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TRT and growth hormone myths: what the evidence actually says

Dr. Terry Simpson, MD, FACS

TikTok creator

49.9K viewsWatch on TikTok→

Quick answer

Testosterone replacement therapy is an FDA-regulated treatment for diagnosed hypogonadism, defined by consistent low serum testosterone plus clinical symptoms, not a term that accurately describes supraphysiologic hormone use for performance or physique goals. No legally marketed over-the-counter supplement contains bioactive testosterone, and the FDA classifies testosterone as a Schedule III controlled substance. Patients with suspected hypogonadism should pursue formal diagnostic workup with a licensed clinician before considering any treatment pathway.

Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team· This is not a transcript. It is our independent review of the video above.

What did @drterrysimpson actually say?

Dr. Terry Simpson calls out someone, apparently Liver King or a close associate, for framing steroid use as simply "TRT and growth hormone." He argues this language is deliberately deceptive, and he goes further, accusing Carnivore MD of selling supplements falsely marketed as containing "bioactive testosterone." His bottom line: if you think you have low testosterone, see a board-certified endocrinologist and skip the supplements.

The video is short and punchy, and it reads like a frustration that built up over time. Simpson's core message is consumer protection, not a clinical lecture. He's essentially saying two things: the framing of steroid use as "TRT" can mislead the public, and supplement brands exploiting testosterone anxiety are running a scam. Both points deserve a real look.

Does the science back this up?

On the TRT-versus-steroids framing issue, Simpson is largely correct. Supraphysiologic testosterone use, meaning doses that push levels well above the normal male range of roughly 300 to 1,000 ng/dL, is pharmacologically different from replacement therapy used to treat clinical hypogonadism. Calling the former "TRT" is misleading by definition.

The American Urological Association and the Endocrine Society both define TRT as therapy aimed at restoring testosterone to normal physiologic levels in men diagnosed with hypogonadism, confirmed by at least two morning serum testosterone measurements (Bhasin et al., 2010, Journal of Clinical Endocrinology and Metabolism). Using the term to describe performance-enhancing dosing obscures that distinction.

On the supplement claim, no over-the-counter supplement legally sold in the United States can contain testosterone. The FDA classifies testosterone as a Schedule III controlled substance. Any product marketed as containing "bioactive testosterone" is either making a false claim or is an illegal product. Period. The Federal Trade Commission has repeatedly warned against testosterone supplement marketing that implies hormonal activity without evidence (FTC, 2014, Deceptive Advertising Guidance).

What did they get wrong (or right)?

Simpson gets the core consumer protection argument right. But the video has a few gaps worth noting.

First, the phrase "do you think he looks like he needs to take that" is doing a lot of work. Physical appearance is a genuinely poor diagnostic standard for hypogonadism. Plenty of muscular men have clinically low testosterone, and plenty of men who look average have supraphysiologic levels. Diagnosis requires bloodwork, not a visual assessment. Simpson is a physician and should know this better than to lean on aesthetics as evidence.

Second, while his advice to see a board-certified endocrinologist is sound, it skips over real access issues. Endocrinologist wait times in the United States average 30 to 60 days in many markets, and not every patient has insurance coverage for hormonal workups. The advice is correct but incomplete.

Third, growth hormone is mentioned only briefly. GH use carries its own clinical and legal context that deserves more than a passing reference, particularly because off-label GH prescribing is a growing and genuinely complex issue (Liu et al., 2007, Annals of Internal Medicine).

What should you actually know?

If you are worried about low testosterone, the path forward is straightforward: get a blood test. The Endocrine Society recommends testing serum total testosterone in the morning, on at least two separate occasions, before any diagnosis or treatment decision is made.

No supplement legally sold without a prescription contains active testosterone. Products that claim to "support" testosterone levels typically contain zinc, vitamin D, or herbal ingredients like ashwagandha. Some of these have modest evidence behind them. None are equivalent to, or a substitute for, actual testosterone therapy when therapy is clinically indicated.

If TRT is genuinely warranted, the conversation belongs with a qualified clinician, ideally someone who can also rule out secondary causes of low testosterone like pituitary dysfunction, sleep apnea, or medication interactions. Self-diagnosing based on influencer content and purchasing supplements in response is a money sink at best and a health risk at worst.

Simpson is right to push back on the semantic game of calling steroid use "TRT." Language shapes how people understand risk, and when that language is used to sell supplements or protect a public persona, consumers lose.

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Testosterone replacement therapy is an FDA-regulated treatment for diagnosed hypogonadism, defined by consistent low serum testosterone plus clinical symptoms, not a term that accurately describes supraphysiologic hormone use for performance or physique goals.

FormBlends verdict

Testosterone replacement therapy is an FDA-regulated treatment for diagnosed hypogonadism, defined by consistent low serum testosterone plus clinical symptoms, not a term that accurately describes supraphysiologic hormone use for performance or physique goals. No legally marketed over-the-counter supplement contains bioactive testosterone, and the FDA classifies testosterone as a Schedule III controlled substance. Patients with suspected hypogonadism should pursue formal diagnostic workup with a licensed clinician before considering any treatment pathway.

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Use the clip as a claim to verify, not a treatment plan

What it helps with

  • Testosterone replacement therapy is an FDA-regulated treatment for diagnosed hypogonadism, defined by consistent low serum testosterone plus clinical symptoms, not a term that accurately describes supraphysiologic hormone use for performance or physique goals. No legally marketed over-the-counter supplement contains bioactive testosterone, and the FDA classifies testosterone as a Schedule III controlled substance. Patients with suspected hypogonadism should pursue formal diagnostic workup with a licensed clinician before considering any treatment pathway.
  • The Endocrine Society defines TRT as therapy restoring testosterone to normal physiologic range in diagnosed hypogonadal men, not a synonym for any testosterone use (Bhasin et al., 2010, JCEM).
  • Testosterone is a Schedule III controlled substance; no legally sold OTC supplement can contain active testosterone under U.S. federal law.

What it may miss

  • It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
  • Compound access, legal status, and product quality still need a separate safety check.
  • Social video captions rarely show the full evidence base behind a claim.

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What You'll Learn

  • The Endocrine Society defines TRT as therapy restoring testosterone to normal physiologic range in diagnosed hypogonadal men, not a synonym for any testosterone use (Bhasin et al., 2010, JCEM).
  • Testosterone is a Schedule III controlled substance; no legally sold OTC supplement can contain active testosterone under U.S. federal law.
  • A 2021 review in the World Journal of Men's Health found that 90% of top-selling testosterone supplements lacked peer-reviewed clinical trial evidence for their specific formulations.
  • Hypogonadism diagnosis requires at least two fasting morning serum testosterone measurements below 300 ng/dL plus clinical symptoms, according to current AUA guidelines.
  • Growth hormone use outside of diagnosed GH deficiency or specific approved indications carries real risks including insulin resistance and joint pathology (Liu et al., 2007, Annals of Internal Medicine).
  • Visual appearance, including muscularity, is not a reliable clinical indicator of testosterone status in either direction.
  • If you suspect low testosterone, a primary care physician can order initial bloodwork before a specialist referral, which may reduce wait time and out-of-pocket costs.

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About the Creator

Dr. Terry Simpson, MD, FACS · TikTok creator

49.9K views on this video

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Sources & references

Citations extracted from our medical team's review. Click any citation to search PubMed.

Educational use only. This fact-check is editorial content for general information. Nothing here is medical advice. Talk to a licensed provider about your specific situation before starting, stopping, or changing any supplement, peptide, or medication regimen.

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Not medical advice. This video was made by Dr. Terry Simpson, MD, FACS, not by FormBlends. Our write-up above is an editorial review, not a medical recommendation. Talk to your doctor before making any decisions about medications or treatments.