Rapamycin

Rapamycin, generically sirolimus, is one of the most-studied molecules in longevity science. It inhibits mTOR (the mechanistic target of rapamycin), a central signaling pathway that senses nutrients and governs the balance between cell growth and cellular maintenance processes such as autophagy. In animal models across species, intermittent mTOR inhibition has extended lifespan and healthspan, which is why it anchors many longevity protocols. It is FDA-approved for transplant rejection and certain conditions, and its use for longevity is off-label, typically on a weekly rather than daily schedule to favor the maintenance effect while limiting immune suppression. Human longevity trials are ongoing. A licensed provider reviews your history, screens for active infection and interacting medications, and sets the protocol; compounded by a US-licensed pharmacy. It is not appropriate for everyone.