MEDVi vs ShedRx: GLP-1 Program Comparison 2026

Bottom line: ShedRx and MEDVi both offer compounded GLP-1 programs, but ShedRx differentiates itself with combination protocols that pair GLP-1 medication with additional compounds like B12, levocarnitine, or other metabolic boosters. MEDVi takes a more traditional physician-led approach with thorough lab work. If you're interested in combination protocols and want to try a more aggressive metabolic approach, ShedRx offers options that MEDVi doesn't. If you prefer a straightforward, lab-backed, physician-supervised program, MEDVi is the safer bet.

Quick Comparison

Pricing Breakdown

Pricing overlaps but with different ranges. MEDVi runs $249-$399/month. ShedRx has a wider range, starting as low as $199 for basic compounded semaglutide and going up to $449 for premium combination protocols that include additional metabolic compounds.

At the low end, ShedRx is cheaper for patients who want basic compounded semaglutide without extras. At the high end, ShedRx's combination protocols can cost more than MEDVi's most expensive plan. The question is whether the combination ingredients justify the premium.

MEDVi's pricing includes thorough metabolic lab work, which adds value that ShedRx's plans don't match. ShedRx invests that portion of its budget into the medication formulations themselves rather than diagnostics.

Medications Available

This is where ShedRx stands out. Beyond standard compounded semaglutide and tirzepatide, ShedRx offers combination protocols that blend GLP-1 peptides with supporting compounds. Common additions include vitamin B12 (for energy and metabolism), levocarnitine (for fat metabolism), and in some cases, other amino acids or peptides.

The rationale behind combination protocols is that supporting compounds can reduce side effects, improve energy levels during calorie restriction, and enhance fat oxidation. Some patients report better tolerability and results with combination formulations. Others find no meaningful difference compared to standalone GLP-1 medication.

ShedRx also offers sublingual (under-the-tongue) formulations in some plans, which appeals to patients who want to avoid injections. MEDVi sticks to injectable compounded GLP-1s, which generally have more consistent absorption.

MEDVi offers a cleaner, more traditional approach: compounded GLP-1 medication prescribed within a structured, lab-monitored protocol. There's value in simplicity, especially when the evidence base for many combination additives is still developing.

Patient Experience

Both platforms use basic patient portals without the polish of larger telehealth companies. The onboarding experience differs in focus. MEDVi's intake is clinically thorough, with detailed health history review and lab orders. ShedRx's intake is more product-focused, guiding patients through medication options and combination protocol choices.

ShedRx gives patients more agency in selecting their treatment plan, which some find helping and others find overwhelming. MEDVi's approach is more physician-directed: the doctor reviews your health data and recommends a protocol, which feels more like traditional medical care.

For follow-up care, MEDVi schedules proactive check-ins. ShedRx operates more on a patient-initiated model, with messaging available for questions and concerns.

Provider Quality and Support

MEDVi uses board-certified physicians. ShedRx uses a mix of licensed providers. Both are appropriate for GLP-1 prescribing.

Where provider quality matters more than usual is with combination protocols. Mixing multiple compounds in a single injection or treatment plan requires informed clinical judgment. ShedRx's providers are trained on their specific protocols, but patients should ask questions about the evidence behind any combination they're offered. If a provider can't explain why a specific additive is included or what evidence supports it, that's a red flag regardless of platform.

MEDVi providers may be less familiar with combination approaches but bring deeper metabolic health knowledge and the backing of lab data to support clinical decisions.

Pros and Cons

MEDVi

Pros:

• Physician-led with thorough lab work
• Straightforward, evidence-based medication approach
• Proactive follow-up scheduling
• Predictable pricing

Cons:

• No combination protocol options
• No sublingual formulations
• Higher base price for basic GLP-1 access
• Less patient choice in treatment customization

ShedRx

Pros:

• Combination protocols with metabolic support compounds
• Sublingual options available for needle-averse patients
• Lower entry price for basic plans
• More treatment customization options
• Good state coverage

Cons:

• Premium combination plans are expensive
• No lab work included
• Evidence for some combination additives is limited
• Less structured clinical oversight
• Patient-initiated follow-ups

Who Should Choose MEDVi

MEDVi is the better choice for patients who prefer a traditional, physician-directed approach with metabolic lab monitoring. If you want your provider making the treatment decisions based on your bloodwork rather than choosing from a menu of combination options, MEDVi's model is more aligned with how medical care typically works.

Who Should Choose ShedRx

ShedRx is worth considering if you're drawn to combination protocols or want non-injectable options. It's also a good fit for patients who like having more control over their treatment choices. Just go in with realistic expectations about what the add-on compounds do and don't have strong evidence for.

How FormBlends Compares

FormBlends takes a physician-supervised approach that shares common ground with both platforms. Like MEDVi, every FormBlends patient works with a licensed physician. Like ShedRx, FormBlends goes beyond standalone GLP-1 therapy, offering peptide wellness protocols for recovery, energy, and metabolic improvement. The difference is that FormBlends' peptide offerings are distinct, evidence-informed protocols rather than compounded add-ins blended into a single injection. Patients interested in this model can learn more at FormBlends.com.

What MEDVi and ShedRx actually charge right now (September 2026 price index)

The prices quoted in the sections above were checked when this comparison was written. The table below is different: it is pulled from the FormBlends Compounded GLP-1 Price Index, which records the all-in cash price for a 28-day supply from each provider's public pricing page every week. These are the rows for MEDVi and ShedRx as of September 3, 2026. Month one is the starting dose (2.5 mg tirzepatide or 0.25 mg semaglutide); month four is the first maintenance step (5 mg or 1 mg).

For context, the index median for compounded tirzepatide at month one was $299 across 14 providers on September 3, 2026, and $197 for compounded semaglutide. Brand Zepbound through LillyDirect was $299 to $449 and the Wegovy pen $199 for the first two fills, then $349. The full dataset, methodology and a CSV download are at the Compounded GLP-1 Price Index, where FormBlends is listed under the same rules as every other provider.

Frequently Asked Questions

Are ShedRx combination protocols safe?

The individual ingredients (B12, levocarnitine, etc.) are well-established and generally safe. The combination with GLP-1 peptides is less studied in rigorous clinical trials. ShedRx's protocols are prescribed by licensed providers and dispensed by licensed pharmacies, but patients should understand that combination formulations don't have the same evidence base as standalone GLP-1 medications.

Do sublingual GLP-1 formulations work as well as injections?

The evidence suggests injectable GLP-1 formulations have more reliable bioavailability (absorption into the bloodstream). Sublingual formulations are convenient and avoid needles, but absorption can be more variable. If maximizing medication effectiveness is your priority, injections are the more proven route.

Does MEDVi offer any add-on treatments?

MEDVi focuses on compounded GLP-1 medication within a metabolic health framework. It doesn't offer combination protocols or supplementary compounds in the way ShedRx does. MEDVi providers may recommend supplements or lifestyle changes but don't compound them into the medication itself.

Can I start with ShedRx's basic plan and upgrade later?

Yes. ShedRx allows patients to start with a standard compounded semaglutide plan and upgrade to combination protocols during subsequent consultations. This lets you try the base medication first and add compounds only if you feel you need additional support.

Interested in physician-supervised GLP-1 therapy paired with dedicated peptide wellness protocols? Explore FormBlends and see how the approach works.