Low Dose Naltrexone

Naltrexone at its standard 50 mg dose is an opioid receptor antagonist used in dependence treatment. Low dose naltrexone uses roughly a tenth of that, typically 1.5 to 4.5 mg. At this level, research has examined a distinct effect: a brief, transient blockade of opioid receptors that is thought to prompt a rebound increase in the body's own endorphins and to modulate glial and inflammatory signaling. That mechanism is why LDN appears in off-label protocols for inflammatory and autoimmune conditions, chronic pain, and general wellbeing. The evidence base is emerging rather than established, and use at these doses is off-label. A licensed provider reviews your full medication list, since LDN is not taken alongside opioids, and starts low with titration. Compounded to precise doses by a US-licensed pharmacy.