Melanotan II

Melanotan II (MT-II) is a cyclic heptapeptide analog of alpha-melanocyte stimulating hormone (alpha-MSH), originally developed at the University of Arizona. It activates melanocortin receptors (primarily MC1R) in melanocytes, stimulating the production and dispersion of melanin.

By activating the melanogenesis pathway directly, Melanotan II produces skin darkening similar to a natural tan without requiring UV exposure. This is significant because UV radiation is the primary environmental cause of skin aging and skin cancer.

Research has shown that the eumelanin produced in response to MC1R activation provides genuine photoprotection, absorbing UV radiation and scavenging free radicals. Individuals with fair skin (Fitzpatrick Type I-II) who have difficulty tanning naturally may achieve meaningful pigmentation through MT-II.

Melanotan II also activates MC3R and MC4R receptors, which are involved in appetite regulation, energy homeostasis, and sexual arousal pathways.