Wegovy for PCOS weight loss: what month 3 really looks like

What did @alexusdevon actually say?

She's starting her third month on Wegovy and addressing viewer feedback about injection sites. Her position: she prefers her stomach over her arms or thighs, but she does rotate locations within the abdomen, alternating sides each week. She also mentioned feeling the needle this time, describing it as "a little pinch" that doesn't hurt but is noticeable. That's the full scope of the injection-related claims here.

This is a practical, experience-based video, not a medical tutorial. She's sharing what works for her body and her comfort level, which is a reasonable thing to do. The question is whether what she's describing is actually safe and in line with clinical guidance, or whether her 216,000 viewers should be doing something different.

Does the science back this up?

Mostly, yes. Rotating injection sites within a single region like the abdomen is clinically acceptable, and semaglutide's prescribing information (Novo Nordisk, 2023) explicitly lists the abdomen as one of the approved injection sites alongside the thigh and upper arm. She's not wrong to use her stomach.

The rotation-within-a-region approach she describes, alternating left and right sides weekly, aligns with standard nursing guidance on subcutaneous injections. A 2014 review by Hirsch et al. in the journal Diabetes Technology and Therapeutics found that site rotation within a region reduces the risk of lipohypertrophy, a lump-forming condition caused by repeated trauma to the same tissue. Lipohypertrophy can impair drug absorption, so rotation isn't just comfort advice, it's pharmacokinetically relevant. She's doing the right thing here, even if she doesn't frame it in those terms.

What did they get wrong (or right)?

Honestly, she got the fundamentals right. Rotating within the abdomen is acceptable. Avoiding the exact same spot each week is good practice. The "little pinch" sensation she describes is normal and not a sign of improper technique.

One thing worth flagging: she doesn't mention the two-inch rule, meaning injections should be placed at least two inches from the navel to avoid less effective absorption in that area. Novo Nordisk's guidance and general subcutaneous injection protocols both specify this. It's a small but real gap in what she's sharing.

Also, sticking exclusively to the abdomen for the long term isn't ideal. Research on insulin injections, which use the same subcutaneous tissue as semaglutide, shows that using only one body region over months increases lipohypertrophy risk even with within-region rotation (Gentile et al., 2016, Journal of Diabetes Science and Technology). She says she may change in the future, which is the right instinct.

What should you actually know?

Subcutaneous injection technique matters more than most people think, and TikTok is not a reliable place to learn it. Here's what the clinical evidence actually supports:

• All three approved sites for semaglutide, abdomen, thigh, upper arm, are pharmacokinetically equivalent per Novo Nordisk's label. You can use your stomach, but you're not getting a special benefit from it over other sites.
• Rotate at least one inch from your previous injection within a region. Alternating sides of the abdomen weekly, as she does, is a reasonable way to do this.
• Stay at least two inches away from your navel. Periumbilical tissue has variable absorption characteristics.
• If you notice a firm lump, indentation, or thickened skin at an injection site, that's lipohypertrophy. Stop injecting into that spot and tell your prescriber.
• Feeling the needle is normal. Semaglutide auto-injectors use a small-gauge needle. A brief pinch sensation doesn't indicate a problem with technique.

If you're new to self-injection, your pharmacist or prescribing clinician should walk you through technique before you take injection tips from a social media video, including this one.

Bottom line: how worried should you be?

Not very, in this case. @alexusdevon isn't spreading dangerous misinformation. She's describing a reasonable, mostly correct approach to a real practical question about Wegovy use. The gaps in her guidance, no mention of the navel clearance rule, and the long-term case for rotating between body regions, are worth knowing. But this video isn't going to hurt anyone. It's a candid personal update, not a clinical protocol, and viewers should treat it accordingly.