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Intelligence Hub

Compound Intelligence Hub

76+ GLP-1, peptide, and HRT compounds in one place. Evidence-graded. Physician-reviewed.

Last reviewed: April 2026

Compound intelligence map showing mechanisms, clinical phase, evidence grade, and comparison links for GLP-1 and peptide compounds
A compound intelligence map that connects mechanisms, trial phases, evidence grades, and comparison pages.

61

Compounds Tracked

29

FDA Approved

32

Compounding Legal

181

Evidence Sources Cited

Showing all 61 compounds

Weight LossStrongFDA Approved

Semaglutide

Ozempic / Wegovy / Rybelsus

The GLP-1 receptor agonist that transformed weight loss medicine with proven cardiovascular benefits

14.9% mean weight loss at 68 wee...20% reduction in major adverse c...26% MACE reduction in type 2 dia...
$129-349/month depending on source and doseFull profile
Weight LossStrongFDA Approved

Tirzepatide

Mounjaro / Zepbound

Dual GLP-1/GIP agonist that outperforms semaglutide for weight loss in head-to-head trials

22.5% weight loss at 72 weeks (S...47% more weight loss than semagl...57% of participants on 15 mg ach...
$25-1,086/month depending on insurance, savings cards, and sourceFull profile
HRTStrongFDA Approved

HCG

Human Chorionic Gonadotropin

LH-mimicking hormone that preserves testicular function and fertility during TRT

Prevents testicular atrophy duri...Maintains intratesticular testos...Preserves fertility in men on ex...
$60-200/month depending on source and dosageFull profile
RecoveryModerateCompounding Legal

BPC-157

Body Protection Compound-157

Gut-derived healing peptide that accelerates tissue repair and reduces inflammation

Accelerates healing of tendons, ...Supports gut lining repair and r...Promotes new blood vessel format...
$100-250/month depending on dosage and providerFull profile
Sexual WellnessEmergingFDA Approved

Oxytocin

Pitocin (IV form), OT

Neuropeptide that influences bonding, sexual function, and stress response

May enhance orgasm intensity in ...Reduces social anxiety and impro...Modulates stress response throug...
$40-100/monthFull profile
Growth HormoneModerateCompounding Legal

Sermorelin

Sermorelin Acetate

Growth hormone releasing peptide that restores natural GH production safely

Increases natural growth hormone...Improves sleep quality and depth...Supports lean muscle mass develo...
$150-350/month depending on dose and providerFull profile
HRTStrongFDA Approved

Testosterone Enanthate

Test E, Delatestryl

Long-acting testosterone ester for hormone replacement and hypogonadism treatment

Restores testosterone levels in ...Improves lean body mass and redu...Increases bone mineral density o...
$30-80/monthFull profile
Weight LossStrongFDA Approved

Retatrutide

LY3437943

Triple agonist targeting GLP-1, GIP, and glucagon receptors for the deepest weight loss in clinical trials

Achieved 24.2% mean weight loss ...28.7% mean weight loss at 68 wee...Reduces liver fat by up to 82.4%...
$200-650/month from research suppliers (not legal for human use outside trials). Projected commercial price post-approval: $1,000-1,500/month based on tirzepatide/semaglutide pricingFull profile
ImmuneModerateCompounding Legal

Glutathione

GSH / L-Glutathione / Gamma-Glutamylcysteinylglycine

The body's master antioxidant, available as IV, injection, liposomal, and oral supplement forms

Central hub of the cellular anti...Liposomal form raised whole bloo...Essential for Phase II detoxific...
$20-80/month (oral/liposomal); $100-200/month (SC); $200-900/month (IV)Full profile
HRTModerateFDA Approved

Anastrozole

Arimidex

Aromatase inhibitor that controls estrogen levels during testosterone therapy

Reduces elevated estradiol durin...Can resolve gynecomastia symptom...Decreases water retention associ...
$10-30/monthFull profile
HRTStrongCompounding Legal

Enclomiphene

Enclomiphene Citrate

Selective estrogen receptor modulator that boosts testosterone while preserving fertility

Raises endogenous testosterone 2...Preserves sperm production and f...Avoids testicular atrophy seen w...
$40-120/month depending on dose and pharmacyFull profile
Growth HormoneStrongFDA Approved

Tesamorelin

Egrifta / Egrifta SV

FDA-approved GHRH analog that reduces visceral fat and improves body composition

Reduces visceral adipose tissue ...FDA-approved with well-documente...Increases IGF-1 levels by approx...
$150-450/month compounded; $3,000-6,000/month brandFull profile
HRTModerateFDA Approved

Clomiphene Citrate

Clomid, Serophene

Selective estrogen receptor modulator that raises endogenous testosterone by stimulating the HPG axis

Raises endogenous testosterone w...Preserves or improves fertility ...Oral administration (no injectio...
$15-40/monthFull profile
Weight LossStrongFDA Approved

Orforglipron

Foundayo

First oral non-peptide GLP-1 agonist: a daily pill with no food restrictions or injections

11.2% mean weight loss at 72 wee...Oral daily pill, no injections r...No food or water restrictions (f...
$25-349/month depending on insurance statusFull profile
Anti-AgingModerateCompounding Legal

NMN

Nicotinamide Mononucleotide

NAD+ precursor that restores cellular energy metabolism

Raises NAD+ levels by 40-60% in ...Improved muscle insulin sensitiv...Supports mitochondrial energy pr...
$30-100/month depending on brand, dose, and formFull profile
Weight LossModerateFDA Approved

AOD-9604

Advanced Obesity Drug 9604 / Tyr-hGH Fragment 176-191

Fat-burning peptide fragment that stimulates lipolysis without growth hormone side effects

Stimulates lipolysis without IGF...Inhibits new fat formation (lipo...No impact on insulin sensitivity...
$40-200/month depending on dose and sourceFull profile
HRTStrongFDA Approved

Testosterone Cypionate

Test Cyp

The most commonly prescribed form of testosterone replacement in the US

Restores testosterone to physiol...Increases lean muscle mass and r...Improves bone mineral density
$30-100/month depending on dose and sourceFull profile
HRTModerateCompounding Legal

Pregnenolone

Pregnenolone (3beta-hydroxypregn-5-en-20-one)

Master precursor hormone that feeds downstream production of cortisol, DHEA, testosterone, and estrogen

Supports downstream hormone prod...Enhances memory and cognitive fu...Replaces upstream hormones suppr...
$10-30/month (OTC supplement), $20-50/month (pharmaceutical grade)Full profile
HRTStrongFDA Approved

Estradiol

17-beta Estradiol (E2)

The primary estrogen used in female hormone replacement therapy

Eliminates or significantly redu...Restores vaginal moisture and ti...Prevents osteoporosis and reduce...
$20-80/month depending on formulation and sourceFull profile
HRTModerateFDA Approved

Gonadorelin

GnRH (Gonadotropin-Releasing Hormone)

Synthetic GnRH analog that stimulates natural LH and FSH production as an alternative to HCG

Maintains LH and FSH production ...Preserves testicular function an...Works through the body's own hor...
$50-150/month depending on dosage and pharmacyFull profile
Skin and HealingEmergingFDA Approved

Melanotan II

MT-II / MT-2

Melanocortin receptor agonist that produces tanning, libido enhancement, and appetite suppression

Produces skin tanning without UV...Enhances sexual arousal and erec...Suppresses appetite
$30-80 per 10 mg vial from research suppliersFull profile
Growth HormoneStrongFDA Approved

Tesamorelin

Egrifta, TH9507

FDA-approved GHRH analog that reduces visceral fat and stimulates natural growth hormone production

FDA-approved with Phase 3 clinic...Reduces visceral abdominal fat b...Preserves lean body mass
$400-800/monthFull profile
Growth HormoneModerateCompounding Legal

Ipamorelin

Selective growth hormone peptide that boosts GH without cortisol spikes

Stimulates growth hormone releas...Improves body composition by inc...Does not cause significant hunge...
$150-300/month depending on dose and providerFull profile
HRTStrongFDA Approved

Progesterone

Micronized Progesterone

The bioidentical progesterone used alongside estradiol in female HRT

Protects the uterine lining when...Improves sleep quality through G...Supports mood stability and redu...
$20-60/month depending on dose and sourceFull profile
RecoveryEmergingCompounding Legal

KPV

Lys-Pro-Val (Alpha-MSH Fragment)

Anti-inflammatory tripeptide derived from alpha-MSH that targets gut inflammation at the cellular level

Reduces intestinal inflammation ...Decreases pro-inflammatory cytok...Supports gut mucosal barrier repair
$80-180/month depending on formulation and doseFull profile
Growth HormoneModerateFDA Approved

GHRP-2

Pralmorelin / KP-102

The strongest growth hormone releasing peptide, used diagnostically in Japan for GH deficiency testing

Strongest acute GH stimulation o...54-fold GH increase when combine...Approved diagnostic agent for GH...
$20-50 per 5 mg vial from research suppliers; $100-250/month compoundedFull profile
Muscle GrowthEmergingFDA Approved

IGF-1 LR3

Long Arginine 3-IGF-1

Extended-action IGF-1 analog that activates muscle satellite cells for both hypertrophy and hyperplasia

2-3x more potent than native IGF...Up to 120x longer functional dur...Activates satellite cells for tr...
$60-120 per 1 mg vial from research suppliers; $200-400/month estimated clinic costFull profile
Growth HormoneModerateCompounding Legal

GHRP-6

Growth Hormone Releasing Peptide-6

Growth hormone secretagogue with strong appetite-stimulating effects through the ghrelin receptor

Reliable growth hormone releaseStrong appetite stimulation (use...Synergistic with GHRH analogs
$50-120/monthFull profile
Growth HormoneModerateCompounding Legal

MK-677

Ibutamoren

Oral growth hormone secretagogue that raises GH and IGF-1 levels daily

Orally administered, no injectio...Raises IGF-1 levels by 40-60% wi...Improves sleep quality, especial...
$50-150/month depending on form and providerFull profile
HRTModerateFDA Approved

DHEA

Dehydroepiandrosterone

The most abundant steroid hormone precursor in the body, declining sharply with age

Precursor to testosterone and es...May improve bone mineral density...Supports adrenal function and st...
$10-40/month for oral supplement, $200-300/month for IntrarosaFull profile
ImmuneModerateCompounding Legal

LL-37

Cathelicidin Antimicrobial Peptide

Human antimicrobial peptide that fights infections and modulates the immune response

Direct antimicrobial activity ag...Disrupts established bacterial b...Recruits immune cells to infecti...
$150-300/month depending on dosage and protocol durationFull profile
Muscle GrowthEmergingFDA Approved

Follistatin 344

FS344 / FST344

Myostatin-blocking protein that promotes muscle growth through dual anti-catabolic mechanisms

Potent myostatin inhibition prom...Dual blockade of myostatin and a...Over 20% sustained muscle mass i...
$150-360 per 30-day cycle at 100 mcg/day from research suppliersFull profile
Growth HormoneModerateFDA Approved

GHRP-6

Growth Hormone Releasing Hexapeptide

The original growth hormone releasing peptide with strong appetite stimulation and cardioprotective research

Strong GH release through ghreli...Most potent appetite stimulation...78% reduction in infarct mass in...
$15-40 per 5 mg vial from research suppliers; $80-200/month compoundedFull profile
Growth HormoneModerateCompounding Legal

GHRP-2

Growth Hormone Releasing Peptide-2, Pralmorelin

Potent growth hormone secretagogue that stimulates GH release through the ghrelin receptor

Strong growth hormone release wi...Less appetite stimulation than G...Synergistic with GHRH analogs (C...
$60-150/monthFull profile
Growth HormoneModerateCompounding Legal

CJC-1295

Modified GRF 1-29

Long-acting growth hormone releasing peptide for sustained GH elevation

Sustained elevation of growth ho...Supports muscle growth and fat m...Improves sleep quality when dose...
$150-300/month depending on version (DAC vs no-DAC) and doseFull profile
RecoveryModerateCompounding Legal

VIP

Vasoactive Intestinal Peptide

Neuropeptide that regulates inflammation, circadian rhythm, and pulmonary function

Reduces systemic inflammation th...Supports pulmonary function and ...Helps regulate disrupted circadi...
$120-250/month depending on dosage and compounding pharmacyFull profile
Growth HormoneModerateFDA Approved

Hexarelin

Examorelin

GH secretagogue with unique cardiac protective effects through CD36 receptor binding

Strongest GH release of any GHRP...Unique cardiac protection throug...Post-MI mortality: 6.7% hexareli...
$40-80 per 2 mg vial from research suppliers; $150-300/month from specialty clinicsFull profile
GrowthEmergingFDA Approved

Follistatin 344

FS-344, FST344

Myostatin inhibitor that promotes muscle growth by removing natural growth limiters

Promotes muscle growth by neutra...May improve body composition and...Supports muscle regeneration aft...
$150-400/month from research suppliersFull profile
MetabolicEmergingCompounding Legal

5-Amino-1MQ

5-Amino-1-methylquinolinium

NNMT inhibitor that shifts cellular metabolism toward fat burning and away from fat storage

Reduces fat cell size and lipid ...Increases cellular NAD+ levelsSupports metabolic rate and ener...
$100-250/monthFull profile
RecoveryEmergingCompounding Legal

TB-500

Thymosin Beta-4 Fragment

Wound healing peptide that promotes cell migration and tissue repair

Promotes rapid cell migration to...Accelerates muscle, tendon, and ...Reduces chronic and acute inflam...
$120-250/month depending on dose and providerFull profile
CognitiveEmergingFDA Approved

Dihexa

N-hexanoic-Tyr-Ile-(6) aminohexanoic amide

Potent nootropic peptide derivative that promotes synaptogenesis and cognitive enhancement

Promotes formation of new synapt...Enhanced cognitive function in a...Increases dendritic spine density
$60-150/month from research chemical suppliersFull profile
CognitiveEmergingFDA Approved

DSIP

Delta Sleep-Inducing Peptide

Sleep-normalizing nonapeptide that promotes deep delta-wave sleep without sedation

Normalizes sleep architecture wi...Promotes deep delta-wave sleepModulates HPA stress axis (lower...
$30-60 per 5 mg vial from research suppliers; $100-250/month compoundedFull profile
Weight LossModerateCompounding Legal

Tesofensine

NS2330

Triple monoamine reuptake inhibitor that produced ~10% weight loss in Phase 2 after being discovered as a Parkinson's drug side effect

9.2% placebo-subtracted weight l...Reduces both appetite and increa...Oral capsule, once daily (conven...
$90-300/month depending on dose and sourceFull profile
Growth HormoneModerateCompounding Legal

CJC-1295 with DAC

CJC-1295 DAC, Modified GRF(1-29) with Drug Affinity Complex

Long-acting GHRH analog with extended half-life for sustained growth hormone elevation

Less frequent dosing (1-2 times ...Sustained GH and IGF-1 elevation...Strong IGF-1 increase documented...
$80-200/monthFull profile
Sleep & StressEmergingFDA Approved

DSIP

Delta Sleep Inducing Peptide

Neuropeptide that promotes slow-wave sleep and modulates stress hormone response

Promotes slow-wave (delta) sleepReduces sleep latency (time to f...Modulates cortisol and stress ho...
$50-120/month from research suppliersFull profile
Sexual HealthStrongFDA Approved

PT-141

Bremelanotide

Melanocortin receptor peptide that treats sexual dysfunction in men and women

Increases sexual desire through ...Effective for both men and women...Works through a different pathwa...
$100-200/month compounded, $400-900/month brandFull profile
RecoveryModerateCompounding Legal

Thymosin Beta-4

TB4 (Full-Length Thymosin Beta-4)

Full-length tissue repair peptide that promotes cell migration, wound healing, and cardiac protection

Promotes cell migration to wound...Reduces inflammation through IL-...Cardiac protection after ischemi...
$150-350/month for full-length thymosin beta-4Full profile
Skin & HairEmergingCompounding Legal

SNAP-8

Acetyl Octapeptide-3

Topical peptide that reduces expression lines by modulating neuromuscular signaling at the skin level

Reduces depth of expression line...Non-invasive alternative to botu...No systemic side effects (topica...
$30-80/month for commercial serum productsFull profile
Anti-AgingEmergingCompounding Legal

SS-31

Elamipretide

Mitochondria-targeted peptide that restores cellular energy production

Directly targets mitochondria (1...Stabilizes cardiolipin for impro...Reduces mitochondrial reactive o...
$200-500/month depending on dose and providerFull profile
Gut HealthModerateCompounding Legal

Larazotide

Larazotide Acetate, AT-1001, INN-202

Tight junction regulator that reduces intestinal permeability and targets leaky gut at the cellular level

Directly targets the tight junct...Acts locally in the gut (not sys...Reduced gluten-induced symptoms ...
$100-250/monthFull profile
ImmuneEmergingFDA Approved

Thymulin

Facteur Thymique Serique (FTS), Serum Thymic Factor

Thymus-derived zinc-bound peptide that modulates T-cell development and immune regulation

Supports T-cell maturation and i...Anti-inflammatory effects throug...Analgesic properties demonstrate...
$80-200/month from research suppliersFull profile
Skin & HairEmergingCompounding Legal

AHK-Cu Copper Peptide

Alanine-Histidine-Lysine Copper, AHK-Cu Tripeptide

Copper-binding tripeptide that stimulates hair follicle growth factors and supports skin rejuvenation

Stimulates hair follicle dermal ...Upregulates VEGF for improved fo...May extend the anagen (growth) p...
$40-120/monthFull profile
LongevityModerateCompounding Legal

NAD+

Nicotinamide Adenine Dinucleotide

Cellular energy coenzyme critical for DNA repair and healthy aging

Restores cellular energy product...Activates sirtuins involved in D...Improves cognitive clarity and r...
$200-400/month for injectable, $30-100/month for oral precursorsFull profile
Anti-AgingEmergingCompounding Legal

Humanin

Mitochondrial-derived peptide that protects against age-related cellular stress

Neuroprotective effects against ...Protects cells from oxidative st...Improves insulin sensitivity thr...
$200-400/month depending on dose and providerFull profile
Skin and HealingModerateCompounding Legal

GHK-Cu

Copper Peptide

Copper-binding peptide that remodels skin, heals wounds, and stimulates collagen

Stimulates collagen and elastin ...Accelerates wound healing and re...Promotes hair follicle growth an...
$80-200/month depending on form and providerFull profile
LongevityEmergingCompounding Legal

Epithalon

Epitalon

Pineal peptide that activates telomerase and targets biological aging

Activates telomerase to maintain...Normalizes melatonin production ...Supports antioxidant defense sys...
$100-200 during treatment cycles, lower annualized cost due to pulsed dosingFull profile
CognitiveEmergingCompounding Legal

Selank

TP-7

Synthetic tuftsin peptide with anxiolytic and immune-boosting properties

Reduces anxiety without sedation...Enhances cognitive focus and men...Modulates immune function throug...
$80-200/month depending on form and providerFull profile
CognitiveEmergingCompounding Legal

Semax

Synthetic ACTH fragment that boosts BDNF and protects neurons

Significantly increases BDNF lev...Enhances memory formation and le...Provides neuroprotection against...
$80-200/month depending on form and providerFull profile
ImmuneStrongCompounding Legal

Thymosin Alpha-1

Ta1

Immune-regulating peptide approved in 30+ countries for infection and immune support

Enhances T cell function and mat...Activates natural killer cells a...Approved in 30+ countries for ch...
$150-350/month depending on dose and providerFull profile
HormonalModerateCompounding Legal

Kisspeptin

Kisspeptin-10 / Kisspeptin-54

Hormone-regulating peptide that drives reproductive function and GnRH release

Stimulates natural testosterone ...Potential fertility treatment fo...May serve as a diagnostic tool f...
$150-350/month depending on form and providerFull profile
MetabolicEmergingCompounding Legal

MOTS-c

Mitochondrial Open Reading Frame of the 12S rRNA Type-c

Mitochondrial peptide that mimics exercise and improves metabolic health

Activates AMPK pathway similarly...Improves insulin sensitivity and...Promotes fat oxidation and suppo...
$200-400/month depending on dose and providerFull profile

2026 regulatory changes

Peptide regulation changed significantly in February 2026 when HHS reinstated 14 previously restricted peptides for legal compounding. GLP-1 compounds remain available through compounding during ongoing shortage determinations.

FDA Approved

Full clinical trials completed. Approved for specific medical indications.

Compounding Legal

Available through registered 503A/503B pharmacies with a physician prescription.

Research Only

Not currently approved or available through standard compounding channels.

View full regulatory tracker

Evidence grading methodology

Every compound in our database receives an evidence grade based on the quality, quantity, and recency of published peer-reviewed research. Our physician team reviews and assigns grades using the following framework:

Strong Evidence

Multiple human clinical trials published in peer-reviewed journals with consistent results across study populations.

Moderate Evidence

Limited human studies combined with extensive peer-reviewed animal research showing consistent mechanisms and outcomes.

Emerging Evidence

Primarily preclinical (animal and in-vitro) studies in peer-reviewed journals. Promising mechanisms but lacking human validation.

Anecdotal

Limited published research. Based primarily on practitioner reports, case studies, and community experience.

Frequently asked questions

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Medical Disclaimer: The information on this page is for educational purposes only and is not intended as medical advice. Compound data, evidence grades, and regulatory statuses are reviewed by our physician team but should not replace professional medical consultation. Always consult a licensed healthcare provider before starting any peptide, GLP-1, or HRT therapy. Evidence grades reflect published research quality and do not guarantee individual outcomes. Regulatory statuses are subject to change; verify current legality with your provider.