Compare GLP-1 Compounds
See how our GLP-1 peptides stack up against each other so you can choose the right compound for your goals.
 Semaglutide | Most Effective Tirzepatide |  Liraglutide |  AOD-9604 |  Retatrutide |  Cagrilintide | |
|---|---|---|---|---|---|---|
| Price | $299$449 5mg vial | $349$549 5mg vial | $199$299 3mg vial | $89$129 5mg vial | $389$599 6mg vial | $279$399 10mg vial |
| Rating | 4.9★★★★★ 2,847 reviews | 4.9★★★★★ 1,923 reviews | 4.7★★★★★ 1,456 reviews | 4.6★★★★★ 834 reviews | 4.9★★★★★ 647 reviews | 4.7★★★★★ 312 reviews |
| Mechanism of Action | GLP-1 receptor agonist | Dual GIP/GLP-1 receptor agonist | GLP-1 receptor agonist | hGH fragment 176-191 (lipolytic) | ||
| Avg. Weight Loss | Up to 15% | Up to 22.5% | 5-8% | Targeted fat reduction | ||
| Dosing Frequency | Once weekly | Once weekly | Daily | Daily | ||
| Purity | 99.1% | 99.3% | 98.9% | 99.0% | 99.2% | 99.1% |
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Semaglutide
$299$449
5mg vial
4.9★★★★★(2,847)
MechanismGLP-1 receptor agonist
Avg. Weight LossUp to 15%
DosingOnce weekly
Purity99.1%
Key Benefits
- 14.9% mean body weight reduction demonstrated in STEP 1 trial (N=1,961)
- 20% reduction in major adverse cardiovascular events in SELECT trial (N=17,604)
- Significant reduction in appetite and food cravings via hypothalamic POMC/CART activation
- Improved glycemic control with glucose-dependent insulin secretion potentiation
Most EffectiveView Product
Tirzepatide
$349$549
5mg vial
4.9★★★★★(1,923)
MechanismDual GIP/GLP-1 receptor agonist
Avg. Weight LossUp to 22.5%
DosingOnce weekly
Purity99.3%
Key Benefits
- 22.5% mean body weight reduction at 15mg in SURMOUNT-1 (N=2,539, 72 weeks)
- Dual GIP/GLP-1 receptor activation for combined metabolic effects beyond single-agonist therapy
- 63% of participants at highest dose achieved at least 20% weight loss vs 1.3% placebo
- Superior A1C reduction of 2.07-2.59% with up to 97% of diabetic participants reaching target
Liraglutide
$199$299
3mg vial
4.7★★★★★(1,456)
MechanismGLP-1 receptor agonist
Avg. Weight Loss5-8%
DosingDaily
Purity98.9%
Key Benefits
- 8.0% mean body weight reduction in SCALE trial (N=3,731) over 56 weeks
- 79% reduction in progression from prediabetes to type 2 diabetes during treatment
- 13% MACE reduction in LEADER cardiovascular outcomes trial (N=9,340, median 3.8 years)
- Over a decade of post-market safety data across millions of patients worldwide
AOD-9604
$89$129
5mg vial
4.6★★★★★(834)
MechanismhGH fragment 176-191 (lipolytic)
Avg. Weight LossTargeted fat reduction
DosingDaily
Purity99.0%
Key Benefits
- Targeted fat metabolism via beta-3 adrenergic receptor activation without hGH side effects
- Stimulates hormone-sensitive lipase for direct triglyceride release from adipocytes (lipolysis)
- Inhibits lipogenesis by downregulating ACC and fatty acid synthase in fat tissue
- No impact on IGF-1 levels, glucose tolerance, insulin sensitivity, or bone growth
Retatrutide
$389$599
6mg vial
4.9★★★★★(647)
Mechanism
Avg. Weight Loss
Dosing
Purity99.2%
Key Benefits
- 24.2% mean body weight reduction at 12mg in Phase 2 trial (N=338, 48 weeks) -- highest ever recorded
- Triple GLP-1R/GIPR/GCGR activation engages appetite suppression, fat handling, and energy expenditure simultaneously
- 100% of participants at highest dose achieved at least 5% weight loss; 83% achieved at least 15%
- 82.4% mean liver fat reduction with 86% achieving complete MASLD resolution (below 5% liver fat)
Cagrilintide
$279$399
10mg vial
4.7★★★★★(312)
Mechanism
Avg. Weight Loss
Dosing
Purity99.1%
Key Benefits
- 10.8% weight loss as monotherapy in Phase 2 (N=92, 26 weeks) via amylin receptor activation
- CagriSema combination achieved 22.7% weight loss vs 15.8% semaglutide alone in REDEFINE 1
- Targets brainstem amylin receptors (CTR/RAMP complexes) -- pharmacologically distinct from GLP-1 pathway
- Additive appetite suppression when combined with GLP-1 agonists through non-overlapping neural circuits
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