Metformin ER

Metformin is among the most prescribed and best-characterized medications in medicine, with decades of safety data from its use in type 2 diabetes. It works mainly by reducing the amount of glucose the liver produces and by improving the body's sensitivity to insulin, effects linked partly to activation of AMPK, a cellular energy sensor. Those metabolic effects, along with epidemiology suggesting broader benefits, are why metformin appears in longevity protocols and is the subject of the TAME human trial. Its use outside diabetes is off-label. The extended-release formulation smooths absorption and is easier on the stomach than immediate-release. A licensed provider reviews your history, including kidney function, and B12 is monitored with long-term use; dispensed by a US-licensed pharmacy.