Key Takeaway
Detailed dosage guide for the GHK-Cu and BPC-157 skin repair stack. Covers injectable and topical doses, application-specific dosing, reconstitution calculator, and how to adjust for your skin goals.
Injectable GHK-Cu is typically dosed at 200 to 500 mcg per day subcutaneously, while BPC-157 is dosed at 250 to 500 mcg per day, with both peptides used alongside topical GHK-Cu applied once or twice daily. Dosing varies by treatment phase, specific skin concern, and whether you're using injectable, topical, or combined administration routes.
GHK-Cu Dosage: Injectable
Subcutaneous Injection
- Starting dose: 200 mcg per injection
- Standard therapeutic dose: 200-500 mcg per injection
- High dose: 500-1000 mcg per injection (used in some aggressive skin repair protocols)
Frequency by Phase
- Intensive phase (weeks 1-4): Once daily
- Improvement phase (weeks 5-8): 3-5 times per week
- Maintenance phase (ongoing): 2-3 times per week
Injection Site Selection
For general skin rejuvenation, inject subcutaneously in the abdomen. For localized concerns (facial aging, specific scars), some practitioners inject near the target area. GHK-Cu has systemic effects, so abdominal injection benefits skin throughout the body.
GHK-Cu Dosage: Topical
Serum or Cream Application
- Concentration: 0.01% to 1% GHK-Cu in serum or cream form
- Application: Apply a thin layer to clean, dry skin
- Frequency: Once or twice daily (AM and/or PM)
- Target areas: Face, neck, decolletage, hands, or any area of concern
Topical GHK-Cu doesn't require cycling and can be used continuously as part of a daily skincare routine.
View data table
| Category | Clinical Interest Score | Detail |
|---|---|---|
| BPC-157 | 88 | Tissue repair and gut healing |
| TB-500 | 82 | Injury recovery |
| Sermorelin | 78 | Growth hormone support |
| Ipamorelin | 75 | Anti-aging and recovery |
| GHK-Cu | 70 | Skin and tissue repair |
Post-Microneedling Application
When used immediately after microneedling, GHK-Cu serum penetrates deeper through the micro-channels. Apply liberally to the treated area immediately post-procedure and continue twice-daily application during the healing period. Some practitioners use GHK-Cu as the "glide serum" during the microneedling procedure itself.
BPC-157 Dosage for Skin Applications
Subcutaneous Injection
- Standard dose: 250-500 mcg per injection
- Frequency (intensive): Once or twice daily
- Frequency (maintenance): Once daily or 3-5 times per week
Injection Placement for Skin Goals
- General skin rejuvenation: Abdomen (systemic distribution)
- Specific scar treatment: Near the scar site
- Wound healing: Near the wound perimeter (not into the wound)
- Post-surgical skin repair: Near the incision site
BPC-157's effects are strongest locally, so injection near the target area is preferred for localized concerns. For whole-body skin improvement, abdominal injection is practical and effective. BPC-157 injection placement
Check your GLP-1 eligibility
Use our free BMI Calculator to see if you may qualify for provider-reviewed GLP-1 therapy.
Try the BMI Calculator →Combined Dosing Schedules by Goal
Anti-Aging and General Rejuvenation
| Component | Dose | Route | Frequency |
|---|---|---|---|
| GHK-Cu | 200-300 mcg | Subcutaneous | Daily (4 weeks), then 3x/week |
| BPC-157 | 250 mcg | Subcutaneous | Daily (4 weeks), then 3x/week |
| GHK-Cu serum | Per product | Topical | Twice daily, ongoing |
Scar Reduction
| Component | Dose | Route | Frequency |
|---|---|---|---|
| GHK-Cu | 300-500 mcg | Subcutaneous (near scar) | Daily for 6-8 weeks |
| BPC-157 | 500 mcg | Subcutaneous (near scar) | Daily for 6-8 weeks |
| GHK-Cu cream | Per product | Topical (on scar) | Twice daily |
Wound Healing
| Component | Dose | Route | Frequency |
|---|---|---|---|
| BPC-157 | 500 mcg | Subcutaneous (near wound) | Twice daily until closure, then once daily |
| GHK-Cu | 300-500 mcg | Subcutaneous | Once daily |
| GHK-Cu | Per product | Topical (wound margins after closure begins) | Once daily |
Post-Procedure Recovery
| Component | Dose | Route | Frequency |
|---|---|---|---|
| BPC-157 | 250-500 mcg | Subcutaneous | Daily, starting 3-5 days pre-procedure through 2 weeks post |
| GHK-Cu | 200-300 mcg | Subcutaneous | Daily during recovery period |
| GHK-Cu serum | Per product | Topical | Resume 24-72 hours post-procedure, twice daily |
Reconstitution and Volume Calculations
GHK-Cu
GHK-Cu typically comes in 5 mg or 10 mg vials. For a 5 mg vial reconstituted with 2 mL of bacteriostatic water:
- Concentration = 2.5 mg/mL (2500 mcg/mL)
- 200 mcg = 0.08 mL (8 units on an insulin syringe)
- 300 mcg = 0.12 mL (12 units)
- 500 mcg = 0.2 mL (20 units)
- One 5 mg vial provides 25 doses at 200 mcg or 10 doses at 500 mcg
BPC-157
BPC-157 commonly comes in 5 mg vials. Reconstituted with 2 mL of bacteriostatic water:
- Concentration = 2.5 mg/mL (2500 mcg/mL)
- 250 mcg = 0.1 mL (10 units)
- 500 mcg = 0.2 mL (20 units)
- One 5 mg vial provides 20 doses at 250 mcg or 10 doses at 500 mcg
Peptide reconstitution calculator
Storage
- Store reconstituted vials in the refrigerator (36-46 degrees F / 2-8 degrees C)
- Don't freeze reconstituted peptides
- Use reconstituted peptides within 3-4 weeks
- Unreconstituted powder can be stored at room temperature short-term or frozen for long-term storage
- Topical GHK-Cu products: follow manufacturer storage instructions (usually room temperature, away from direct sunlight)
Dose Adjustment Guidelines
When to Consider a Higher Dose
- Minimal visible improvement after 4-6 weeks at standard doses
- Severe skin damage, deep scarring, or significant photoaging
- Larger body size (over 200 lbs)
- Good tolerance with no side effects at current dose
When to Consider a Lower Dose
- Any skin irritation or sensitivity (uncommon but possible)
- Smaller body size (under 130 lbs)
- During maintenance phase when goals are being met
- Budget constraints requiring longer treatment duration at lower cost
Cost at Different Dose Levels
Monthly cost estimates for injectable protocols:
- Conservative maintenance: $75-150/month Contact provider for current pricing Contact provider for current pricing
- Standard intensive: $150-300/month
- Aggressive scar/wound protocol: $250-400/month
Topical GHK-Cu products add $30-100/month depending on concentration and brand. Contact provider for current pricing peptide therapy costs
Frequently Asked Questions
- What is the minimum effective dose of GHK-Cu for skin benefits?
-
For injectable GHK-Cu, 200 mcg per injection administered 2-3 times per week is generally considered the minimum effective dose for visible skin benefits. Topically, concentrations as low as 0.01% have shown measurable effects on collagen production in studies, though higher concentrations (up to 1%) may produce faster results.
- Should I use higher doses for deeper wrinkles?
-
Deeper wrinkles may benefit from higher GHK-Cu doses (400-500 mcg) and longer treatment duration rather than just standard doses. But consistency and duration of use typically matter more than dose intensity. A standard dose used consistently over 3-6 months often outperforms a high dose used inconsistently.
- Can I use topical GHK-Cu alone without injections?
-
Yes. Topical GHK-Cu alone provides meaningful skin benefits and is the most accessible form of copper peptide therapy. It's effective for surface-level improvements in skin texture, firmness, and tone. Adding injectable GHK-Cu and BPC-157 provides deeper, systemic support that amplifies topical results. topical peptide skincare
- How do I calculate my dose from a reconstituted vial?
-
Divide the total peptide amount by the volume of water used to reconstitute. For example: 5 mg peptide in 2 mL water = 2.5 mg/mL = 2500 mcg/mL. For a 250 mcg dose, draw 0.1 mL (10 units on a standard 100-unit insulin syringe). For a 500 mcg dose, draw 0.2 mL (20 units). peptide dosing calculator