Niacinamide does not change your tirzepatide dose, so there is no separate chart for it. Niacinamide is a form of vitamin B3. Some compounding pharmacies add it to their tirzepatide vials. Your tirzepatide dose still follows the label: 2.5 to 15 mg once a week. Your syringe units still depend only on the tirzepatide mg/mL on the vial. No trial has tested the two together. If you are new to the drug, start with our tirzepatide guide.
Key takeaways
- Zepbound and Mounjaro contain tirzepatide only. Their labels do not mention niacinamide.
- Niacinamide in a compounded vial is an added ingredient. The tirzepatide mg and unit math are the same as any other vial at the same concentration.
- The SURMOUNT and SURPASS trials tested tirzepatide alone. There is no trial evidence for adding niacinamide, and this page makes no dose claims for it.
- The tirzepatide schedule is unchanged: 2.5 mg once weekly for 4 weeks, then 2.5 mg steps after at least 4 weeks each, up to 15 mg.
- Compounded tirzepatide, with or without niacinamide, is not FDA approved and is not interchangeable with Zepbound or Mounjaro.
What is tirzepatide with niacinamide?
Niacinamide, also called nicotinamide, is a form of vitamin B3. It is not a GLP-1 drug and it is not tirzepatide. Some compounding pharmacies add it to their tirzepatide vials, and the product then appears on the label as "tirzepatide/niacinamide" with two concentrations listed.
Pharmacies give various reasons for the addition. None of those reasons come from the tirzepatide label, and none have been tested in a published tirzepatide trial in the Sources below. So the honest position is this: the tirzepatide in the vial is what the trials studied, and the niacinamide is an add-in with no tirzepatide-specific evidence behind it.
Does niacinamide change the tirzepatide dosing math?
No. Your prescriber writes a tirzepatide dose in mg. You convert that to units using the tirzepatide concentration in mg/mL. The niacinamide concentration on the same label is a separate number and does not enter the calculation. This table uses 10 mg/mL of tirzepatide as the example.
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Start Free Assessment →| Tirzepatide dose | Volume at 10 mg/mL | Units on a U-100 syringe |
|---|---|---|
| 2.5 mg | 0.25 mL | 25 units |
| 5 mg | 0.5 mL | 50 units |
| 7.5 mg | 0.75 mL | 75 units |
| 10 mg | 1.0 mL | 100 units |
| 12.5 mg | 1.25 mL | 125 units |
| 15 mg | 1.5 mL | 150 units |
Source: arithmetic from the labeled strengths (Zepbound and Mounjaro prescribing information) and the U-100 standard (1 mL = 100 units). The tirzepatide concentration on your vial controls; niacinamide is not part of the math.
If your vial is 5 mg/mL of tirzepatide, double the units. If it is 20 mg/mL, halve them. The full chart at every concentration is on the tirzepatide dosage chart. Whatever volume you draw, you get the niacinamide that comes with it; you cannot dose the two separately from one vial.
Empower tirzepatide dosing chart
Searches for "Empower tirzepatide dosing" usually refer to a compounding pharmacy whose tirzepatide vials include niacinamide. The dosing is not different from any other compounded tirzepatide. Your prescriber sets the tirzepatide mg, following the same schedule as the brand label, and the tirzepatide concentration on that pharmacy's label sets the units. We do not publish another pharmacy's concentrations or prices here, because they change and only that pharmacy's label is authoritative for its vial.
| Weeks on treatment | Tirzepatide dose (label schedule) | Does niacinamide change this? |
|---|---|---|
| 1 to 4 | 2.5 mg once weekly | No |
| 5 to 8 | 5 mg once weekly | No |
| 9 to 12 | 7.5 mg once weekly | No |
| 13 to 16 | 10 mg once weekly | No |
| 17 to 20 | 12.5 mg once weekly | No |
| 21 onward | 15 mg once weekly (maximum) | No |
Source: Zepbound and Mounjaro prescribing information, Dosage and Administration. Weeks assume the earliest allowed step-up; prescribers often go slower.
What the tirzepatide label says about niacinamide
Nothing. The Zepbound and Mounjaro prescribing information list tirzepatide as the only active ingredient. The labels' dosing, missed-dose rules (take within 4 days, otherwise skip; never two doses within 3 days), storage, warnings and drug interactions were all written for tirzepatide alone. When a page tells you a "tirzepatide niacinamide" dose limit, ask where it came from. It did not come from the label.
What the trials say
The trials behind tirzepatide's approvals used tirzepatide alone. SURMOUNT-1 enrolled 2,539 adults with obesity or overweight and reported average weight loss of 15.0%, 19.5% and 20.9% at 5, 10 and 15 mg over 72 weeks, versus 3.1% on placebo. SURPASS-2 compared tirzepatide with semaglutide in type 2 diabetes. None of these trials added niacinamide, so none can tell you whether the add-in helps, hurts or does nothing for weight loss, nausea or anything else. That is not a criticism of pharmacies; it is simply the state of the evidence.
Safety points that still apply
Every warning on the tirzepatide label applies to a niacinamide combination vial, because the tirzepatide is unchanged. That includes the boxed warning for thyroid C-cell tumors, the contraindication for people with a personal or family history of medullary thyroid carcinoma or MEN 2, and the warnings for pancreatitis, gallbladder disease, kidney injury from dehydration, and low blood sugar with insulin or sulfonylureas. The label also lists hypersensitivity reactions. If you develop flushing, itching or a rash after switching to a combination vial, tell your prescriber. Whether the reaction is to tirzepatide, the add-in, or something else is a clinical call, not a chart lookup.
What this means for compounded tirzepatide
A compounded vial, with or without niacinamide, is not FDA approved and is not interchangeable with Zepbound or Mounjaro. Read the vial label for every ingredient and both concentrations. If you have a choice, ask your prescriber whether a tirzepatide-only formulation is available and whether there is any reason to choose one over the other for you.
At FormBlends, compounded tirzepatide is $149 for the first month, then $239 a month, or $214 a month with Subscribe & Save, with the same price at every dose. Prescriptions are written by independent, state-licensed clinicians of Recess MD LLC, and medication is compounded by state-licensed 503A compounding pharmacies. See pricing or begin at start. Our guide to compounded tirzepatide for weight loss explains how the process works.
Frequently Asked Questions
What is tirzepatide niacinamide?
It is compounded tirzepatide with niacinamide, a form of vitamin B3, mixed into the same vial. The tirzepatide is the active weight-management drug. The niacinamide is an added ingredient that is not on the Zepbound or Mounjaro label and has not been studied with tirzepatide in a published trial.
Is there an Empower tirzepatide dosing chart?
The dosing for any compounded tirzepatide, including pharmacies that add niacinamide, follows your prescriber's schedule, which usually mirrors the label: 2.5 mg weekly for 4 weeks, then 2.5 mg steps. The units you draw depend on the tirzepatide concentration on that pharmacy's label, so use their number.
Does niacinamide change how many units I draw?
No. Units come from the tirzepatide dose divided by the tirzepatide concentration, times 100. At 10 mg/mL, 5 mg is 50 units whether or not niacinamide is in the vial.
How much niacinamide is in the vial and is that dose safe?
The amount varies by pharmacy and is printed on the label. This page does not give a niacinamide dose or a safety limit, because no tirzepatide trial or label supplies one. Ask the pharmacist who filled the vial and your prescriber.
Can I take tirzepatide with vitamin B12 instead?
Some pharmacies use B12 as the add-in rather than niacinamide. The same logic applies: it does not change the tirzepatide math and has no tirzepatide trial evidence. See can you take B12 with tirzepatide.
Sources
- Zepbound (tirzepatide) prescribing information, Eli Lilly via DailyMed, revised 08/2026.
- Mounjaro (tirzepatide) prescribing information, Eli Lilly via DailyMed, revised 08/2026.
- Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1), Jastreboff et al., New England Journal of Medicine, 2022.
- Compounding and the FDA: Questions and Answers, U.S. Food and Drug Administration.
- FDA's Concerns with Unapproved GLP-1 Drugs Used for Weight Loss, U.S. Food and Drug Administration.
- FormBlends pricing, Form Blends LLC, verified September 5, 2026.
Next steps
Use the tirzepatide dosage chart for units at every concentration and read is compounded tirzepatide safe before choosing a pharmacy. Browse the tirzepatide hub for every other tirzepatide question. Talk to a clinician about any add-in before you inject. Compounded tirzepatide is not FDA approved and is not interchangeable with Zepbound or Mounjaro; a licensed provider decides whether it is appropriate for you.
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