HCG, kisspeptin, and enclomiphene: sorting hype from hormonal reality

What did @moreroidsmorefoidz actually say?

The creator claims a stack of HCG, enclomiphene (which he calls "chlomethine"), and kisspeptin is "the best half naddy test boosting stack." He says his testosterone went from 800 ng/dL to over 1,600 ng/dL over two months. He also says none of these compounds affect natural production, no post-cycle therapy is needed, and they are a viable alternative to TRT for men who want to stay "half naddy" (partially natural).

He also acknowledged that HCG gave him "high estrogenic effects," which is one of the few things he said that holds up to scrutiny. The rest of the video is a mixed bag of partly correct mechanisms, some genuine misconceptions, and a few claims that are either unverifiable or just wrong.

Does the science back this up?

Partially. Each compound does have real mechanisms for raising testosterone, but calling this stack consequence-free is where the video falls apart.

HCG (human chorionic gonadotropin) mimics luteinizing hormone (LH) and directly stimulates Leydig cells to produce testosterone. That part is well-documented. But long-term HCG use can desensitize LH receptors, which is the opposite of what he implies. A study by Liu et al. (2002, Journal of Clinical Endocrinology and Metabolism) confirmed HCG raises testosterone but also suppresses pituitary LH output through negative feedback, meaning it does affect your natural hormonal axis.

Enclomiphene is a selective estrogen receptor modulator (SERM) that blocks estrogen feedback at the hypothalamus, raising GnRH, LH, and FSH. Kim et al. (2016, BJU International) showed enclomiphene raised testosterone while preserving sperm production better than TRT. That is a real advantage. Kisspeptin is a neuropeptide that stimulates GnRH release. Small clinical trials, including work by Jayasena et al. (2014, Clinical Endocrinology), show it can acutely raise LH and testosterone, but sustained daily use is complicated by rapid receptor desensitization.

What did they get wrong (or right)?

He got the basic mechanism right: all three compounds work upstream of testosterone production. Credit where it is due. The problem is in what he glossed over.

Saying these compounds "don't affect your natural production" is simply incorrect. HCG suppresses pituitary LH because your body senses high testosterone and dials back. That is textbook negative feedback. Enclomiphene works by blocking estrogen signals at the hypothalamus, which means it is actively interfering with a normal regulatory loop. Calling that "not affecting natural production" is misleading by any reasonable interpretation.

His claim that "you don't need post-cycle therapy" is also shaky. While enclomiphene is sometimes used as post-cycle therapy itself, suddenly stopping HCG after extended use can cause a temporary LH and testosterone drop, which he actually hints at when he mentions "a little bit of a rebound." That rebound is the thing he says is not a problem, while simultaneously admitting it exists.

• HCG does raise testosterone but also raises estradiol, which he acknowledged.
• Enclomiphene has clinical backing as a testosterone-raising agent with fewer fertility side effects than TRT.
• Kisspeptin's effectiveness in a daily oral or injection protocol for long-term use is not well established.
• His personal anecdote of 800 to 1,600 ng/dL is unverifiable and does not constitute evidence.

What should you actually know?

If you are a man with clinically low testosterone and want to preserve fertility, enclomiphene specifically has a reasonable evidence base and is being used by some licensed clinicians. That is a legitimate conversation to have with a doctor. The rest of this stack is more complicated.

Kisspeptin therapy is still largely experimental outside of reproductive medicine research contexts. Pulsatile dosing matters enormously for this compound, and continuous exposure causes rapid receptor downregulation (Seminara et al., 2003, New England Journal of Medicine). The idea that you can just "take" kisspeptin daily and get sustained testosterone elevation oversimplifies the biology significantly.

HCG has real clinical uses, including in men on TRT who want to maintain testicular function. But it is a prescription medication in the United States, and sourcing it outside of a licensed provider carries regulatory and purity risks. The estrogenic side effects he mentioned, including potential gynecomastia and mood changes, are not minor afterthoughts.

No one should build a hormone stack based on a TikTok video. These are compounds that interact with your hypothalamic-pituitary-gonadal axis. Get bloodwork. Talk to a licensed provider who can actually review your labs.