0:45Tell you really anything I can't update wise than just in general
- 0:48So what I can remember about basically as soon as I got done filming that update video was it definitely got a little worse
- 0:55um
- 0:56dry mouth for sure heart rate definitely increased and
- 1:01Mood was just not good like I had like a really dark couple of days
- 1:05And then at that point I was like a little a little worried
- 1:09But not really because that's not like I had normal for me and I understand that like you know this this
- 1:16Ultimately Amazon to test-affencing isn't gonna like you know
- 1:22Overdo everything right so I knew that there was you know it was likely that I was just feeling you know
- 1:27If he because I was feeling if he and then a couple days after that could things kind of went back to normal
- 1:32I feel so bad anymore, but I feel great
- 1:35Let's also keep in mind that I was like aggressively cutting the wearing this process and at that point I was about 15 pounds down in
- 1:43Three weeks
- 1:45And then I went on vacation. I went on vacation with my girlfriend's family in Florida and I
- 1:51kind of made a plan going forward
- 1:53Knowing that I was you know aggressively cutting for the last three weeks
- 1:57I wanted to be smart about my diet and then give myself the opportunity to eat what I wanted as long as I knew that
- 2:04I genuinely wanted it and I just wanted to have an overall good relationship with food
- 2:07Make sure I was moving so on and so forth. However, you know that trip
- 2:13Exceeded my expectations by far
- 2:17We ended up like unintentionally almost walking so much
- 2:21Disney Springs down there we walked a crap ton and it wasn't like we're walking so that we can eat type of thing at all
- 2:27It was just like we were having so much fun because you know, we're active people my girlfriend and I
- 2:32Just like walking around and you know
- 2:35Taking all these steps and burning all these extra calories
- 2:38And then kind of like shopping and exploring and experiencing during the whole process
- 2:42We also went to the gym every day that we were there that wasn't a travel day and needless to say I
- 2:48Had and it kind of rolled over to now
- 2:52The best relationship that I've ever had with food like in the morning
- 2:56I took priority and getting you know what I needed in my body for the sake of like digestion
- 3:02And just what I believe that I should be eating every day
- 3:05and then
- 3:07Obviously at night same thing with my digestive routine kind of making sure that
- 3:11Everything that needed to be in place was in place and then from there if there was something that I wanted food wise
- 3:18I
- 3:19Outside of my diet per se even though that's not really a thing for me right now
- 3:25Is what I'm kind of trying to explain I would eat it
- 3:28But like only if I knew that I really wanted it like there was a day where I was like
- 3:32I really want to do not and then we saw food of do not and
- 3:35The day went by I didn't I'm being able to get though not that the next day
- 3:38I was like don't want to do not and I really didn't want it
- 3:41After initially thinking that you know, I want to go get it the next like the next day came by
- 3:46I still didn't want to do not I
- 3:49Was about to leave I went to the bathroom from where I came back. I was like
- 3:53I want to don't I still didn't want it. I didn't get it. It sounds kind of weird
- 3:56But I like this is just generally how it went and then on the fourth day
- 3:59I was like I want to don't I got the donut I loved it on it
- 4:01And you know this kind of happened with like multiple foods throughout the process
- 4:05I'll be like a nice dinner where definitely like the most food I've eaten while
- 4:10even before I was like aggressively dieting and
- 4:13All of this to say all this fun food and you know proper precaution
- 4:18You know hitting all the boxes when I was there checking other boxes. I managed to lose weight while on that vacation
- 4:24I managed to lose a pound and a half between staying in the gym and the steps
- 4:31While we're you know exploring and eventually the venturing and then also in the morning and then the Florida heat
- 4:37Just being way more active
- 4:39And then you know checking off those boxes food and diet that just allows whatever you want to call it
- 4:44I managed to lose a pound and a half in a week
- 4:46On a vacation eating you know freely if you will after dieting so extremely hard for you know three and a half weeks at that point
- 4:54Three weeks whatever and now fast forward to about a month and a half. I can honestly say like
- 5:01Something's working right like something's working. I'm taking more steps than you know
- 5:05I was before I started this test of fencing thing, but by no means am I hitting 20,000 set days like I was in Florida
- 5:11Honestly, there's been days in the last week and a half since I've been back from Florida where I haven't had 10,000
- 5:17Just because you know life is busy
- 5:20And all that to say that my weight has to drop and I kind of
- 5:26You kind of get to know your body and you you start to
- 5:29You just really learn it. I'm at the point now where I know exactly what to
- 5:34What I can eat to kind of stay right around the same weight and that's what I'm doing
- 5:37I will kind of drop a few ounces occasionally, so technically still losing weight
- 5:42But I've lost about 20 pounds since you know I started like aggressively cutting about
- 5:48a month and a half ago now
- 5:50And I've kind of just like allowed my body to stay at that point while I kind of caught up if you will and and
- 5:56I wonder remind my body that it was you know in a deficit in the first place even though like I said
- 6:01It hasn't been struggling. It's been thriving at this point. You know I have sorry
- 6:06I had to turn my air on it was hot as hell at this point
- 6:09My diet is mainly locked in you know the whole foods the digestive
- 6:15Best friends and foods if you will but I've had like a sweet treat
- 6:20Every day as my girlfriend would call it and like I said weight is you know kind of right where it needs to be staying still
- 6:27And then also kind of dropping a few ounces occasionally as well
- 6:30So technically still losing in a sense and on days that I do do like a little bit of extra cardio hop in the treadmill
- 6:38At homes like I have I have one in my living room now or sorry my living in my room. I've one of my room
- 6:44It the way sheds like the next morning. I'm down like a pound and a half. It's kind of nuts. So I
- 6:50Don't know. I don't know. I don't know if this was the test of fencing if this was
- 6:54You know getting my diet and my digestive
- 6:56Order thing and track on top of the test of fencing. I don't know
- 7:02There's really no way for me to know too much. But bottom line is I have had a lot of success with test of fencing
- 7:10Dry mouth is still a thing but not nearly as bad as it was
- 7:15Heart rate doesn't really spike
- 7:18to the point where I'm like
- 7:20Concerned or take no anymore. I would say very very very rarely
- 7:24And you know what it's good. It's really good. It's good
- 7:29Like the only bad thing I could say is like it's pricey
- 7:32But for what it does for everything I just talked about in the last seven and a half minutes is it pricey?
- 7:36Where is it worth it?
- 7:38Also like this was not supposed to be seven and a half minutes of yapping but I know some people wanted an update
- 7:44not doing social media anymore
- 7:47for much of a reason other than to
- 7:49Have fun and yap with it because if I want to be creative and and
- 7:57Sappy and professional then I'll just do that
- 8:00With all of my clients because that's what I do for a living. So here. I'll just yeah like I just did
- 8:05I know you all want an update. I gave it to you
- 8:07Overall test of fencing gosh very high out of 10 very high out of 10
- 8:13Obviously due to diligence make sure your diets in order. That's probably the biggest thing
- 8:17No, just hop on this while eating like shit has some sort of deficit that you can
- 8:22maintain
- 8:23Before you take anything before taking the test of fencing and then other than that
- 8:28I like it. I like it a lot talk soon
Tesofensine for weight loss: what the hype gets wrong
Quick answer
The creator is using tesofensine, a triple monoamine reuptake inhibitor in late-stage research, alongside aggressive caloric restriction and high daily activity. He reported early cardiovascular and mood side effects consistent with the drug's noradrenergic and serotonergic activity, which resolved without medical intervention. Neither tesofensine's long-term safety profile nor its regulatory approval status supports unsupervised use, and the mood and heart rate effects he described are documented pharmacological signals, not incidental noise.
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This page currently connects to 7 source-backed evidence items through visible references or structured citation data.
PubMed evidence trail
Research sources used to frame this page
For Tesofensine for weight loss: what the hype gets wrong, FormBlends checks the page topic against primary trials, systematic reviews, guidelines, and current PubMed-indexed literature where available. These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient.
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Primary STEP 1 trial source for semaglutide weight-management efficacy and adverse-event context.
PubMed
Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance
Used for maintenance, discontinuation, and weight-regain discussions after semaglutide response.
PubMed
Efficacy of GLP-1 Receptor Agonists on Weight Loss, BMI, and Waist Circumference
A broad meta-analysis anchor for GLP-1 weight-loss effect and class-level comparisons.
PubMed
Discontinuing glucagon-like peptide-1 receptor agonists and body habitus
Used for pages discussing stopping therapy, weight regain, and long-term planning.
PubMed
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Tesofensine for weight loss: what the hype gets wrong should be treated as a claim to verify, then compared with evidence, safety context, and a provider review path.
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What this exact clip is really saying
This FormBlends review is specific to "Tesofensine for weight loss: what the hype gets wrong" from Joe Vito 💪📝📸🤳. We read the clip as a GLP-1 social video fact-checks claim about GLP-1 social video fact-checks, then separate the useful signal from what a short social video cannot prove. The page-specific claim focus is: The creator is using tesofensine, a triple monoamine reuptake inhibitor in late-stage research, alongside aggressive caloric restriction and high daily activity.
The reason this review is not generic is the source wording and the canonical claim label "glp1 replying to cory robert took a while for an update but you g." In this clip, the useful excerpt is: "Alright, this is gonna be my test-affencing update." That wording changes the review because it points to GLP-1 social video fact-checks evidence, safety, and patient-fit context, not a one-size-fits-all protocol.
The source trail for this page is checked against Once-Weekly Semaglutide in Adults with Overweight or Obesity (2021), Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance (2021), and Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight (2022), plus the creator's own wording. GLP-1 social video fact-checks decisions still need an eligibility review, medication-interaction screen, access check, and quality-control review before anyone treats a social clip as medical advice.
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Claim being checked
The creator is using tesofensine, a triple monoamine reuptake inhibitor in late-stage research, alongside aggressive caloric restriction and high daily activity.
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Use the clip as a claim to verify, not a treatment plan
What it helps with
- The creator is using tesofensine, a triple monoamine reuptake inhibitor in late-stage research, alongside aggressive caloric restriction and high daily activity. He reported early cardiovascular and mood side effects consistent with the drug's noradrenergic and serotonergic activity, which resolved without medical intervention. Neither tesofensine's long-term safety profile nor its regulatory approval status supports unsupervised use, and the mood and heart rate effects he described are documented pharmacological signals, not incidental noise.
- Tesofensine is not FDA-approved and has not completed phase 3 trials in the US; long-term safety data does not exist for this compound the way it does for approved weight-loss medications.
- The Astrup et al. 2008 Lancet phase 2 trial documented average heart rate increases of up to 7.4 bpm at the 0.5 mg dose, making elevated heart rate a primary safety signal, not a minor side effect.
What it may miss
- It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
- Compound access, legal status, and product quality still need a separate safety check.
- Social video captions rarely show the full evidence base behind a claim.
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Start provider reviewWhat You'll Learn
- Tesofensine is not FDA-approved and has not completed phase 3 trials in the US; long-term safety data does not exist for this compound the way it does for approved weight-loss medications.
- The Astrup et al. 2008 Lancet phase 2 trial documented average heart rate increases of up to 7.4 bpm at the 0.5 mg dose, making elevated heart rate a primary safety signal, not a minor side effect.
- Mood changes on a drug that blocks dopamine, serotonin, and norepinephrine reuptake simultaneously are pharmacological effects, not coincidences, and should be disclosed to a prescriber rather than self-managed.
- Losing 15 pounds in three weeks on aggressive caloric restriction typically includes 5-8 pounds of water and glycogen weight in the first week alone; net fat loss over that period is meaningfully lower than the scale number.
- Tesofensine works through a completely different mechanism than GLP-1 receptor agonists like semaglutide; grouping them together in conversation obscures important differences in cardiovascular risk profile and regulatory status.
- Appetite normalization and reduced hedonic eating are real, documented effects of monoamine-based appetite suppressants, and the creator's description of waiting to genuinely want food before eating it is consistent with research on food-reward suppression.
- Anyone using tesofensine should have baseline and ongoing cardiovascular monitoring, including resting heart rate and blood pressure, given the documented adrenergic activity of the compound.
Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team · This is not a transcript. It is our independent review of the video above.
What did @joe_vito_ actually say?
Over about six weeks on tesofensine, the creator reported losing roughly 15 pounds in three weeks of aggressive dieting, then an additional 1.5 pounds during a vacation where he ate freely. He described early side effects including dry mouth, elevated heart rate, and "a really dark couple of days" of low mood, which he said resolved on their own. He also described a dramatically reduced appetite, saying he could think he wanted a donut, walk away, and genuinely not want it the next day.
To be clear: he is not claiming tesofensine cured anything or prescribing a dose. He is sharing a personal experience. That matters for how we evaluate this, but personal experience is not clinical evidence, and some of what he described deserves a closer look.
Does the science back this up?
Tesofensine's appetite suppression effects are real and documented, but the cardiovascular and mood side effects he described are also well-documented in trials and not something to wave off as personal quirks.
Tesofensine is a triple monoamine reuptake inhibitor, blocking reuptake of dopamine, serotonin, and norepinephrine. The landmark phase 2 trial (Astrup et al., 2008, The Lancet) showed subjects in the 0.5 mg group lost about 12.8 kg over 24 weeks compared to 2.2 kg on placebo. That is significant weight loss, and appetite suppression was the primary driver. So losing 15 pounds in three weeks of aggressive calorie restriction while on tesofensine is biologically plausible, though some of that is water weight and glycogen depletion, not purely fat.
The mood effects he described, including those "dark couple of days," are harder to dismiss. Given that tesofensine affects serotonin and dopamine pathways, psychiatric effects are a genuine concern. The same Lancet trial flagged increases in heart rate and blood pressure as the primary safety signals. Elevated heart rate is not a benign quirk. It was one of the main reasons tesofensine's development was slowed.
What did they get wrong (or right)?
He got the appetite suppression experience right in the sense that it tracks with what trials show. The mechanism is real. Where he stumbles is in framing the mood and heart rate side effects as things that just went away and therefore were not a big deal. That reasoning is not sound.
Saying "I knew that it was likely that I was just feeling" off because he was feeling off is circular logic. Mood disruption and elevated heart rate on a drug that directly manipulates dopamine, serotonin, and norepinephrine are pharmacological effects, not coincidences. Dismissing them because they resolved is like saying a fever was not drug-related because it broke. The Astrup 2008 trial documented heart rate increases of up to 7.4 beats per minute in the 0.5 mg group. That is not trivial.
He also deserves credit for something: the way he described his vacation eating, waiting to genuinely want food before eating it, actually reflects what appetite normalization is supposed to look like. That is not a crazy observation. It aligns with how reduced hedonic eating has been described in GLP-1 and monoamine-based appetite suppression research.
What should you actually know?
Tesofensine is not FDA-approved. It is not a GLP-1 receptor agonist, though it is often discussed in the same weight-loss drug conversations. It works through a completely different mechanism. As of publication, it has not completed phase 3 trials in the United States, meaning long-term safety data does not exist in the way it does for approved medications.
The side effects the creator described, including dry mouth, elevated heart rate, and mood changes, are consistent with what clinical trials have documented. These are not rare or unexpected. Anyone using this compound should be doing so under medical supervision with regular monitoring of cardiovascular metrics.
- Tesofensine is a research-stage compound, not an approved drug in most jurisdictions.
- Heart rate and blood pressure elevation are the primary documented safety concerns, not secondary ones.
- Mood changes on a drug affecting dopamine and serotonin pathways should be reported to a prescriber, not waited out alone.
- Rapid early weight loss of 15 pounds in three weeks on a severe calorie deficit includes a significant water and glycogen component, not purely fat.
Interested in GLP-1 or peptide therapy?
Get matched with licensed-provider review to help decide if it is right for you.
About the Creator
Joe Vito 💪📝📸🤳 · TikTok creator
6.1K views on this video
Replying to @Cory Robert Took a while for an update, but you got an 8 minute yap sesh to make up for it. 💯 - #weightloss #fatloss #tesofensine #gymrat #gymtok
Frequently asked questions
Quick answers based on this video and our medical team review.
What does the video say about tesofensine?
Tesofensine is not FDA-approved and has not completed phase 3 trials in the US; long-term safety data does not exist for this compound the way it does for approved weight-loss medications.
What does the video say about the astrup et al. 2008 lancet phase 2 trial documented?
The Astrup et al. 2008 Lancet phase 2 trial documented average heart rate increases of up to 7.4 bpm at the 0.5 mg dose, making elevated heart rate a primary safety signal, not a minor side effect.
What does the video say about mood changes on a drug?
Mood changes on a drug that blocks dopamine, serotonin, and norepinephrine reuptake simultaneously are pharmacological effects, not coincidences, and should be disclosed to a prescriber rather than self-managed.
What does the video say about losing 15 pounds in three weeks on aggressive caloric restriction?
Losing 15 pounds in three weeks on aggressive caloric restriction typically includes 5-8 pounds of water and glycogen weight in the first week alone; net fat loss over that period is meaningfully lower than the scale number.
What does the video say about tesofensine works through a completely different mechanism than glp-1 receptor?
Tesofensine works through a completely different mechanism than GLP-1 receptor agonists like semaglutide; grouping them together in conversation obscures important differences in cardiovascular risk profile and regulatory status.
What does the video say about appetite normalization?
Appetite normalization and reduced hedonic eating are real, documented effects of monoamine-based appetite suppressants, and the creator's description of waiting to genuinely want food before eating it is consistent with research on food-reward suppression.
Sources & references
Citations extracted from our medical team's review. Click any citation to search PubMed.
Read More on This Topic
Our written guides go deeper with dosing details, comparison tables, and medical-team reviewed protocols.
Not medical advice. This video was made by Joe Vito 💪📝📸🤳, not by FormBlends. Our write-up above is an editorial review, not a medical recommendation. Talk to your doctor before making any decisions about medications or treatments.