What did @calxshreds actually say?
@calxshreds was responding to someone on TRT who started at 150mg and dropped to 120mg per week, still dealing with acne. Their core advice: twice-weekly injections cause hormone spikes that drive acne, so injecting three, four times weekly or even daily will "guarantee" improvement. They also pointed to DHT as the likely culprit over estrogen, suggested finasteride or dutasteride if DHT is the issue, floated adding primobolan or EQ at 50mg per week for estrogen-related acne, and rounded out with basic hygiene tips.
The injection frequency argument is the main claim worth examining. Everything else ranges from reasonable to genuinely problematic. That primobolan and EQ suggestion, in particular, deserves direct scrutiny because it is not appropriate advice to hand out on TikTok.
Does the science back this up?
The injection frequency logic has real pharmacological grounding, but the "guarantee" language oversells it significantly. Studies on testosterone cypionate and enanthate pharmacokinetics confirm that less frequent injections produce larger peak-to-trough swings. Shigehara et al. (2021, Androgens: Clinical Research and Therapeutics) noted that injection interval affects serum androgen stability, and that more frequent, smaller doses produce steadier hormone levels. Steadier levels logically reduce hormone-driven sebaceous gland stimulation.
On the DHT-acne connection, that part holds up. DHT activates androgen receptors in sebaceous glands more potently than testosterone, and sebum overproduction is a well-documented acne mechanism. Chen et al. (2002, Journal of Investigative Dermatology) showed androgen receptor expression in sebocytes responds directly to DHT. Finasteride reducing acne in androgen-sensitive patients has been documented, though primarily in female patients with hyperandrogenism. The evidence for using it specifically to manage TRT-related acne in men is thinner and mostly clinical observation rather than controlled trials.
What did they get wrong (or right)?
They got the core pharmacokinetics broadly right. More frequent, smaller injections do reduce peak androgen and estrogen fluctuations. That is not controversial. The framing of twice-weekly as "very suboptimal" is an opinion, though. Many endocrinologists and TRT clinicians use twice-weekly dosing as standard practice precisely because compliance improves without meaningful clinical downside for most patients.
The recommendation to add primobolan or EQ at 50mg per week to manage TRT acne is where this video goes off the rails. These are anabolic steroids. Suggesting someone already experiencing side effects from testosterone add more exogenous androgens to the stack is not harm reduction, it is the opposite. Neither compound has clinical evidence supporting its use as an acne management strategy, and both carry their own androgenic and cardiovascular risk profiles. This advice should not be followed.
The UV exposure tip is at least partially supported. Phototherapy has evidence in acne management (Elman and Lebzelter, 2004, Dermatologic Surgery), though casual sun exposure is not equivalent to controlled phototherapy and carries its own skin cancer risk tradeoff.
What should you actually know?
TRT-related acne is a real and common side effect, and it often does respond to injection frequency adjustments, but the response varies considerably between individuals. A systematic review by Borst and Mulligan (2007, Sports Medicine) noted that androgenic side effects from testosterone are highly individual and dose-dependent. Acne affecting someone on 120mg per week may have nothing to do with injection timing and everything to do with individual sensitivity, existing skin conditions, or concurrent diet and lifestyle factors.
If you are experiencing acne on TRT, the right move is a conversation with your prescribing clinician, not a TikTok comment section. A clinician can pull lab values for total testosterone, free testosterone, estradiol, DHT, and SHBG and actually identify which variable is driving the issue. Finasteride and dutasteride are legitimate clinical tools in specific cases, but they carry their own side effect profiles including sexual dysfunction and mood changes that warrant a proper informed consent discussion, not a "you could use something like" mention in a short-form video.
Bottom line
This video is a mixed bag. The injection frequency reasoning is pharmacologically coherent, even if overstated. The DHT focus is appropriate. The hygiene advice is harmless. But the suggestion to add anabolic steroids to manage a TRT side effect is genuinely bad advice, and the "guarantee" language applied to any hormonal intervention should raise immediate skepticism. Hormones are not that predictable.