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Originally posted by @drsteveng on Instagram · 73s|Watch on Instagram
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Auto-generated transcript of @drsteveng's video. Quoted here for educational fact-check commentary; original creator retains all rights to the video content.

  1. 0:00Here's the most overlooked strategy to optimize your testosterone, whether it be your own testosterone,
  2. 0:05or if you're taking testosterone replacement therapy.
  3. 0:08Addressing your blood sugar and carbohydrate tolerance.
  4. 0:11Allow me to explain.
  5. 0:12Factors that impact your blood sugar as well as your carbohydrate tolerance are also the
  6. 0:17same factors that can convert your testosterone into estrogen.
  7. 0:21That's the last thing you want.
  8. 0:22Here's a list of the most important blood tests that can give us a clue as to whether
  9. 0:25or not you are carbohydrate intolerant, have blood sugar issues, or are insulin resistant.
  10. 0:31Fasting glucose, hemoglobin A1c, triglycerides, liver enzymes, AST and ALT, and fasting insulin.
  11. 0:38Your fasting insulin should be under the number 6.
  12. 0:41Your AST and ALT liver enzymes should be under the number 25.
  13. 0:46Your triglycerides should be under the number 100.
  14. 0:49Your fasting glucose should be between 85 and 92.
  15. 0:53And your hemoglobin A1c should be between 4.8 and 5.2.
  16. 0:57Addressing these markers will go a long way in helping you optimize your own testosterone
  17. 1:02production as well as benefit from testosterone you may be taking from your doctor.
  18. 1:07If you liked the content of this video and would like to see more, please like, follow, and
  19. 1:10share this with someone you know.

Does low testosterone really start with insulin resistance?

Steven Geanopulos

Instagram creator

119.8K viewsView on Instagram

Quick answer

Insulin resistance and obesity suppress the hypothalamic-pituitary-gonadal axis and increase peripheral aromatase activity in adipose tissue, both of which can lower serum testosterone in men. The creator's recommendation to assess fasting glucose, HbA1c, fasting insulin, triglycerides, and liver enzymes as metabolic proxies is clinically reasonable, though the specific cutoff values he cites reflect functional medicine conventions rather than consensus clinical guidelines. Men with suspected low testosterone should be evaluated by a licensed clinician to distinguish between secondary hypogonadism driven by metabolic dysfunction and other causes that metabolic intervention alone will not address.

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What this exact clip is really saying

This FormBlends review is specific to "Does low testosterone really start with insulin resistance?" from Steven Geanopulos. We read the clip as a TRT social video fact-checks claim about Testosterone, then separate the useful signal from what a short social video cannot prove. The page-specific claim focus is: Insulin resistance and obesity suppress the hypothalamic-pituitary-gonadal axis and increase peripheral aromatase activity in adipose tissue, both of which can lower serum testosterone in men.

The reason this review is not generic is the source wording and the canonical claim label "trt optimize your testosterone by getting your blood sugar in or." In this clip, the useful excerpt is: "Here's the most overlooked strategy to optimize your testosterone, whether it be your own testosterone, or if you're taking testosterone replacement therapy." That wording changes the review because it points to Testosterone evidence, safety, and patient-fit context, not a one-size-fits-all protocol.

The source trail for this page is checked against Cardiovascular Safety of Testosterone-Replacement Therapy (2023), Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline (2010), and Functional testosterone deficiency in aging men: Clinical impact, diagnostic pathways, and treatment strategies (2026), plus the creator's own wording. Testosterone decisions still need an eligibility review, medication-interaction screen, access check, and quality-control review before anyone treats a social clip as medical advice.

Aromatase activity in adipose tissue, not insulin directly, is the primary driver of testosterone-to-estrogen conversion in men with metabolic dysfunction.
People who land here are usually comparing the Testosterone claim with bloodtest, lowt, and insulinresistance.
The strongest next step is to compare the claim with FormBlends' Testosterone guide, evidence notes, and provider review path before acting.

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Claim being checked

Insulin resistance and obesity suppress the hypothalamic-pituitary-gonadal axis and increase peripheral aromatase activity in adipose tissue, both of which can lower serum testosterone in men.

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Testosterone evidence, safety, and patient-fit context

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What to do with this video

Use the clip as a claim to verify, not a treatment plan

What it helps with

  • Insulin resistance and obesity suppress the hypothalamic-pituitary-gonadal axis and increase peripheral aromatase activity in adipose tissue, both of which can lower serum testosterone in men. The creator's recommendation to assess fasting glucose, HbA1c, fasting insulin, triglycerides, and liver enzymes as metabolic proxies is clinically reasonable, though the specific cutoff values he cites reflect functional medicine conventions rather than consensus clinical guidelines. Men with suspected low testosterone should be evaluated by a licensed clinician to distinguish between secondary hypogonadism driven by metabolic dysfunction and other causes that metabolic intervention alone will not address.
  • A 2014 review by Grossmann in JCEM confirmed a bidirectional relationship between metabolic syndrome and hypogonadism in men, supporting the general premise of the video.
  • Aromatase activity in adipose tissue, not insulin directly, is the primary driver of testosterone-to-estrogen conversion in men with metabolic dysfunction.

What it may miss

  • It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
  • Compound access, legal status, and product quality still need a separate safety check.
  • Social video captions rarely show the full evidence base behind a claim.

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What You'll Learn

  • A 2014 review by Grossmann in JCEM confirmed a bidirectional relationship between metabolic syndrome and hypogonadism in men, supporting the general premise of the video.
  • Aromatase activity in adipose tissue, not insulin directly, is the primary driver of testosterone-to-estrogen conversion in men with metabolic dysfunction.
  • A 2016 meta-analysis by Corona et al. in the European Journal of Endocrinology found lifestyle intervention and weight loss raised testosterone in overweight hypogonadal men, sometimes significantly.
  • Fasting insulin assays differ between laboratories, and a single target like 'under 6 uIU/mL' can produce different clinical interpretations depending on the lab used.
  • The relationship between testosterone and insulin sensitivity is bidirectional. TRT itself has been shown to improve insulin sensitivity in hypogonadal men (Kapoor et al., 2006, European Journal of Endocrinology).
  • Low testosterone has multiple documented causes including primary hypogonadal failure, pituitary pathology, and sleep apnea, none of which will respond to blood sugar optimization.
  • The specific lab cutoffs in this video are functional medicine conventions. Standard clinical guidelines from the ADA and Endocrine Society use different, and generally broader, reference ranges.

Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team · This is not a transcript. It is our independent review of the video above.

What did @drsteveng actually say?

The creator, who lists chiropractic among his hashtags, argues that blood sugar control is "the most overlooked strategy" for testosterone optimization. His core claim: the same factors that drive insulin resistance also "convert your testosterone into estrogen." He then lists five lab markers and gives specific target ranges for each, including a fasting insulin under 6, AST and ALT under 25, triglycerides under 100, fasting glucose between 85 and 92, and hemoglobin A1c between 4.8 and 5.2. These are tighter than most standard clinical reference ranges, which is worth examining carefully.

The framing applies to both men trying to optimize natural testosterone and those already on testosterone replacement therapy. The implication is that metabolic dysfunction is a root cause of low T, not just a correlating factor. That distinction matters a lot clinically.

Does the science back this up?

Partially, and the core connection is real, but it is being simplified in ways that could mislead viewers. The link between insulin resistance and lower testosterone in men is well-established. A 2014 study by Grossmann in the Journal of Clinical Endocrinology and Metabolism confirmed a bidirectional relationship between hypogonadism and metabolic syndrome. Obesity and insulin resistance suppress gonadotropin-releasing hormone, which reduces LH signaling to the testes, which reduces testosterone output. That part checks out.

The aromatase angle, that excess insulin activity and adipose tissue convert testosterone to estrogen, is also supported by evidence. Corona et al. (2010, Journal of Sexual Medicine) found that elevated estradiol in obese hypogonadal men correlated with aromatase activity in fat tissue, not just insulin per se. So the mechanism is real, but insulin resistance and obesity are intertwined, and the video does not distinguish between them clearly. Insulin itself does not directly run the aromatase enzyme. Fat mass does. This is a meaningful nuance the video glosses over.

What did they get wrong (or right)?

The specific lab targets deserve scrutiny. Clinical laboratories use fasting glucose reference ranges of roughly 70 to 99 mg/dL. The creator's recommended range of 85 to 92 is a functional medicine preference, not a standard clinical cutoff. There is no large randomized trial showing that a fasting glucose of 84 is meaningfully worse for testosterone than one of 88. This precision sounds scientific but is not well-validated at that resolution.

The fasting insulin target of under 6 uIU/mL is similarly a functional medicine convention. The American Diabetes Association does not include fasting insulin in its standard diagnostic criteria, partly because insulin assays vary significantly between labs (Greenfield and Russell, 2011, Journal of Clinical Endocrinology and Metabolism). Telling 119,000 viewers their insulin must be under 6 without acknowledging assay variability is a real problem.

On the other hand, recommending triglycerides under 100 and using liver enzymes as metabolic proxies are reasonable clinical approaches. Elevated triglycerides and ALT do track with insulin resistance, and those connections are legitimate.

What should you actually know?

If you have clinically diagnosed low testosterone, metabolic health absolutely belongs in the conversation. A 2016 meta-analysis by Corona et al. in the European Journal of Endocrinology found that weight loss and lifestyle intervention improved testosterone levels in overweight hypogonadal men, sometimes substantially. Treating insulin resistance is not a fringe idea. It is good medicine.

But the framing that blood sugar is the "most overlooked" driver of low T skips over other well-documented causes: primary hypogonadism, pituitary disorders, medication side effects, sleep apnea, and age-related decline. Insulin resistance is one pathway among several. Viewers watching this who have a genuinely broken hypothalamic-pituitary-gonadal axis will not fix their testosterone by optimizing their A1c.

Also worth flagging: the creator does not mention that the relationship between testosterone and insulin resistance is bidirectional. TRT itself can improve insulin sensitivity in hypogonadal men (Kapoor et al., 2006, European Journal of Endocrinology). The video presents it as one direction only, which is an incomplete picture.

  • Insulin resistance and low testosterone are genuinely linked, but the mechanism runs mostly through adipose tissue aromatase, not insulin directly.
  • The specific lab cutoffs listed are functional medicine conventions, not universally validated clinical thresholds.
  • Fasting insulin results vary by lab assay, making a single universal target like "under 6" less reliable than implied.
  • Improving metabolic health can raise testosterone in overweight men with secondary hypogonadism, but will not fix primary testicular failure.
  • The relationship is bidirectional: low testosterone also worsens insulin resistance, a fact the video omits entirely.

Bottom line

The broad point, that metabolic health matters for testosterone, is legitimate and underemphasized in mainstream care. But the specific numerical targets presented as precise medical standards are not universally validated, the mechanistic explanation oversimplifies the aromatase pathway, and the framing as the single "most overlooked" cause of low T overstates the case. Take the general message seriously. Take the specific numbers back to a board-certified endocrinologist or internist before acting on them.

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About the Creator

Steven Geanopulos · Instagram creator

119.8K views on this video

Optimize your testosterone by getting your blood sugar in order first. Low T. Starts with insulin resistance. #bloodtest #lowt #insulinresistance #doctorsofinstagram #metabolichealth #chiropractic

Frequently asked questions

Quick answers based on this video and our medical team review.

What does the video say about a 2014 review by grossmann in jcem confirmed a bidirectional?

A 2014 review by Grossmann in JCEM confirmed a bidirectional relationship between metabolic syndrome and hypogonadism in men, supporting the general premise of the video.

What does the video say about aromatase activity in adipose tissue, not insulin directly,?

Aromatase activity in adipose tissue, not insulin directly, is the primary driver of testosterone-to-estrogen conversion in men with metabolic dysfunction.

What does the video say about a 2016 meta-analysis by corona et al. in the european?

A 2016 meta-analysis by Corona et al. in the European Journal of Endocrinology found lifestyle intervention and weight loss raised testosterone in overweight hypogonadal men, sometimes significantly.

What does the video say about fasting insulin assays differ between laboratories,?

Fasting insulin assays differ between laboratories, and a single target like 'under 6 uIU/mL' can produce different clinical interpretations depending on the lab used.

What does the video say about the relationship between testosterone?

The relationship between testosterone and insulin sensitivity is bidirectional. TRT itself has been shown to improve insulin sensitivity in hypogonadal men (Kapoor et al., 2006, European Journal of Endocrinology).

What does the video say about low testosterone has multiple documented causes including primary hypogonadal failure,?

Low testosterone has multiple documented causes including primary hypogonadal failure, pituitary pathology, and sleep apnea, none of which will respond to blood sugar optimization.

Sources & references

Citations extracted from our medical team's review. Click any citation to search PubMed.

Educational use only. This fact-check is editorial content for general information. Nothing here is medical advice. Talk to a licensed provider about your specific situation before starting, stopping, or changing any supplement, peptide, or medication regimen.

Read More on This Topic

Our written guides go deeper with dosing details, comparison tables, and medical-team reviewed protocols.

Not medical advice. This video was made by Steven Geanopulos, not by FormBlends. Our write-up above is an editorial review, not a medical recommendation. Talk to your doctor before making any decisions about medications or treatments.