What does this TikTok actually claim?
Coach Darian Bates argues that TRT doesn't cause hair loss in men who aren't genetically predisposed to male pattern baldness. Instead, he claims testosterone replacement therapy simply accelerates hair loss in those already destined to go bald.
He also warns against blocking DHT (dihydrotestosterone) to preserve hair, saying it'll tank your mood and libido. According to Bates, DHT is responsible for much of the positive effects men feel on TRT.
Does genetics really determine TRT hair loss?
Bates gets this mostly right. Androgenetic alopecia (male pattern baldness) requires both androgens like DHT and genetic susceptibility to occur. The key gene is the androgen receptor gene, with certain variants making hair follicles more sensitive to DHT.
A 2017 meta-analysis by Heilmann-Heimbach et al. in Nature Communications identified 63 genetic loci associated with male pattern baldness. Men without these genetic variants can handle higher DHT levels without significant hair loss.
However, TRT can still affect hair in genetically resistant men. Higher testosterone levels mean more substrate for 5-alpha reductase to convert into DHT, potentially causing some thinning even in men with "good" hair genes.
What happens when you block DHT?
This is where Bates oversimplifies things. DHT blockers like finasteride don't universally destroy mood and libido, though some men do experience these side effects.
The PROECIA trial data showed that 1.8% of men on 1mg finasteride experienced decreased libido versus 1.3% on placebo. Post-finasteride syndrome, where sexual side effects persist after stopping the drug, affects a small subset of users but remains poorly understood.
Bates is correct that DHT contributes to TRT's positive effects. DHT is five times more potent than testosterone at androgen receptors and plays a role in mood, cognitive function, and sexual health. But blocking it isn't automatically a "shit trade off" for every man.
What's the real DHT story on TRT?
DHT levels typically increase 14-50% on testosterone replacement therapy, depending on the protocol and individual 5-alpha reductase activity. This enzyme converts testosterone to DHT primarily in the prostate, skin, and hair follicles.
Men on TRT who want to preserve hair have several options beyond complete DHT suppression. Topical finasteride reduces scalp DHT while minimizing systemic effects. Dutasteride blocks both type 1 and type 2 5-alpha reductase but carries higher risk of sexual side effects.
Some men use DHT derivatives like Proviron alongside finasteride to maintain androgenic effects while protecting hair. Others accept some hair loss as part of their treatment goals.
What should you actually know about TRT and hair?
Bates simplifies a complex topic but hits the main points correctly. Your genetics largely determine whether TRT will accelerate hair loss, and DHT does contribute to the positive effects men seek from testosterone therapy.
However, the choice isn't binary between keeping hair and feeling good. Many men successfully use DHT inhibitors without significant side effects. Others prioritize the full androgenic effects of TRT over hair preservation.
The decision should involve discussing your family history of baldness, treatment goals, and risk tolerance with a knowledgeable provider. Cookie-cutter advice from fitness coaches, even well-intentioned ones, can't replace individualized medical guidance.