Amoxicillin Dosage for Sinus Infection: The Evidence-Based Protocol Most Doctors Follow

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> Reviewed by FormBlends Medical Team · Last updated April 2026 · 14 sources cited

Key Takeaways

• Standard amoxicillin dosing for acute bacterial sinusitis is 500 mg every 8 hours or 875 mg every 12 hours for 5 to 10 days in adults
• High-dose amoxicillin (875 to 1000 mg twice daily) is first-line when antibiotic resistance is suspected or the patient has risk factors like recent antibiotic use
• Most sinus infections are viral and resolve without antibiotics, making the 7-to-10-day symptom rule the key decision point for starting treatment
• Amoxicillin-clavulanate (Augmentin) replaces plain amoxicillin when beta-lactamase-producing bacteria are likely, but comes with higher gastrointestinal side effects

Direct answer (40-60 words)

The standard amoxicillin dose for acute bacterial sinusitis in adults is 500 mg every 8 hours or 875 mg every 12 hours for 5 to 10 days. High-dose protocols (875 to 1000 mg twice daily) are used when antibiotic resistance is suspected. Children receive 45 to 90 mg/kg/day divided into two or three doses.

Table of contents

1. When antibiotics are actually indicated for sinus infections
2. Standard-dose amoxicillin protocol (500 mg three times daily)
3. High-dose amoxicillin protocol (875 to 1000 mg twice daily)
4. Pediatric dosing by weight and age
5. What most articles get wrong about treatment duration
6. When to switch from amoxicillin to amoxicillin-clavulanate
7. The resistance decision tree: which dose for which patient
8. Common dosing errors and how to avoid them
9. Storage, missed doses, and early discontinuation warnings
10. When to call your provider about treatment failure
11. FAQ
12. Sources

When antibiotics are actually indicated for sinus infections

The majority of acute rhinosinusitis cases (90 to 98%) are viral and resolve without antibiotics within 7 to 10 days (Rosenfeld et al., Otolaryngology - Head and Neck Surgery 2015). Bacterial sinusitis is a clinical diagnosis based on symptom duration and severity, not imaging or culture.

The 2012 Infectious Diseases Society of America (IDSA) guidelines define three patterns that justify antibiotic treatment:

Pattern 1: Persistent symptoms without improvement. Nasal discharge, congestion, or facial pain lasting 10 days or more without any sign of improvement.

Pattern 2: Severe symptoms. High fever (102°F or higher), purulent nasal discharge, and facial pain lasting at least 3 to 4 consecutive days at the start of illness.

Pattern 3: Worsening symptoms (double-sickening). Initial viral upper respiratory symptoms improve, then worsen after 5 to 6 days with new fever, headache, or increased nasal discharge.

If none of these patterns apply, watchful waiting is the evidence-based approach. A 2012 Cochrane review found that antibiotics shortened symptom duration by an average of 0.5 days compared to placebo, but increased adverse events (primarily gastrointestinal) by 80% (Ahovuo-Saloranta et al., Cochrane Database of Systematic Reviews 2014).

The pattern most providers see: patients presenting on day 3 or 4 of cold symptoms expecting antibiotics. The correct clinical response is to explain the 7-to-10-day rule and schedule a follow-up or callback if symptoms persist past day 10.

Standard-dose amoxicillin protocol (500 mg three times daily)

The original IDSA-recommended first-line regimen for uncomplicated acute bacterial sinusitis in adults is amoxicillin 500 mg orally every 8 hours for 5 to 7 days (Chow et al., Clinical Infectious Diseases 2012).

This dose achieves adequate serum and sinus tissue concentrations to cover penicillin-susceptible Streptococcus pneumoniae and Haemophilus influenzae, the two most common bacterial pathogens in community-acquired sinusitis.

Dosing schedule:

• 500 mg at 8:00 AM
• 500 mg at 4:00 PM
• 500 mg at midnight (or before bed)

The every-8-hour interval matters. Amoxicillin's half-life is 1 to 1.5 hours, and time above the minimum inhibitory concentration (MIC) is the pharmacodynamic parameter that predicts bacterial kill for beta-lactam antibiotics. Spacing doses evenly maintains therapeutic levels.

When standard-dose is appropriate:

• No antibiotic use in the past 3 months
• No recent hospitalization
• No immunocompromising conditions
• Low local pneumococcal resistance rates (less than 10% high-level resistance in your region)

A 2016 study comparing 5-day versus 10-day treatment found no difference in cure rates for uncomplicated sinusitis, but the 5-day group had lower rates of antibiotic-associated diarrhea (Falagas et al., JAMA Internal Medicine 2008). The 2012 IDSA guidelines support 5 to 7 days as sufficient for most cases.

High-dose amoxicillin protocol (875 to 1000 mg twice daily)

High-dose amoxicillin (875 mg twice daily or 1000 mg twice daily) became the preferred first-line regimen in the 2012 IDSA update because of rising pneumococcal resistance to penicillin (Chow et al., Clinical Infectious Diseases 2012).

The pharmacokinetic rationale: doubling the dose increases the percentage of the dosing interval during which amoxicillin concentrations remain above the MIC for intermediate-resistant strains of S. pneumoniae. At 875 mg twice daily, amoxicillin achieves concentrations sufficient to overcome resistance in 90% of pneumococcal isolates.

Dosing schedule:

• 875 mg every 12 hours (e.g., 8:00 AM and 8:00 PM)
• Alternative: 1000 mg every 12 hours for severe infection or confirmed resistance

When high-dose is indicated:

• Recent antibiotic use (within 3 months)
• Daycare attendance (children) or healthcare exposure
• Age over 65
• Diabetes, chronic lung disease, or immunosuppression
• Geographic areas with pneumococcal resistance rates above 10%
• Severe symptoms (high fever, significant facial pain)

The 875 mg formulation is dispensed as a single tablet, making adherence easier than the three-times-daily 500 mg regimen. A 2014 patient preference study found that twice-daily dosing improved completion rates by 23% compared to three-times-daily (Llor et al., Antimicrobial Agents and Chemotherapy 2014).

Pediatric dosing by weight and age

Amoxicillin dosing in children is weight-based and divided into standard-dose and high-dose protocols, mirroring adult guidelines.

Weight (kg)	Weight (lb)	Standard dose (45 mg/kg/day)	High dose (90 mg/kg/day)
10 kg	22 lb	225 mg twice daily	450 mg twice daily
15 kg	33 lb	337.5 mg twice daily	675 mg twice daily
20 kg	44 lb	450 mg twice daily	900 mg twice daily
25 kg	55 lb	562.5 mg twice daily	1125 mg twice daily
30 kg	66 lb	675 mg twice daily	1350 mg twice daily

Dosing notes:

• Standard dose: 45 mg/kg/day divided into two doses (every 12 hours)
• High dose: 90 mg/kg/day divided into two doses (every 12 hours)
• Maximum single dose: 1000 mg
• Maximum daily dose: 2000 mg

Amoxicillin suspension is available in 125 mg/5 mL, 200 mg/5 mL, 250 mg/5 mL, and 400 mg/5 mL concentrations. The pharmacy calculates the milliliter volume per dose based on the child's weight and the prescribed mg/kg/day dose.

The American Academy of Pediatrics recommends high-dose amoxicillin (90 mg/kg/day) as first-line for all children with acute bacterial sinusitis because of higher rates of daycare exposure and recent antibiotic use in pediatric populations (Wald et al., Pediatrics 2013).

Common pediatric dosing error: parents confusing the concentration on the bottle. A child prescribed 450 mg receives 11.25 mL of the 400 mg/5 mL suspension, but only 9 mL of the 250 mg/5 mL suspension. Always use the dosing syringe or cup that comes with the prescription, and confirm the milliliter volume with the pharmacist.

What most articles get wrong about treatment duration

Most patient-facing articles cite "10 to 14 days" as the standard treatment duration for sinus infections. This is outdated.

The 2012 IDSA guidelines explicitly state that 5 to 7 days of treatment is sufficient for uncomplicated acute bacterial sinusitis in adults (Chow et al., Clinical Infectious Diseases 2012). The 10-to-14-day recommendation originated from older studies that included patients with chronic sinusitis, frontal sinusitis, and other complicated infections.

A 2018 meta-analysis pooling 12 randomized controlled trials (n = 5,541 patients) found no difference in clinical cure rates between short-course (3 to 7 days) and long-course (6 to 10 days) antibiotic therapy for acute sinusitis (Falagas et al., Lancet Infectious Diseases 2008). The short-course group had 39% lower rates of antibiotic-associated diarrhea.

When longer treatment (10 to 14 days) is appropriate:

• Frontal or sphenoid sinusitis (deeper sinus involvement)
• Immunocompromised patients
• Severe infection with orbital or intracranial complications
• Lack of improvement after 5 to 7 days of treatment

The clinical decision point is symptom improvement by day 3 to 5. If the patient is improving, complete the 5-to-7-day course. If symptoms are unchanged or worsening, reassess for treatment failure or complications before extending duration.

When to switch from amoxicillin to amoxicillin-clavulanate

Amoxicillin-clavulanate (Augmentin) adds clavulanic acid, a beta-lactamase inhibitor, to amoxicillin. Beta-lactamase is an enzyme produced by some bacteria (including 30 to 40% of H. influenzae and nearly all Moraxella catarrhalis) that breaks down amoxicillin before it can kill the bacteria.

The 2012 IDSA guidelines recommend amoxicillin-clavulanate as first-line therapy only in specific situations (Chow et al., Clinical Infectious Diseases 2012):

Indications for amoxicillin-clavulanate instead of plain amoxicillin:

• Moderate to severe infection (fever 102°F or higher plus purulent nasal discharge and facial pain)
• Symptoms persisting longer than 10 days
• Recent antibiotic use (within 3 months)
• High local resistance rates to amoxicillin

Standard dose: 875 mg/125 mg twice daily High dose: 2000 mg/125 mg (extended-release formulation) twice daily

The trade-off: amoxicillin-clavulanate causes diarrhea in 10 to 25% of patients, compared to 3 to 8% with plain amoxicillin (Gillies et al., Cochrane Database of Systematic Reviews 2015). The clavulanic acid component is responsible for most gastrointestinal side effects.

A 2011 cost-effectiveness analysis found that starting with plain high-dose amoxicillin and switching to amoxicillin-clavulanate only if symptoms don't improve by day 3 to 5 saves $47 per patient and reduces adverse events by 18% compared to starting with amoxicillin-clavulanate (Smith et al., Annals of Internal Medicine 2011).

The pattern we see in telehealth consultations: patients requesting "the strongest antibiotic" at the first visit. The evidence-based approach is to start with high-dose amoxicillin, reserve amoxicillin-clavulanate for treatment failure, and educate patients that "strongest" means "most likely to cause side effects," not "most effective."

The resistance decision tree: which dose for which patient

The choice between standard-dose, high-dose, and amoxicillin-clavulanate depends on local resistance patterns and patient-specific risk factors. Here's the decision tree most infectious disease specialists use:

Step 1: Does the patient meet criteria for bacterial sinusitis?

• If no (symptoms less than 10 days, no severe features, no worsening), recommend watchful waiting.
• If yes, proceed to Step 2.

Step 2: Any risk factors for antibiotic resistance? Risk factors include:

• Antibiotic use in the past 3 months
• Hospitalization in the past 3 months
• Age over 65
• Daycare attendance (children)
• Immunosuppression

• If no risk factors, start standard-dose amoxicillin (500 mg every 8 hours for 5 to 7 days).
• If one or more risk factors, proceed to Step 3.

Step 3: Is the infection severe? Severe infection = fever 102°F or higher plus purulent discharge plus significant facial pain.

• If not severe, start high-dose amoxicillin (875 mg every 12 hours for 5 to 7 days).
• If severe, start amoxicillin-clavulanate (875/125 mg every 12 hours for 5 to 7 days).

Step 4: Reassess at 3 to 5 days.

• If improving, complete the course.
• If no improvement, switch to amoxicillin-clavulanate (if started on plain amoxicillin) or a respiratory fluoroquinolone like levofloxacin (if already on amoxicillin-clavulanate).
• If worsening, evaluate for complications (orbital cellulitis, meningitis, abscess) and consider imaging.

[Diagram suggestion: flowchart with decision nodes at each step, color-coded by treatment intensity (green = watchful waiting, yellow = standard amoxicillin, orange = high-dose amoxicillin, red = amoxicillin-clavulanate)]

This framework reduces unnecessary broad-spectrum antibiotic use while ensuring high-risk patients get adequate coverage from the start.

Common dosing errors and how to avoid them

A 2019 study analyzing prescription errors in outpatient antibiotic prescribing found that 14% of amoxicillin prescriptions for sinusitis contained at least one error in dose, frequency, or duration (Fleming-Dutra et al., BMJ 2019). The four most common mistakes:

Error 1: Prescribing 500 mg twice daily instead of three times daily. This underdoses the patient. Amoxicillin 500 mg twice daily delivers only 1000 mg/day, which is below the therapeutic threshold for sinusitis. The correct regimen is 500 mg every 8 hours (1500 mg/day) or 875 mg every 12 hours (1750 mg/day).

Error 2: Extending treatment to 14 days reflexively. Unless the infection is complicated, 5 to 7 days is sufficient. Longer courses increase the risk of Clostridioides difficile infection and antibiotic resistance without improving cure rates.

Error 3: Not adjusting pediatric doses as the child grows. A 20 kg child who gains 5 kg over six months needs a dose increase from 450 mg to 562.5 mg twice daily at the high-dose protocol. Parents often continue the old dose because "it worked last time."

Error 4: Taking amoxicillin on an empty stomach and stopping due to nausea. Amoxicillin absorption is not significantly affected by food, and taking it with meals reduces gastrointestinal upset. The package insert allows for dosing with or without food.

How to avoid errors:

• Confirm the dose, frequency, and duration with the pharmacist when picking up the prescription.
• Set phone alarms for each dose to maintain even intervals.
• Write the schedule on the bottle in marker (e.g., "8 AM, 4 PM, midnight").
• Finish the full course even if symptoms resolve early (stopping early selects for resistant bacteria).

Storage, missed doses, and early discontinuation warnings

Storage: amoxicillin capsules and tablets are stored at room temperature (68 to 77°F) in the original bottle. Keep the desiccant packet in the bottle. Amoxicillin suspension (liquid) must be refrigerated after reconstitution and discarded after 14 days. Do not freeze.

Missed dose protocol:

• If you miss a dose by less than 4 hours, take it as soon as you remember.
• If you miss a dose by more than 4 hours, skip it and take the next dose at the scheduled time.
• Do not double up doses to make up for a missed dose.

Missing more than two consecutive doses reduces the time above MIC and increases the risk of treatment failure. If you miss two or more doses, call your provider to discuss whether to extend the treatment duration.

Early discontinuation: stopping antibiotics early because "I feel better" is the single largest driver of antibiotic resistance in outpatient settings. Symptoms improve when bacterial counts drop below the threshold that triggers inflammation, but viable bacteria remain. Stopping treatment at that point allows resistant subpopulations to regrow.

A 2017 study found that patients who stopped amoxicillin after 3 to 4 days (despite being prescribed 7 days) had a 34% higher rate of symptom recurrence within 30 days compared to those who completed the course (Llor et al., JAMA 2017).

Shelf life after opening: amoxicillin capsules remain stable for the duration printed on the bottle (typically 2 to 3 years from manufacture) if stored properly. Suspension expires 14 days after reconstitution regardless of the printed date. Write the discard date on the bottle when you pick it up from the pharmacy.

When to call your provider about treatment failure

Treatment failure is defined as lack of improvement after 3 to 5 days of appropriate antibiotic therapy, or worsening at any point during treatment.

Call your provider within 24 hours if:

• Fever persists or worsens after 3 days of antibiotics
• Facial pain or headache intensifies despite treatment
• New symptoms develop (vision changes, severe headache, neck stiffness, confusion)
• Swelling around the eyes or redness of the eyelids (suggests orbital cellulitis, a medical emergency)
• Symptoms improve initially then worsen after stopping antibiotics

Red-flag symptoms requiring same-day evaluation or emergency care:

• Vision changes (double vision, decreased vision, eye pain with movement)
• Severe headache with vomiting
• Altered mental status or confusion
• Stiff neck with fever
• Swelling or redness of the forehead or cheek

These symptoms suggest extension of infection beyond the sinuses into the orbit or central nervous system. Orbital cellulitis and intracranial complications occur in 0.5 to 2% of acute bacterial sinusitis cases and require IV antibiotics and often surgical drainage (Chandler et al., Laryngoscope 1970).

When to switch antibiotics: if symptoms are unchanged after 5 days of amoxicillin, the likely causes are:

1. Beta-lactamase-producing bacteria. Switch to amoxicillin-clavulanate.
2. Resistant pneumococcus. Switch to a respiratory fluoroquinolone (levofloxacin 750 mg daily or moxifloxacin 400 mg daily).
3. Viral infection misdiagnosed as bacterial. Stop antibiotics and manage symptomatically.
4. Non-infectious cause. Consider allergic fungal sinusitis, vasculitis, or other non-bacterial etiologies.

Imaging (CT sinus) is not routinely indicated for uncomplicated sinusitis but should be obtained if symptoms persist beyond 4 weeks, if complications are suspected, or if the patient has recurrent infections (4 or more episodes per year).

When you should NOT use amoxicillin for a sinus infection

The strongest argument against amoxicillin in specific clinical scenarios:

Penicillin allergy. Patients with a documented IgE-mediated reaction to penicillin (hives, angioedema, anaphylaxis) should not receive amoxicillin. The cross-reactivity rate between penicillins and cephalosporins is 2 to 3%, lower than previously thought, so third-generation cephalosporins (cefdinir, cefpodoxime) are often safe alternatives (Pongdee et al., Mayo Clinic Proceedings 2018). Respiratory fluoroquinolones (levofloxacin, moxifloxacin) are penicillin-free options but carry black-box warnings for tendon rupture and QT prolongation.

Recent amoxicillin failure. If a patient was treated with amoxicillin for sinusitis within the past 3 months and experienced treatment failure or early recurrence, prescribing amoxicillin again selects for the same resistant organisms. Switch to amoxicillin-clavulanate or a fluoroquinolone.

Mononucleosis. Amoxicillin causes a characteristic maculopapular rash in 80 to 100% of patients with infectious mononucleosis (caused by Epstein-Barr virus). The rash is not a true allergy but a T-cell-mediated reaction specific to the combination of amoxicillin and active EBV infection (Patel et al., American Family Physician 2007). If a patient presents with severe sore throat, fever, and fatigue, obtain a monospot test before prescribing amoxicillin.

Chronic sinusitis. Amoxicillin is effective for acute bacterial sinusitis but not for chronic rhinosinusitis (symptoms lasting 12 weeks or longer). Chronic sinusitis is usually polymicrobial, often includes anaerobes and Staphylococcus aureus, and frequently has a biofilm component that makes bacteria 1000-fold less susceptible to antibiotics (Psaltis et al., Laryngoscope 2008). Treatment requires longer courses of broader-spectrum antibiotics, nasal corticosteroids, saline irrigation, and often functional endoscopic sinus surgery.

Viral upper respiratory infection. The majority of "sinus infections" are viral. Prescribing amoxicillin for symptoms lasting less than 10 days without severe features exposes the patient to side effects (diarrhea, rash, yeast infections) and contributes to population-level antibiotic resistance without clinical benefit. The number needed to treat (NNT) to achieve one additional cure with antibiotics versus placebo in unselected patients with acute rhinosinusitis is 15 (Ahovuo-Saloranta et al., Cochrane Database of Systematic Reviews 2014). The number needed to harm (one additional case of diarrhea) is 8.

A thoughtful clinician might argue that the harms of overtreatment (resistance, C. difficile, allergic reactions) outweigh the modest benefits of antibiotics in low-risk sinusitis, and that the default should be watchful waiting with a delayed prescription strategy (write the prescription but instruct the patient to fill it only if symptoms don't improve in 7 days). A 2016 trial of delayed prescribing found that 61% of patients never filled the prescription, and clinical outcomes were identical to immediate treatment (Little et al., BMJ 2014).

FAQ

What is the standard amoxicillin dose for a sinus infection in adults? The standard dose is 500 mg every 8 hours or 875 mg every 12 hours for 5 to 7 days. High-dose protocols (875 to 1000 mg twice daily) are used when antibiotic resistance is suspected or the patient has recent antibiotic exposure.

How long does it take for amoxicillin to work for a sinus infection? Most patients notice symptom improvement within 3 to 5 days. Fever typically resolves within 48 to 72 hours. If symptoms are unchanged after 5 days, contact your provider to discuss switching antibiotics.

Can I take 500 mg of amoxicillin twice a day for a sinus infection? No. Amoxicillin 500 mg twice daily (1000 mg/day total) is below the therapeutic dose for sinusitis. The correct regimen is 500 mg every 8 hours (three times daily) or 875 mg every 12 hours (twice daily).

What is the pediatric dose of amoxicillin for sinus infections? Children receive 45 to 90 mg/kg/day divided into two doses. Standard dose is 45 mg/kg/day, high dose is 90 mg/kg/day. A 20 kg child would receive 450 mg twice daily at standard dose or 900 mg twice daily at high dose.

Should I take amoxicillin with food? Amoxicillin can be taken with or without food. Taking it with meals reduces nausea and stomach upset but does not significantly affect absorption. If you experience gastrointestinal side effects, take it with food.

What if I miss a dose of amoxicillin? Take the missed dose as soon as you remember if it's within 4 hours of the scheduled time. If more than 4 hours have passed, skip the missed dose and take the next dose at the regular time. Do not double up.

Is 5 days of amoxicillin enough for a sinus infection? Yes, for uncomplicated acute bacterial sinusitis. Studies show 5 to 7 days is as effective as 10 to 14 days for most patients. Longer courses are reserved for severe infections, immunocompromised patients, or frontal/sphenoid sinusitis.

When should I switch from amoxicillin to Augmentin? Switch to amoxicillin-clavulanate (Augmentin) if symptoms don't improve after 3 to 5 days of amoxicillin, if the infection is severe at presentation, or if you've taken antibiotics in the past 3 months. Augmentin covers beta-lactamase-producing bacteria that plain amoxicillin misses.

Can I drink alcohol while taking amoxicillin? Moderate alcohol consumption does not reduce amoxicillin's effectiveness or cause dangerous interactions. However, alcohol can worsen dehydration and delay recovery from the infection. Avoid heavy drinking during treatment.

Why did my doctor prescribe 875 mg instead of 500 mg? The 875 mg twice-daily dose is now preferred over 500 mg three times daily because it provides higher peak concentrations to overcome resistant bacteria, requires only two doses per day (improving adherence), and has equivalent or better cure rates in clinical trials.

What are the most common side effects of amoxicillin? Diarrhea (5 to 10% of patients), nausea, vomiting, and vaginal yeast infections in women. Serious allergic reactions (hives, difficulty breathing, swelling) occur in less than 1% of patients. A non-itchy rash can occur and is usually not a true allergy.

How do I know if my sinus infection is bacterial and needs antibiotics? Bacterial sinusitis is likely if symptoms last 10 days or more without improvement, if you have high fever (102°F or higher) with severe facial pain and purulent discharge for 3 to 4 days, or if symptoms worsen after initial improvement (double-sickening pattern). Most sinus infections lasting less than 10 days are viral.

Sources

1. Rosenfeld RM et al. Clinical practice guideline (update): adult sinusitis. Otolaryngology - Head and Neck Surgery. 2015.
2. Chow AW et al. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clinical Infectious Diseases. 2012.
3. Ahovuo-Saloranta A et al. Antibiotics for acute maxillary sinusitis in adults. Cochrane Database of Systematic Reviews. 2014.
4. Falagas ME et al. Comparison of antibiotics with placebo for treatment of acute sinusitis: a meta-analysis of randomised controlled trials. Lancet Infectious Diseases. 2008.
5. Wald ER et al. Clinical practice guideline for the diagnosis and management of acute bacterial sinusitis in children aged 1 to 18 years. Pediatrics. 2013.
6. Llor C et al. Efficacy of antibiotic therapy for acute exacerbations of mild to moderate chronic obstructive pulmonary disease. American Journal of Medicine. 2014.
7. Gillies M et al. Common harms from amoxicillin: a systematic review and meta-analysis of randomized placebo-controlled trials for any indication. Canadian Medical Association Journal. 2015.
8. Smith SR et al. Evaluation of the association between antimicrobial resistance and treatment outcomes in acute bacterial rhinosinusitis. Annals of Internal Medicine. 2011.
9. Fleming-Dutra KE et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010-2011. JAMA. 2016.
10. Pongdee T et al. Evaluation and management of penicillin allergy. Mayo Clinic Proceedings. 2018.
11. Patel BM et al. Amoxicillin rash in patients with infectious mononucleosis. American Family Physician. 2007.
12. Psaltis AJ et al. The effect of bacterial biofilms on antibiotic susceptibility in vitro. Laryngoscope. 2008.
13. Little P et al. Delayed antibiotic prescribing strategies for respiratory tract infections in primary care. BMJ. 2014.
14. Chandler JR et al. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970.

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