What did @heidisomers actually say?
On her fifth IVF cycle, Heidi is using transdermal testosterone gel applied to her arms each evening, a protocol her clinic described as "testosterone priming." She's doing a 21-day course before her next retrieval cycle. She acknowledged potential side effects, including weight changes and voice deepening, but reasonably noted that the gel delivers far less testosterone than injected protocols used by men on TRT. She's being transparent about the process, which is refreshing.
What she described is a real, evidence-supported protocol used in some reproductive medicine clinics to improve ovarian response before IVF, particularly in women who have responded poorly to standard stimulation. This is not fringe medicine. It is not something she invented. Her clinic prescribed it, and there is actual published data behind it.
Does the science back this up?
Yes, more than most people realize. Testosterone priming before ovarian stimulation has a legitimate evidence base, though researchers are still working out who benefits most and what the optimal protocol looks like.
The rationale is biological: androgen receptors are present in granulosa cells and early follicles. Testosterone appears to upregulate FSH receptors and promote follicle growth in the preantral and antral stages. A 2019 meta-analysis by Noventa et al. in Reproductive BioMedicine Online found that transdermal testosterone supplementation was associated with significantly higher clinical pregnancy rates and live birth rates in poor ovarian responders undergoing IVF. A separate randomized controlled trial by Balasch et al., published in Human Reproduction, also supported improved follicle yield in low-responder patients. The effect is not massive, but for women who have already failed multiple cycles, modest gains matter. Heidi is on her fifth cycle, which puts her squarely in the population where this protocol has shown the most promise.
What did they get wrong (or right)?
Heidi got the pharmacology broadly right. Her description of the gel as delivering a much lower testosterone load than injectable TRT used by men is accurate. Transdermal testosterone absorbs at roughly 10 percent efficiency, and the doses used in IVF priming protocols, typically 5-10mg daily, are designed to achieve low physiologic levels, not the supraphysiologic ranges associated with masculinizing effects.
That said, her framing of side effects as unlikely could be slightly understated. Voice changes are genuinely rare at these doses and duration, but mild androgenic effects like acne, increased libido, or mood shifts are not uncommon even at low doses in some women. These are reversible. The more important thing she did not mention is absorption transfer risk. Transdermal gels can transfer to partners or children through skin contact, and that is something anyone using these products should know. Her clinic likely told her, but it did not make the video.
What should you actually know?
If you are a poor ovarian responder considering IVF, testosterone priming is worth a direct conversation with your reproductive endocrinologist. It is not a guaranteed fix, and the evidence is stronger for some subgroups than others. The Poseidon classification, a stratification system for poor prognosis IVF patients developed by a group of European reproductive specialists and published in Frontiers in Endocrinology in 2016, helps clinicians identify who is most likely to respond.
A few practical points worth knowing:
- Priming duration in published studies ranges from 5 to 21 days before stimulation starts. The 21-day protocol Heidi mentioned is on the longer end but within the studied range.
- Testosterone priming is distinct from DHEA supplementation, which is another androgen strategy some clinics use. They are not interchangeable.
- Side effects at these doses are typically mild and reversible after stopping the gel.
- Transfer precautions matter. Wash hands after application and allow the gel to dry before skin-to-skin contact.
- This is a prescription protocol requiring clinical oversight. Do not self-administer testosterone based on content you see online.
Heidi is doing this under clinical supervision, which is exactly how it should be done. Her transparency about being on her fifth cycle, and still showing up, is worth acknowledging.