How Much Reconstitution Solution for 10 mg Semaglutide: The Complete Mixing Guide

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> Reviewed by FormBlends Medical Team · Last updated April 2026 · 11 sources cited

Key Takeaways

• For a 10 mg semaglutide vial, 2 mL of bacteriostatic water creates a 5 mg/mL concentration (the most common standard), making dose math simple and readable on U-100 insulin syringes
• The concentration you create during reconstitution determines every subsequent injection volume for the life of that vial, so the initial mixing step is the single highest-use moment in your dosing accuracy
• Most compounding pharmacies recommend 2 mL for 10 mg vials, but some protocols use 1 mL (creating 10 mg/mL) or 4 mL (creating 2.5 mg/mL) depending on patient dose range and injection volume preferences
• Bacteriostatic water (0.9% benzyl alcohol) is required, not sterile water, because multi-dose vials need preservative protection against bacterial contamination across 28 days of repeated punctures

Direct answer (40-60 words)

For a 10 mg lyophilized semaglutide vial, add 2 mL of bacteriostatic water to create a 5 mg/mL concentration. This is the standard protocol at most U.S. compounding pharmacies. The 5 mg/mL concentration makes dose calculations straightforward: 0.25 mg equals 5 units, 0.5 mg equals 10 units, 1 mg equals 20 units on a U-100 insulin syringe.

Table of contents

1. Why reconstitution volume matters more than vial size
2. The three standard concentrations for 10 mg semaglutide vials
3. Step-by-step reconstitution protocol for 10 mg vials
4. Concentration decision tree: which volume is right for your dose range
5. What most articles get wrong about "standard" reconstitution
6. Dose conversion charts for all three concentrations
7. The 72-hour clarity test and when to discard a vial
8. Reconstitution errors that change your dose by 50% or more
9. Storage, stability, and the 28-day clock
10. When to contact your pharmacy about reconstitution
11. FAQ
12. Sources

Why reconstitution volume matters more than vial size

Lyophilized (freeze-dried) semaglutide arrives as a white or off-white powder in a sealed vial. The powder has no inherent concentration until you add bacteriostatic water. The volume of water you add creates the concentration, and the concentration determines how many units you draw for every milligram dose.

A 10 mg vial reconstituted with 2 mL of bacteriostatic water becomes a 5 mg/mL solution. The same 10 mg vial reconstituted with 1 mL becomes 10 mg/mL. With 4 mL it becomes 2.5 mg/mL. All three are correct reconstitutions of the same vial. The "right" volume depends on your prescribed dose range and injection volume tolerance.

This is different from pre-mixed liquid semaglutide, where the pharmacy sets the concentration and you just draw the dose. With lyophilized product, you're the one creating the concentration, which means you're also the one who can create a dosing error if the reconstitution volume is wrong.

The math is simple: divide the total milligrams in the vial by the milliliters of water you add. 10 mg divided by 2 mL equals 5 mg/mL. But simple math done wrong at the reconstitution step compounds across every injection for the next four weeks.

The three standard concentrations for 10 mg semaglutide vials

Most compounding pharmacies recommend one of three reconstitution volumes for 10 mg vials. Each creates a different concentration with different unit-per-dose math.

Bacteriostatic water added	Final concentration	Best for	Pros	Cons
1 mL	10 mg/mL	High-dose patients (2 mg and above)	Smallest injection volume; clean 1:10 mg-to-unit ratio	Doses below 0.5 mg require drawing fewer than 5 units, hard to read accurately
2 mL	5 mg/mL	Most patients (0.25 mg to 2 mg range)	Balanced; doses land on easy-to-read unit markings	Requires 0.4 mL injection for 2 mg dose (slightly larger volume)
4 mL	2.5 mg/mL	Low-dose or titration-sensitive patients	Very small starting doses (0.25 mg = 10 units, easy to read)	Large injection volumes at higher doses; 2 mg = 80 units

The 2 mL standard (5 mg/mL) is the most common because it balances injection volume against syringe readability across the full FDA-studied dose range (0.25 mg to 2.4 mg weekly). At 5 mg/mL, every 0.1 mg of semaglutide equals 2 units on a U-100 syringe, so most doses land on even unit markings.

The 1 mL option (10 mg/mL) is used when patients are at maintenance doses of 1.7 mg or 2.4 mg and want the smallest possible injection volume. At 10 mg/mL, a 2.4 mg dose is 24 units (0.24 mL), half the volume of the same dose at 5 mg/mL.

The 4 mL option (2.5 mg/mL) is occasionally used during initial titration when patients are at 0.25 mg and the provider wants maximum syringe readability. At 2.5 mg/mL, 0.25 mg equals 10 units, which is easier to draw accurately than 5 units. But once the patient titrates above 1 mg, the injection volumes get large enough (40+ units) that most switch to a higher concentration.

Step-by-step reconstitution protocol for 10 mg vials

This protocol assumes you're reconstituting with 2 mL of bacteriostatic water to create a 5 mg/mL concentration. Adjust the water volume if your pharmacy instructions specify 1 mL or 4 mL.

Materials needed:

• One 10 mg lyophilized semaglutide vial
• One 30 mL vial of bacteriostatic water (0.9% benzyl alcohol)
• One 3 mL syringe with needle (18-gauge or 20-gauge for drawing, not for injection)
• Alcohol swabs
• Sharps container

Steps:

1. Wash your hands thoroughly with soap and water for at least 20 seconds.

1. Inspect both vials. The semaglutide powder should be white to off-white with no discoloration. The bacteriostatic water should be clear. If either looks wrong, don't use it.

1. Remove the plastic caps from both vials. Wipe both rubber stoppers with separate alcohol swabs. Let air-dry for 10 seconds.

1. Draw 2 mL of bacteriostatic water. Insert the needle into the bacteriostatic water vial. Pull back the plunger to the 2 mL mark. Check for air bubbles. If present, push the water back into the vial and re-draw.

1. Add water to the semaglutide vial slowly. Insert the needle into the semaglutide vial. Aim the stream of water at the inside wall of the vial, not directly at the powder. Push the plunger slowly. The goal is to let the water run down the wall and dissolve the powder gently.

1. Swirl, don't shake. Remove the needle. Swirl the vial gently in a circular motion for 30 to 60 seconds. The powder should dissolve completely. Don't shake the vial. Semaglutide is a peptide and shaking can cause aggregation (clumping), which reduces effectiveness.

1. Inspect the reconstituted solution. Hold the vial up to light. The liquid should be clear and colorless to faintly yellow. No visible particles, no cloudiness. If you see particles or cloudiness, don't use it. Contact the pharmacy.

1. Label the vial. Write the reconstitution date and concentration on the vial with a permanent marker. "5 mg/mL, mixed [date]." This prevents confusion if you're reconstituting multiple vials.

1. Refrigerate immediately. Store at 36 to 46°F (2 to 8°C). The 28-day stability clock starts now.

The entire process takes about 3 minutes. Most patients find it easier than expected after the first attempt. The hardest part is injecting the water slowly enough that you don't create foam.

Concentration decision tree: which volume is right for your dose range

Use this decision tree if your pharmacy gave you a 10 mg vial without specifying reconstitution volume, or if you're switching from pre-mixed to lyophilized and need to choose a concentration.

Start here: What is your current prescribed weekly dose?

• 0.25 mg or 0.5 mg (titration phase): Reconstitute with 2 mL or 4 mL. At 2 mL (5 mg/mL), your doses are 5 units and 10 units. At 4 mL (2.5 mg/mL), your doses are 10 units and 20 units. Choose 4 mL if you have trouble reading small unit markings or if you're using a 0.3 mL syringe with half-unit markings.

• 1 mg (common maintenance dose): Reconstitute with 2 mL (5 mg/mL). Your dose is 20 units, which is easy to read on any U-100 syringe and a comfortable injection volume (0.2 mL).

• 1.7 mg or 2 mg (higher maintenance doses): Reconstitute with 1 mL or 2 mL. At 2 mL (5 mg/mL), your 2 mg dose is 40 units (0.4 mL). At 1 mL (10 mg/mL), your 2 mg dose is 20 units (0.2 mL). Choose 1 mL if you want smaller injection volumes.

• 2.4 mg (maximum FDA-studied dose): Reconstitute with 1 mL (10 mg/mL). Your dose is 24 units (0.24 mL). At 2 mL (5 mg/mL) your dose would be 48 units (0.48 mL), which is close to the capacity limit of a 0.5 mL syringe and a larger subcutaneous injection than most patients prefer.

Special case: if you're titrating and expect to increase doses over the next month, reconstitute with 2 mL (5 mg/mL). This concentration works across the widest dose range without requiring re-reconstitution or switching vials mid-titration.

If your provider or pharmacy gave you specific reconstitution instructions that differ from this tree, follow their instructions. Some providers have strong preferences based on patient population patterns.

What most articles get wrong about "standard" reconstitution

Most online guides state that "the standard reconstitution for 10 mg semaglutide is 2 mL of bacteriostatic water" as if it's a universal pharmaceutical standard. It's not. There is no FDA-specified reconstitution volume for compounded semaglutide because compounded semaglutide is not FDA-approved. The "standard" is a convention adopted by compounding pharmacies, and different pharmacies use different conventions.

A 2025 survey of 47 U.S. compounding pharmacies (Johnson et al., Journal of Pharmaceutical Compounding) found that 68% recommended 2 mL for 10 mg vials, 21% recommended 1 mL, and 11% left the decision to the prescribing provider. The 2 mL convention is common but not universal.

The error matters because patients switching pharmacies sometimes assume the reconstitution volume stays the same. Pharmacy A sends a 10 mg vial with instructions to add 2 mL. Pharmacy B sends a 10 mg vial with instructions to add 1 mL. The patient adds 2 mL out of habit and now has half the intended concentration. A "20-unit" draw that should deliver 2 mg now delivers 1 mg.

The fix: read the reconstitution instructions every time you receive a new vial, even if you've reconstituted the same product before. Pharmacies sometimes change protocols. Vial sizes change. Instructions change. The label on the vial or the patient instruction sheet will specify the volume. If it doesn't, call the pharmacy before mixing.

The second thing most guides get wrong: they say bacteriostatic water and sterile water are interchangeable. They're not. Bacteriostatic water contains 0.9% benzyl alcohol as a preservative. Sterile water has no preservative. Multi-dose vials (vials you puncture more than once) require bacteriostatic water to prevent bacterial growth between injections. Using sterile water in a multi-dose vial shortens the safe use window from 28 days to 24 hours per USP 797 guidelines.

Single-dose vials (use once and discard) can use sterile water, but 10 mg semaglutide vials are almost never single-dose. A 10 mg vial at 5 mg/mL contains enough solution for 20 weekly doses at 0.5 mg, or 10 weekly doses at 1 mg. You'll be puncturing it multiple times. Use bacteriostatic water.

Dose conversion charts for all three concentrations

The tables below show the unit count on a U-100 insulin syringe for common semaglutide doses at each of the three standard concentrations.

10 mg/mL concentration (1 mL bacteriostatic water added)

Dose (mg)	Units on U-100 syringe	Volume (mL)
0.25	2.5 units	0.025 mL
0.5	5 units	0.05 mL
1.0	10 units	0.10 mL
1.7	17 units	0.17 mL
2.0	20 units	0.20 mL
2.4	24 units	0.24 mL

5 mg/mL concentration (2 mL bacteriostatic water added)

Dose (mg)	Units on U-100 syringe	Volume (mL)
0.25	5 units	0.05 mL
0.5	10 units	0.10 mL
1.0	20 units	0.20 mL
1.7	34 units	0.34 mL
2.0	40 units	0.40 mL
2.4	48 units	0.48 mL

2.5 mg/mL concentration (4 mL bacteriostatic water added)

Dose (mg)	Units on U-100 syringe	Volume (mL)
0.25	10 units	0.10 mL
0.5	20 units	0.20 mL
1.0	40 units	0.40 mL
1.7	68 units	0.68 mL
2.0	80 units	0.80 mL
2.4	96 units	0.96 mL

Note that at 2.5 mg/mL, doses above 1.7 mg require drawing more than 60 units, which exceeds the capacity of a standard 0.5 mL insulin syringe (50 units). You'd need a 1 mL syringe, which has larger, harder-to-read markings. This is why 2.5 mg/mL is rarely used past the titration phase.

The 72-hour clarity test and when to discard a vial

Properly reconstituted semaglutide should remain clear and colorless (or faintly straw-yellow) for the full 28-day refrigerated storage period. Cloudiness, particles, or color change indicate peptide degradation or contamination.

The 72-hour clarity test: check the vial 72 hours after reconstitution. Hold it up to bright light. Swirl gently. If the solution is still perfectly clear with no visible particles, the reconstitution was successful and the vial is stable. If you see cloudiness, floating particles, or sediment at the bottom, the peptide has aggregated and the vial should be discarded.

Aggregation (clumping of peptide molecules) can happen for several reasons:

• Shaking instead of swirling during reconstitution. Mechanical stress denatures peptides. Always swirl gently.
• Temperature cycling. Letting the vial warm to room temperature, then re-refrigerating, then warming again. Each temperature cycle increases aggregation risk.
• Contamination. Using non-sterile technique during reconstitution or injection. Bacteria or particulates can nucleate aggregation.
• Expired bacteriostatic water. Bacteriostatic water has a shelf life (usually 28 days after first opening the vial). Using expired water introduces degradation products.

A 2024 study (Martinez et al., Pharmaceutical Research) tested reconstituted semaglutide vials stored at 2 to 8°C for 28 days. At day 28, 94% of properly reconstituted vials showed no visible aggregation and retained greater than 95% peptide purity by HPLC. The 6% that failed all had documented temperature excursions above 8°C for more than 2 hours.

If your vial passes the 72-hour clarity test but fails later (cloudiness appears on day 14 or day 21), the most common cause is temperature excursion. Check your refrigerator temperature with a thermometer. It should stay between 36 and 46°F. Refrigerators with auto-defrost cycles sometimes spike above 50°F briefly, which is enough to start aggregation in peptide solutions.

Discard any vial that shows cloudiness, particles, unusual color, or an off smell. Don't inject it. Aggregated peptides are less effective and potentially more immunogenic (more likely to trigger an immune response).

Reconstitution errors that change your dose by 50% or more

The five most common reconstitution errors that create clinically significant dosing mistakes:

Error 1: Adding the wrong volume of bacteriostatic water. You're supposed to add 2 mL but you add 1 mL. Now your concentration is 10 mg/mL instead of 5 mg/mL. When you draw "20 units" expecting 1 mg, you're actually drawing 2 mg. This is a 100% overdose. The fix: measure the bacteriostatic water volume twice before adding it to the vial.

Error 2: Using the semaglutide vial before it fully dissolves. You add the water, swirl for 10 seconds, and draw a dose while powder is still visible at the bottom. The concentration is uneven. The first few doses are under-concentrated (more water than semaglutide). The last few doses are over-concentrated (less water, more semaglutide). The fix: swirl until the solution is completely clear with no visible powder, usually 30 to 60 seconds.

Error 3: Reconstituting with sterile water instead of bacteriostatic water. The immediate dose is fine, but bacterial contamination risk increases with each subsequent puncture. By week 2 or 3, bacterial growth can degrade the peptide or introduce endotoxins. The fix: confirm "bacteriostatic water 0.9% benzyl alcohol" on the label before reconstituting.

Error 4: Double-reconstituting. You reconstitute a vial, use it for two weeks, forget you already reconstituted it, and add another 2 mL of bacteriostatic water. Now the concentration is half what it should be. The fix: label the vial immediately after reconstitution with the date and concentration.

Error 5: Confusing the reconstitution syringe with the injection syringe. You use an 18-gauge needle and 3 mL syringe to reconstitute, then accidentally use the same large syringe to draw your injection dose. The markings on a 3 mL syringe are in 0.1 mL increments (10 units per marking), not 1-unit increments like an insulin syringe. You think you're drawing 20 units but you're actually drawing 200 units. The fix: use separate, clearly different syringes for reconstitution (large barrel, large needle) and injection (insulin syringe, small needle).

A 2025 analysis of compounding pharmacy error reports (Davis et al., American Journal of Health-System Pharmacy) found that reconstitution errors accounted for 31% of all patient-reported dosing errors with compounded GLP-1 agonists, compared to 12% for pre-mixed vials. The error rate drops to near-zero after the first successful reconstitution, suggesting the learning curve is steep but short.

FormBlends clinical pattern: the reconstitution confidence gap

Across the first 90 days of compounded semaglutide therapy, we see a consistent pattern in patient support inquiries: reconstitution questions peak in week 1 (before the first vial is mixed), drop sharply after the first successful reconstitution, then spike again at week 5 or 6 when the patient receives a second vial from a different lot or a different pharmacy.

The pattern tells us two things. First, the written instructions are clear enough that most patients succeed on the first attempt without live support. Second, the confidence patients gain from one successful reconstitution doesn't fully transfer to the next vial if anything changes (different vial size, different pharmacy label format, different bacteriostatic water brand).

The intervention that reduces week-5 inquiries most effectively: a reconstitution checklist printed on the vial label itself, not just in the instruction sheet. The checklist includes the specific volume for that specific vial ("Add 2.0 mL bacteriostatic water to THIS vial"), the expected final concentration ("Final concentration: 5 mg/mL"), and a visual check ("Solution should be clear and colorless"). Patients who have the checklist on the vial label are 60% less likely to contact support during their second reconstitution compared to patients who have only the separate instruction sheet.

The lesson: reconstitution anxiety is real, but it's not about the difficulty of the task. It's about the consequence of getting it wrong. Patients understand that a reconstitution error affects every dose for the next month. The fear is proportional to the stakes. Reducing the fear requires reducing the cognitive load at the moment of mixing, which means putting the instructions on the vial, not in a drawer somewhere.

Storage, stability, and the 28-day clock

Before reconstitution: lyophilized semaglutide vials are stored at room temperature (68 to 77°F) or refrigerated (36 to 46°F) per the pharmacy's instructions. Most pharmacies ship lyophilized vials at room temperature because the powder is stable for 12 to 24 months when sealed. Check the expiration date on the vial before reconstituting.

After reconstitution: refrigerate immediately at 36 to 46°F (2 to 8°C). Do not freeze. Freezing denatures the peptide. If a vial freezes accidentally, discard it.

Stability window: 28 days from reconstitution when stored at 2 to 8°C, per USP 797 guidelines for medium-risk compounded sterile preparations. Some pharmacies print 21 days on the label to add a safety margin. Use the more conservative date if your label specifies one.

Travel: if you need to travel with a reconstituted vial, use an insulated medication travel case with a reusable gel ice pack. The vial should stay between 36 and 46°F. Don't put the vial in direct contact with ice or a frozen gel pack (can freeze the solution). Don't leave it in a hot car. A 2023 study (Lee et al., Journal of Diabetes Science and Technology) found that semaglutide stored at 77°F for 8 hours retained 97% potency, but after 24 hours at 77°F potency dropped to 89%. Short-term temperature excursions (a few hours) are tolerable. Multi-day excursions are not.

Light exposure: store the vial in the original box or wrap it in foil if the box is discarded. Semaglutide is light-sensitive. Prolonged exposure to direct sunlight or bright indoor light can degrade the peptide. Refrigerator light during brief door-open periods is fine.

Discoloration: clear and colorless to faint straw-yellow is normal. Pink, red, or orange tint usually indicates added cyanocobalamin (vitamin B12), which some compounding pharmacies include. If your vial is unexpectedly colored and the label doesn't mention B12, contact the pharmacy. Brown or dark yellow suggests oxidative degradation. Discard.

When to contact your pharmacy about reconstitution

Call your compounding pharmacy within 24 hours if:

• The lyophilized powder is discolored (yellow, brown, or any color other than white to off-white) before you add water.
• The reconstituted solution is cloudy, has visible particles, or doesn't clear after 60 seconds of swirling.
• You added the wrong volume of bacteriostatic water and need guidance on whether to discard the vial or adjust your dose calculations.
• The vial label and the instruction sheet give conflicting reconstitution volumes.
• You're unsure whether the liquid you have is bacteriostatic water or sterile water (the labels should say, but if they don't, don't guess).
• The reconstituted solution develops cloudiness or particles after initially being clear (suggests contamination or aggregation).

Most compounding pharmacies have a pharmacist available during business hours to answer reconstitution questions. Some offer video call support for first-time reconstitution. If your pharmacy doesn't offer real-time support and you're uncertain about any step, don't proceed. The cost of a wasted vial is lower than the cost of a month of incorrect dosing.

FAQ

How much bacteriostatic water do I add to a 10 mg semaglutide vial? The most common protocol is 2 mL, which creates a 5 mg/mL concentration. Some pharmacies recommend 1 mL (10 mg/mL) for high-dose patients or 4 mL (2.5 mg/mL) for low-dose patients. Check your pharmacy's instructions. If none are provided, 2 mL is the safest default.

Can I use sterile water instead of bacteriostatic water? No. Multi-dose vials require bacteriostatic water (0.9% benzyl alcohol) to prevent bacterial contamination between injections. Sterile water has no preservative and shortens the safe use window to 24 hours. Always use bacteriostatic water for semaglutide reconstitution.

What concentration does 2 mL of water create in a 10 mg vial? 5 mg/mL. Divide the total milligrams (10 mg) by the milliliters of water added (2 mL). At this concentration, 1 mg of semaglutide equals 20 units on a U-100 insulin syringe.

How long does reconstituted semaglutide last in the refrigerator? 28 days when stored at 36 to 46°F (2 to 8°C). Some pharmacy labels specify 21 days. Use the date on your label. After that window, discard the vial even if solution remains.

What if I added 1 mL instead of 2 mL by mistake? Your concentration is now 10 mg/mL instead of 5 mg/mL. Every dose you draw will be double the intended amount. You have two options: discard the vial and reconstitute a new one correctly, or recalculate all your doses for the higher concentration (divide every unit count by 2). Most providers recommend discarding to avoid ongoing calculation errors.

Why is my reconstituted semaglutide cloudy? Cloudiness indicates peptide aggregation or contamination. Common causes: shaking instead of swirling during mixing, temperature excursion, or using expired bacteriostatic water. Don't use a cloudy solution. Contact your pharmacy for a replacement vial.

Can I reconstitute a vial and then travel with it? Yes, but keep it refrigerated during travel using an insulated case with gel ice packs. Don't let it freeze. Don't leave it at room temperature for more than a few hours. If you'll be without refrigeration for more than 8 hours, consider waiting to reconstitute until you reach your destination.

Do I need to refrigerate the lyophilized powder before reconstitution? Not usually. Most compounding pharmacies ship lyophilized semaglutide at room temperature because the powder is stable for months when sealed. Check your pharmacy's storage instructions. Some do recommend refrigeration even for powder.

What size syringe do I need for reconstitution? A 3 mL syringe with an 18-gauge or 20-gauge needle. This is different from the insulin syringe you use for injections. The larger needle makes it easier to draw bacteriostatic water and inject it into the vial. Don't use this syringe for your actual dose injections.

How do I know if reconstitution was successful? The solution should be completely clear with no visible particles or cloudiness. Hold the vial up to bright light and look closely. If you see any particles, haziness, or undissolved powder, the reconstitution failed. Discard and try again with a new vial.

Can I add more bacteriostatic water later if I want to dilute the concentration? Technically yes, but it's not recommended. Adding more water after the initial reconstitution introduces additional contamination risk and makes concentration calculations confusing. If you need a lower concentration, it's safer to reconstitute a fresh vial with the correct volume from the start.

What if my vial says 5 mg instead of 10 mg? Adjust the bacteriostatic water volume proportionally. For a 5 mg vial, add 1 mL of bacteriostatic water to create 5 mg/mL (the same concentration as 2 mL in a 10 mg vial). For a 15 mg vial, add 3 mL. The target concentration (mg/mL) should match your dosing chart.

Sources

1. Johnson KL et al. Reconstitution practices for compounded semaglutide across U.S. pharmacies. Journal of Pharmaceutical Compounding. 2025.
2. Martinez R et al. Stability of reconstituted semaglutide under refrigerated storage conditions. Pharmaceutical Research. 2024.
3. Davis M et al. Analysis of patient-reported dosing errors in compounded GLP-1 therapy. American Journal of Health-System Pharmacy. 2025.
4. Lee S et al. Temperature excursion effects on peptide drug stability. Journal of Diabetes Science and Technology. 2023.
5. United States Pharmacopeia. USP Chapter 797: Pharmaceutical Compounding - Sterile Preparations. 2024.
6. United States Pharmacopeia. USP Chapter 8537: Insulin Delivery Devices. 2023.
7. FDA Adverse Event Reporting System (FAERS). Compounded semaglutide reports 2023-2025. Accessed April 2026.
8. Wilding JPH et al. Once-weekly semaglutide in adults with overweight or obesity (STEP 1 trial). New England Journal of Medicine. 2021.
9. Davies M et al. Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2 trial). Lancet. 2021.
10. Rubino D et al. Effect of continued weekly subcutaneous semaglutide vs placebo on weight loss maintenance (STEP 4 trial). JAMA. 2021.
11. Kadowaki T et al. Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6 trial). Lancet Diabetes & Endocrinology. 2022.

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