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Auto-generated transcript of @nursedoza's video. Quoted here for educational fact-check commentary; original creator retains all rights to the video content.
- 0:00So if you get a nad injection or a nad IV, it's very possible that you could feel a very big euphoric
- 0:06feeling afterwards within minutes, maybe even sometimes during the IV. This is not going to be
- 0:11felt if you take oral nad pills. And I'm telling this because there's a big difference.
- 0:17NAD is trending right now in AD plus, right? There's a big reason why it's trending is because it
- 0:22helps a lot of people with energy, with cognition, with recovery. That's how we promote in the
- 0:26clinic. Now we've done nad injections and IVs for years. We've given it for people as a way to
- 0:32help them with longevity, with function, with anything they need. If you take nad pills, which I have before,
- 0:39you don't feel the same after injection. That euphoric feeling, you know that it's actually working.
- 0:44Okay, now it's not going to feel like this for about an hour or two afterwards. I mean,
- 0:49this is only for a brief moment, initially after the nad being introduced into your body with the
- 0:54injections, right? And I've experienced this. I felt it full body. It is a very interesting
- 0:59sensation. I am not going to lie. And a lot of times I have to warn people because it is so
- 1:04different than what you're used to. However, the benefits that you get long term from the nad
- 1:10injections and the nad IVs are monumental. I have personally done them every week for the last six
- 1:17years. I have clients that have done it personally for the last six years. And they say it's a game
- 1:23changer, a non-negotiable, if you will. And if you think about, if you look at supplements
- 1:28going long term, we always want to promote anti-aging and longevity and we want to live forever and
- 1:32feel great doing it, right? Well, what are you taking right now that's going to make you feel good
- 1:36when you're 100 or 90 or 85? I know that nad is going to be my arsenal from here on out.
NAD+ injections and euphoria: what the evidence actually shows
Quick answer
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in cellular energy metabolism and DNA repair, with plasma levels declining measurably with age. IV and injectable NAD+ bypass first-pass metabolism and oral conversion pathways, producing faster systemic concentration changes than oral precursors like NMN or NR, though whether this translates to superior clinical outcomes in humans has not been established in adequately powered trials. The acute sensory effects described in the video, including flushing, warmth, and mood shifts, are commonly reported during rapid NAD+ infusions and are generally attributed to infusion rate and vasodilatory effects rather than confirmed NAD+ cellular uptake.
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This page currently connects to 7 source-backed evidence items through visible references or structured citation data.
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For NAD+ injections and euphoria: what the evidence actually shows, FormBlends checks the page topic against primary trials, systematic reviews, guidelines, and current PubMed-indexed literature where available. These citations are context, not medical advice, proof of eligibility, or a claim that every study applies to every patient.
NAD+ metabolism and its roles in cellular processes during ageing
Core review for NAD+ decline, mitochondrial function, DNA repair, and aging biology.
PubMed
Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women
Human NMN source for metabolic claims while keeping population limits clear.
PubMed
Emerging pharmacotherapies for obesity: A systematic review
Broad context for new and established obesity-drug categories.
PubMed
Glucagon-like receptor agonists and next-generation incretin-based medications
Current review for incretin-based obesity medications and cardiometabolic effects.
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Keep researching this nad+ video claims cluster
Best for searchers separating NAD+ longevity marketing from practical metabolic and safety questions.
Page-specific review note
What this exact clip is really saying
This FormBlends review is specific to "NAD+ injections and euphoria: what the evidence actually shows" from Nurse Doza. We read the clip as a Peptide social video fact-checks claim about NAD+ Peptide Complex, then separate the useful signal from what a short social video cannot prove. The page-specific claim focus is: NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in cellular energy metabolism and DNA repair, with plasma levels declining measurably with age.
The reason this review is not generic is the source wording and the canonical claim label "peptides replying to lauren s gardner nad injections and feeling euph." In this clip, the useful excerpt is: "So if you get a nad injection or a nad IV, it's very possible that you could feel a very big euphoric feeling afterwards within minutes, maybe even sometimes during the IV." That wording changes the review because it points to NAD+ Peptide Complex safety, access, evidence, and fit, not a one-size-fits-all protocol.
The source trail for this page is checked against NAD+ metabolism and its roles in cellular processes during ageing (2021), Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women (2021), and Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults (2018), plus the creator's own wording. NAD+ Peptide Complex still needs an eligibility review, medication-interaction screen, access check, and quality-control review before anyone treats a social clip as medical advice.
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Claim being checked
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in cellular energy metabolism and DNA repair, with plasma levels declining measurably with age.
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NAD+ Peptide Complex safety, access, evidence, and fit
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Source-backed review with clinical or regulatory citations.
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Compare the claim with the NAD+ Peptide Complex guide, safety notes, access rules, and a licensed-provider review.
What to do with this video
Use the clip as a claim to verify, not a treatment plan
What it helps with
- NAD+ (nicotinamide adenine dinucleotide) is a coenzyme involved in cellular energy metabolism and DNA repair, with plasma levels declining measurably with age. IV and injectable NAD+ bypass first-pass metabolism and oral conversion pathways, producing faster systemic concentration changes than oral precursors like NMN or NR, though whether this translates to superior clinical outcomes in humans has not been established in adequately powered trials. The acute sensory effects described in the video, including flushing, warmth, and mood shifts, are commonly reported during rapid NAD+ infusions and are generally attributed to infusion rate and vasodilatory effects rather than confirmed NAD+ cellular uptake.
- NAD+ levels decline with age and preclinical animal studies show metabolic benefits from restoring them, but human longevity data from controlled trials is still limited (Rajman et al., 2018, Cell Metabolism).
- IV NAD+ does reach systemic circulation faster than oral precursors, making the bioavailability distinction in the video pharmacologically reasonable, though superiority in human outcomes is not proven.
What it may miss
- It may not cover eligibility, contraindications, medication interactions, lab history, or dose escalation.
- NAD+ Peptide Complex decisions still need source quality, legal access, and provider oversight checks.
- Social video captions rarely show the full evidence base behind a claim.
Best next step
Compare the claim against the NAD+ Peptide Complex guide, cost path, safety notes, and provider review before acting.
Review NAD+ Peptide ComplexWhat You'll Learn
- NAD+ levels decline with age and preclinical animal studies show metabolic benefits from restoring them, but human longevity data from controlled trials is still limited (Rajman et al., 2018, Cell Metabolism).
- IV NAD+ does reach systemic circulation faster than oral precursors, making the bioavailability distinction in the video pharmacologically reasonable, though superiority in human outcomes is not proven.
- The acute 'euphoric' sensation during NAD+ infusions is commonly reported but is associated with infusion rate and vasodilation, not confirmed evidence that cellular replenishment is occurring.
- Oral NMN supplementation was shown to raise blood NAD+ levels in a 2023 Nature Aging RCT by Liao et al., suggesting oral delivery is not ineffective, only slower in its pharmacokinetics.
- No peer-reviewed human trial has followed patients for six years of weekly NAD+ injections to assess long-term outcomes, so claims of 'monumental' benefits rest on anecdote, not data.
- Injection-based NAD+ therapy carries real clinical risks including infection at injection sites and adverse infusion reactions that any honest discussion of the therapy should include.
- The FDA has not approved NAD+ injections for any specific indication, and compounded NAD+ preparations vary in formulation and quality, a fact absent from the video's framing.
Our take · Written by FormBlends editorial team · Reviewed by FormBlends Medical Team · This is not a transcript. It is our independent review of the video above.
What did @nursedoza actually say?
The claim is that NAD injections and IVs produce a rapid "euphoric feeling" that proves the treatment is working, that this effect is absent from oral NAD supplements, and that long-term weekly injections deliver "monumental" benefits for longevity and function. She also said she has personally injected NAD every week for six years and that she warns clients about the sensation because it is so intense.
The video is promotional in tone. Phrases like "we always want to promote anti-aging" and references to her clinic make clear this is not a neutral educational post. That does not automatically make the claims false, but it is worth noting before treating this as disinterested medical information.
Does the science back this up?
Partially, and the honest answer is: the research is promising but nowhere near as settled as the video implies. NAD+ is a legitimate area of active scientific inquiry, but the leap from lab findings to "monumental" human longevity benefits is a large one that the current evidence does not fully support.
NAD+ levels do decline with age, and preclinical research in animals has shown that restoring NAD+ levels improves metabolic function and extends healthspan in some models (Rajman, Chwalek, and Bhatt, 2018, Cell Metabolism). Human trials exist but are mostly small and short-term. A 2023 randomized controlled trial by Liao et al. in Nature Aging showed that NMN supplementation raised blood NAD+ levels in older adults, but functional outcomes like energy or cognition were modest. IV delivery does produce faster NAD+ uptake than oral routes, which has some pharmacological basis, but "euphoric" effects specifically have not been characterized in published clinical literature in any rigorous way.
What did they get wrong (or right)?
Credit where it is due: the distinction between oral and injectable NAD+ bioavailability is real. Oral NAD+ precursors like NMN and NR are converted through metabolic pathways before raising tissue NAD+ levels, while IV administration bypasses that process. The claim that you would feel a difference is at least plausible pharmacologically.
Where the video goes wrong is in treating the euphoric sensation as proof that the treatment "is actually working." That is not how pharmacology works. Flushing, tingling, and mood shifts during IV infusions can result from rapid osmotic changes, vasodilation, or simply the infusion rate, none of which confirm cellular NAD+ replenishment is occurring. The video also uses personal testimony and client anecdotes as stand-ins for outcome data. Six years of weekly injections is not a clinical study. "Game changer" and "non-negotiable" are marketing phrases, not medical assessments. The claim that NAD injections will make you "feel good when you're 100" has no controlled evidence behind it in humans.
What should you actually know?
NAD+ therapy is an area where the science is genuinely interesting and the clinical evidence is genuinely thin. Those two facts can coexist. If you are considering NAD+ IV or injection therapy, here is what the research actually supports versus what remains speculative.
- NAD+ precursors (NR and NMN) do raise blood NAD+ levels in humans (Elhassan et al., 2019, Cell Reports Medicine).
- IV NAD+ produces faster systemic delivery than oral precursors, but whether that translates to better tissue-level outcomes in humans is not established in large trials.
- The flushing and sensation during infusion is well-documented clinically and is linked to infusion rate, not confirmed therapeutic effect.
- No large randomized controlled trial has demonstrated that regular NAD+ injections extend human lifespan or prevent age-related disease.
- NAD+ therapy carries real costs and real administration risks, including infection risk at injection sites. These were not mentioned in the video.
The video is not dangerous misinformation, but it presents early-stage science as settled fact, which is a meaningful distinction for anyone making a financial or medical decision based on it.
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About the Creator
Nurse Doza · TikTok creator
123.1K views on this video
Replying to @Lauren S. Gardner NAD injections and feeling euphoric #NAD #nadplus #nadiv #nadinjection
Frequently asked questions
Quick answers based on this video and our medical team review.
What does the video say about nad+ levels decline with age?
NAD+ levels decline with age and preclinical animal studies show metabolic benefits from restoring them, but human longevity data from controlled trials is still limited (Rajman et al., 2018, Cell Metabolism).
What does the video say about iv nad+ does reach systemic circulation faster than?
IV NAD+ does reach systemic circulation faster than oral precursors, making the bioavailability distinction in the video pharmacologically reasonable, though superiority in human outcomes is not proven.
What does the video say about the acute 'euphoric' sensation during nad+ infusions?
The acute 'euphoric' sensation during NAD+ infusions is commonly reported but is associated with infusion rate and vasodilation, not confirmed evidence that cellular replenishment is occurring.
What does the video say about oral nmn supplementation was shown to raise blood nad+ levels?
Oral NMN supplementation was shown to raise blood NAD+ levels in a 2023 Nature Aging RCT by Liao et al., suggesting oral delivery is not ineffective, only slower in its pharmacokinetics.
What does the video say about no peer-reviewed human trial has followed patients for six years?
No peer-reviewed human trial has followed patients for six years of weekly NAD+ injections to assess long-term outcomes, so claims of 'monumental' benefits rest on anecdote, not data.
What does the video say about injection-based nad+ therapy carries real clinical risks including infection at?
Injection-based NAD+ therapy carries real clinical risks including infection at injection sites and adverse infusion reactions that any honest discussion of the therapy should include.
Sources & references
Citations extracted from our medical team's review. Click any citation to search PubMed.
Read More on This Topic
Our written guides go deeper with dosing details, comparison tables, and medical-team reviewed protocols.
Not medical advice. This video was made by Nurse Doza, not by FormBlends. Our write-up above is an editorial review, not a medical recommendation. Talk to your doctor before making any decisions about medications or treatments.