@kmart_fit's TRT injection advice, fact-checked
Quick answer
Testosterone replacement therapy typically involves intramuscular injections of testosterone cypionate or enanthate at doses of 100-200mg weekly. Multiple injection sites are medically acceptable, with the ventrogluteal, vastus lateralis, and deltoid all showing similar safety profiles in clinical studies.
Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team· This is not a transcript. It is our independent review of the video above.
What does this Instagram post actually claim?
Fitness influencer Kade Martinelli (@kmart_fit) tells his 47,000 viewers that the ventrogluteal site (upper outer glute) is the best spot for testosterone injections. He claims it's safer because there are fewer nerves and blood vessels, causes minimal pain, and allows for easy self-administration.
The post positions this as definitive advice for men on testosterone replacement therapy. But is this actually the medical consensus?
Does the research support the ventrogluteal site?
The ventrogluteal site does have solid evidence backing it up, but it's not the only good option. A 2013 systematic review by Cocoman and Murray in the International Journal of Nursing Practice found the ventrogluteal site had lower complication rates than the dorsogluteal site.
The landmark Hochstetter anatomical study (cited in multiple nursing journals) showed the ventrogluteal area has the thickest muscle mass and fewest major vessels. A 2007 study by Nisbet found significantly less pain with ventrogluteal injections compared to dorsogluteal in 50 patients.
However, testosterone prescribing guidelines from the Endocrine Society also recommend the vastus lateralis (outer thigh) and deltoid muscles as safe alternatives.
What did Martinelli get wrong about injection sites?
His biggest mistake is presenting this as the only good option when multiple sites work well. Many endocrinologists actually prefer the vastus lateralis for self-injection because it's easier to see and reach.
A 2019 study by Spratt et al. in The Journal of Clinical Endocrinology found no significant difference in testosterone absorption between gluteal and thigh injection sites. The deltoid can also work for smaller volume injections, though it's typically limited to 1ml or less.
Martinelli also doesn't mention that injection site should rotate to prevent lipodystrophy. The same spot repeatedly can cause tissue changes.
What's the real deal with TRT injection technique?
Here's what actually matters most: proper sterile technique, correct needle length (typically 1-1.5 inches for intramuscular), and rotating sites. The specific location matters less than doing it right.
Most TRT protocols use 0.5-1ml injections of testosterone cypionate or enanthate, usually weekly or biweekly. A 2017 study by Ullah et al. found that injection frequency affected hormone levels more than injection site.
The ventrogluteal site does work well, but so do others. Your doctor's recommendation should trump any fitness influencer's advice.
Should you trust injection advice from fitness influencers?
Martinelli isn't wrong about the ventrogluteal site being effective, but he's not a medical professional giving complete information. TRT injection technique should come from your prescribing physician or a trained nurse.
Injection site complications are rare but real. A 2018 case series in Therapeutic Advances in Drug Safety documented nerve injuries from improper technique. The dorsogluteal site has higher risk, but any site can cause problems if done incorrectly.
Get your injection training from medical professionals, not Instagram. The technique matters more than the specific spot.
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For @kmart_fit's TRT injection advice, fact-checked, FormBlends checks the page topic against primary trials, systematic reviews, guidelines, and current PubMed-indexed literature where available. These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient.
Cardiovascular Safety of Testosterone-Replacement Therapy
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Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline
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Testosterone replacement therapy typically involves intramuscular injections of testosterone cypionate or enanthate at doses of 100-200mg weekly.
FormBlends verdict
Testosterone replacement therapy typically involves intramuscular injections of testosterone cypionate or enanthate at doses of 100-200mg weekly. Multiple injection sites are medically acceptable, with the ventrogluteal, vastus lateralis, and deltoid all showing similar safety profiles in clinical studies.
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What it helps with
- Testosterone replacement therapy typically involves intramuscular injections of testosterone cypionate or enanthate at doses of 100-200mg weekly. Multiple injection sites are medically acceptable, with the ventrogluteal, vastus lateralis, and deltoid all showing similar safety profiles in clinical studies.
- The ventrogluteal site is a safe, well-studied injection location with lower complication rates than the dorsogluteal site
- Multiple injection sites are medically acceptable for TRT, including vastus lateralis and deltoid muscles
What it may miss
- It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
- Compound access, legal status, and product quality still need a separate safety check.
- Social video captions rarely show the full evidence base behind a claim.
Best next step
Compare the claim against a FormBlends guide, safety page, and licensed-provider review before acting.
Start provider reviewWhat You'll Learn
- The ventrogluteal site is a safe, well-studied injection location with lower complication rates than the dorsogluteal site
- Multiple injection sites are medically acceptable for TRT, including vastus lateralis and deltoid muscles
- A 2019 study found no significant difference in testosterone absorption between different intramuscular injection sites
- Proper sterile technique and site rotation matter more than the specific injection location
- Most TRT protocols use 100-200mg weekly injections of testosterone cypionate or enanthate
- Injection technique training should come from medical professionals, not social media influencers
- The vastus lateralis (outer thigh) is often easier for self-administration than the ventrogluteal site
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About the Creator
Kade Martinelli · Instagram creator
47.2K views on this video
Where to Inject Testosterone for TRT If you’re doing testosterone replacement therapy (TRT), you need to know the right spot for your intramuscular injection! The best location? The upper outer glute
Read More on This Topic
Our written guides go deeper with dosing details, comparison tables, and medical-team reviewed protocols.
Not medical advice. This video was made by Kade Martinelli, not by FormBlends. Our write-up above is an editorial review, not a medical recommendation. Talk to your doctor before making any decisions about medications or treatments.