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Originally posted by @daviddemesquita on TikTok · 102s|Watch on TikTok
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Auto-generated transcript of @daviddemesquita's video. Quoted here for educational fact-check commentary; original creator retains all rights to the video content.

  1. 0:00TRT running HGG and tangent together. What are my thoughts?
  2. 0:04Running 200 I use of HGG per day and tangent with that TRT. So first and foremost if you guys don't know I
  3. 0:13Do work within the medical and the functional space as well as an Olympian coach now
  4. 0:18I personally believe that everyone that's on TRT should be on HGG of some sort at least for part of the year
  5. 0:25Me personally, I think it should be year round unless if certain circumstances are in place and then it can be dropped for a period of time
  6. 0:33More research is coming out that saying on HGG
  7. 0:36Has proven to show that you have about a 60% odds of returning with fertility after stopping
  8. 0:44exogenous
  9. 0:45Hormone use
  10. 0:46Now that is mainly genetic related. However, let's jump into the daily use of HGG though
  11. 0:51Now the issue that I have with daily use of HGG is simply do the fact that
  12. 0:57Our gems they reload
  13. 1:01We use them and then they reload again
  14. 1:04So it works in a cyclical system and the whole point to it is that we try to emulate what naturally is being done. So they fill
  15. 1:14It gets
  16. 1:16unloaded after two days and then it reloads
  17. 1:19Therefore to emulate that you do every other day and I personally do believe that is the best for out to go
  18. 1:26Now I have some urologists that follow me on this page and they would probably say the same exact thing that every other day use of HGG is
  19. 1:32Probably the better approach. So I'm sure a little comment down below
  20. 1:35But I'm curious to know what you guys have found to be most useful for you
  21. 1:39Me personally, I only do every other day

@daviddemesquita's TRT claims need context, we checked

David DeMesquita™️

TikTok creator

17.2K viewsWatch on TikTok →

Quick answer

HCG is used as an adjunct to exogenous testosterone therapy to preserve intratesticular testosterone production, testicular volume, and spermatogenesis by mimicking LH at the Leydig cell receptor. Dosing protocols in clinical practice typically range from 250 to 500 IU administered two to three times per week rather than daily, based on evidence that intermittent stimulation reduces LH receptor desensitization and manages estradiol elevation from aromatization. Fertility outcomes following cessation of TRT are variable and depend on duration of suppression, baseline reproductive function, and patient age, not a fixed genetic probability.

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Regulatory reality

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Safety screen

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This page currently connects to 6 source-backed evidence items through visible references or structured citation data.

PubMed evidence trail

Research sources used to frame this page

For @daviddemesquita's TRT claims need context, we checked, FormBlends checks the page topic against primary trials, systematic reviews, guidelines, and current PubMed-indexed literature where available. These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient.

Randomized trialTestosterone and TRT evidence2023

Cardiovascular Safety of Testosterone-Replacement Therapy

TRAVERSE trial anchor for cardiovascular-safety discussions in appropriately diagnosed men.

PubMed

GuidelineTestosterone and TRT evidence2010

Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline

Guideline anchor for diagnosis, monitoring, contraindications, and appropriate TRT framing.

PubMed

ReviewMenopause and hormone evidence2012

Understanding weight gain at menopause

Background source for body-composition and weight-change discussions around menopause.

PubMed

ReviewMenopause and hormone evidence2024

Management of obesity in menopause

Current source for menopause-specific obesity management framing.

PubMed

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@daviddemesquita's TRT claims need context, we checked is best used to compare access, oversight, pricing, pharmacy quality, and patient support before starting care.

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Testosterone and TRT video claims video hub

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View topic hubTestosterone and TRT video claimsExplore TRT accessTreatment or product pathRead low testosterone guideDeeper FormBlends guide

Page-specific review note

What this exact clip is really saying

This FormBlends review is specific to "@daviddemesquita's TRT claims need context, we checked" from David DeMesquita™️. We read the clip as a TRT social video fact-checks claim about Testosterone, then separate the useful signal from what a short social video cannot prove. The page-specific claim focus is: HCG is used as an adjunct to exogenous testosterone therapy to preserve intratesticular testosterone production, testicular volume, and spermatogenesis by mimicking LH at the Leydig cell receptor.

The reason this review is not generic is the source wording and the canonical claim label "trt replying to mr mayhem trt bodybuilding hrt." In this clip, the useful excerpt is: "TRT running HGG and tangent together." That wording changes the review because it points to Testosterone evidence, safety, and patient-fit context, not a one-size-fits-all protocol.

The source trail for this page is checked against Cardiovascular Safety of Testosterone-Replacement Therapy (2023), Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline (2010), and Functional testosterone deficiency in aging men: Clinical impact, diagnostic pathways, and treatment strategies (2026), plus the creator's own wording. Testosterone decisions still need an eligibility review, medication-interaction screen, access check, and quality-control review before anyone treats a social clip as medical advice.

The '60% fertility recovery' figure cited in the video has no clear source in peer-reviewed literature and should not be taken as a reliable probability.
People who land here are usually comparing the Testosterone claim with [object Object].
The strongest next step is to compare the claim with FormBlends' Testosterone guide, evidence notes, and provider review path before acting.

Claim verdict

The useful answer behind this video

This page is built to answer the specific claim behind the clip, then separate what is useful from what still needs clinical context. That makes the URL more than a repost: it gives Google, readers, and AI retrieval systems a concise verdict with source and safety boundaries.

Claim being checked

HCG is used as an adjunct to exogenous testosterone therapy to preserve intratesticular testosterone production, testicular volume, and spermatogenesis by mimicking LH at the Leydig cell receptor.

FormBlends verdict

Testosterone evidence, safety, and patient-fit context

Evidence strength

Source-backed review with clinical or regulatory citations.

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Compare the claim with FormBlends safety guidance and a licensed-provider review before acting.

What to do with this video

Use the clip as a claim to verify, not a treatment plan

What it helps with

  • HCG is used as an adjunct to exogenous testosterone therapy to preserve intratesticular testosterone production, testicular volume, and spermatogenesis by mimicking LH at the Leydig cell receptor. Dosing protocols in clinical practice typically range from 250 to 500 IU administered two to three times per week rather than daily, based on evidence that intermittent stimulation reduces LH receptor desensitization and manages estradiol elevation from aromatization. Fertility outcomes following cessation of TRT are variable and depend on duration of suppression, baseline reproductive function, and patient age, not a fixed genetic probability.
  • Coviello et al. (2005, JCEM) showed 250 IU HCG every other day is sufficient to maintain intratesticular testosterone in men on exogenous testosterone, supporting intermittent over daily dosing.
  • The '60% fertility recovery' figure cited in the video has no clear source in peer-reviewed literature and should not be taken as a reliable probability.

What it may miss

  • It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
  • Compound access, legal status, and product quality still need a separate safety check.
  • Social video captions rarely show the full evidence base behind a claim.

Best next step

Compare the claim against a FormBlends guide, safety page, and licensed-provider review before acting.

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What You'll Learn

  • Coviello et al. (2005, JCEM) showed 250 IU HCG every other day is sufficient to maintain intratesticular testosterone in men on exogenous testosterone, supporting intermittent over daily dosing.
  • The '60% fertility recovery' figure cited in the video has no clear source in peer-reviewed literature and should not be taken as a reliable probability.
  • HCG aromatizes to estradiol, which the video does not mention. Estrogen management is a real clinical consideration when adding HCG to a TRT protocol.
  • Post-TRT spermatogenic recovery can take 12 to 24 months or longer and is influenced by age, duration of suppression, and baseline fertility, not genetics alone.
  • Crosnoe et al. (2013, Fertility and Sterility) reviewed post-anabolic androgen recovery and found outcomes are highly variable, with no single recovery rate applicable across patient populations.
  • HCG is not approved by the FDA for use in TRT specifically; its application in this context is off-label, and any dosing decision requires a licensed prescriber reviewing individual labs.
  • Continuous high-dose HCG can cause LH receptor downregulation, which is the mechanistic basis for preferring lower, intermittent doses, a point the creator got directionally correct.

Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team · This is not a transcript. It is our independent review of the video above.

What did @daviddemesquita actually say?

The creator, who identifies as working in "the medical and the functional space" and as an Olympian coach, made several distinct claims about HCG use alongside TRT. He argued that everyone on TRT should use HCG "at least for part of the year," that HCG use gives roughly "a 60% odds of returning with fertility after stopping exogenous hormone use," and that daily HCG dosing is inferior to every-other-day dosing. His reasoning for the dosing preference was physiological: he described the testes as filling, unloading over two days, and reloading in a cyclical pattern, so every-other-day dosing better mimics natural LH pulsatility.

He also mentioned running 200 IU of HCG per day as the practice he was evaluating, and concluded that every-other-day is "the better approach" based on his own experience and conversations with urologists who follow him. Worth noting: the transcript consistently uses "HGG" which appears to be a transcription artifact for HCG (human chorionic gonadotropin).

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About the Creator

David DeMesquita™️ · TikTok creator

17.2K views on this video

Replying to @Mr mayhem #trt #bodybuilding #hrt

Frequently asked questions

Quick answers based on this video and our medical team review.

What does the video say about coviello et al. (2005, jcem) showed 250 iu hcg every?

Coviello et al. (2005, JCEM) showed 250 IU HCG every other day is sufficient to maintain intratesticular testosterone in men on exogenous testosterone, supporting intermittent over daily dosing.

What does the video say about the '60% fertility recovery' figure cited in the video has?

The '60% fertility recovery' figure cited in the video has no clear source in peer-reviewed literature and should not be taken as a reliable probability.

What does the video say about hcg aromatizes to estradiol,?

HCG aromatizes to estradiol, which the video does not mention. Estrogen management is a real clinical consideration when adding HCG to a TRT protocol.

What does the video say about post-trt spermatogenic recovery can take 12 to 24 months?

Post-TRT spermatogenic recovery can take 12 to 24 months or longer and is influenced by age, duration of suppression, and baseline fertility, not genetics alone.

What does the video say about crosnoe et al. (2013, fertility?

Crosnoe et al. (2013, Fertility and Sterility) reviewed post-anabolic androgen recovery and found outcomes are highly variable, with no single recovery rate applicable across patient populations.

What does the video say about hcg?

HCG is not approved by the FDA for use in TRT specifically; its application in this context is off-label, and any dosing decision requires a licensed prescriber reviewing individual labs.

Educational use only. This fact-check is editorial content for general information. Nothing here is medical advice. Talk to a licensed provider about your specific situation before starting, stopping, or changing any supplement, peptide, or medication regimen.

Read More on This Topic

Our written guides go deeper with dosing details, comparison tables, and medical-team reviewed protocols.

Not medical advice. This video was made by David DeMesquita™️, not by FormBlends. Our write-up above is an editorial review, not a medical recommendation. Talk to your doctor before making any decisions about medications or treatments.