Does PCOS actually cause high testosterone in women?
Quick answer
Elevated androgens in women require a structured differential diagnosis before attributing them to PCOS, which is the most common but not the only cause. Workup should include total and free testosterone, DHEA-S, SHBG, cortisol, and prolactin, with results interpreted in the context of cycle timing and validated assay methodology. Confirmed PCOS carries real cardiometabolic risk and warrants ongoing monitoring beyond symptom management.
Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team· This is not a transcript. It is our independent review of the video above.
What did @drjolenebrighten actually say?
Dr. Jolene Brighten told her 237K viewers that if a woman's testosterone is high, her doctor should be "ruling out polycystic ovarian syndrome or PCOS" because it's "the most common cause of elevated androgens in women." She listed symptoms including excess hair on the chin, chest, and abdomen, acne, irregular periods, and what she called cardiometabolic issues: weight trouble, insulin resistance, diabetes, and heart disease. Short video, fairly dense with clinical claims. The question is whether it holds up.
Does the science back this up?
Mostly, yes. PCOS is the most common cause of hyperandrogenism in women of reproductive age, and that is not a contested point. A 2018 review by Rosenfield and Ehrmann in the New England Journal of Medicine put PCOS prevalence at 6-12% of reproductive-age women, with hyperandrogenism present in the majority of diagnosed cases. The Endocrine Society's clinical guidelines also identify PCOS as the leading cause of elevated androgens in premenopausal women.
The cardiometabolic risks she names are real. Insulin resistance is present in roughly 65-70% of women with PCOS regardless of body weight, per Diamanti-Kandarakis and Dunaif (2012, Endocrine Reviews). The association with type 2 diabetes and cardiovascular risk markers is supported across multiple prospective studies. Hirsutism and acne as androgen-driven symptoms are not controversial. Irregular periods reflect anovulation, a core diagnostic criterion under both the Rotterdam and NIH frameworks.
What did they get wrong (or right)?
Two things deserve scrutiny. First, she does not mention that PCOS is a diagnosis of exclusion. Before landing on PCOS, clinicians are expected to rule out congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's syndrome, and hyperprolactinemia. The Endocrine Society is explicit about this. A video that implies elevated testosterone probably means PCOS could lead someone to skip workup for something more serious.
Second, she lists "trouble gaining weight" as a cardiometabolic symptom of PCOS. That phrasing is not well-supported. The dominant metabolic phenotype in PCOS involves weight gain and difficulty losing weight, not difficulty gaining it. This may have been a verbal slip, but it could genuinely confuse viewers. On the positive side, her advice to "check in" with a doctor rather than self-manage is exactly correct, and she doesn't overstate her role in the video.
What should you actually know?
If your testosterone is elevated on a lab panel, PCOS is a reasonable first suspicion. It is not a self-diagnosis you make from a symptom checklist on TikTok. Testosterone measurement in women is technically difficult: most commercial assays are calibrated for male reference ranges and lack sensitivity at female levels. Rosner et al. (2010, Journal of Clinical Endocrinology and Metabolism) specifically flagged this as a clinical problem. A proper workup includes total testosterone, free testosterone, DHEA-S, and SHBG, ideally drawn in the early follicular phase and confirmed on more than one occasion.
PCOS is a clinical diagnosis requiring at least two of three Rotterdam criteria: irregular ovulation, hyperandrogenism (biochemical or clinical), and polycystic ovarian morphology on ultrasound. Labs alone do not diagnose it. If PCOS is confirmed, the cardiometabolic risks she describes warrant real monitoring: fasting glucose, lipids, and blood pressure, alongside a clinician who is experienced with the condition.
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For Does PCOS actually cause high testosterone in women?, FormBlends checks the page topic against primary trials, systematic reviews, guidelines, and current PubMed-indexed literature where available. These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient.
Cardiovascular Safety of Testosterone-Replacement Therapy
TRAVERSE trial anchor for cardiovascular-safety discussions in appropriately diagnosed men.
PubMed
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline
Guideline anchor for diagnosis, monitoring, contraindications, and appropriate TRT framing.
PubMed
GLP-1 receptor agonists versus metformin in PCOS: a systematic review and meta-analysis
Used for PCOS pages comparing metabolic and weight-management approaches.
PubMed
The efficacy and safety of GLP-1 agonists in PCOS women living with obesity
Supports PCOS, obesity, and hormonal-regulation context.
PubMed
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Elevated androgens in women require a structured differential diagnosis before attributing them to PCOS, which is the most common but not the only cause.
FormBlends verdict
Elevated androgens in women require a structured differential diagnosis before attributing them to PCOS, which is the most common but not the only cause. Workup should include total and free testosterone, DHEA-S, SHBG, cortisol, and prolactin, with results interpreted in the context of cycle timing and validated assay methodology. Confirmed PCOS carries real cardiometabolic risk and warrants ongoing monitoring beyond symptom management.
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What it helps with
- Elevated androgens in women require a structured differential diagnosis before attributing them to PCOS, which is the most common but not the only cause. Workup should include total and free testosterone, DHEA-S, SHBG, cortisol, and prolactin, with results interpreted in the context of cycle timing and validated assay methodology. Confirmed PCOS carries real cardiometabolic risk and warrants ongoing monitoring beyond symptom management.
- PCOS affects 6-12% of reproductive-age women and is the leading cause of hyperandrogenism, per Rosenfield and Ehrmann (2018, NEJM).
- Insulin resistance is present in roughly 65-70% of women with PCOS regardless of body weight, according to Diamanti-Kandarakis and Dunaif (2012, Endocrine Reviews).
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- It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
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Start provider reviewWhat You'll Learn
- PCOS affects 6-12% of reproductive-age women and is the leading cause of hyperandrogenism, per Rosenfield and Ehrmann (2018, NEJM).
- Insulin resistance is present in roughly 65-70% of women with PCOS regardless of body weight, according to Diamanti-Kandarakis and Dunaif (2012, Endocrine Reviews).
- PCOS is a diagnosis of exclusion: congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's syndrome, and hyperprolactinemia must be ruled out before diagnosing PCOS.
- Commercial testosterone assays are often poorly calibrated for female reference ranges, making result interpretation unreliable without validated methodology (Rosner et al., 2010, JCEM).
- A PCOS diagnosis requires at least 2 of 3 Rotterdam criteria: irregular ovulation, hyperandrogenism, and polycystic ovarian morphology on ultrasound. Labs alone are insufficient.
- Confirmed PCOS warrants cardiometabolic monitoring including fasting glucose, lipid panel, and blood pressure, not just symptom treatment.
- The claim that PCOS causes difficulty gaining weight is not supported by the literature and appears to be a verbal error in the video.
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About the Creator
Dr. Jolene Brighten · TikTok creator
237.9K views on this video
Replying to @xtinaalexandraa what causes high testosterone in women? The most common cause is Polycystic Ovarian Syndrome or PCOS. #pcos #pcosawareness #pcosproblems #hightestosteroneinwomen #hormonehealth #hormoneimbalance #hirsutism #acne #hormonalacne
Sources & references
Citations extracted from our medical team's review. Click any citation to search PubMed.
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Not medical advice. This video was made by Dr. Jolene Brighten, not by FormBlends. Our write-up above is an editorial review, not a medical recommendation. Talk to your doctor before making any decisions about medications or treatments.