This page is not medical advice. Selank is not FDA-approved. Consult a licensed clinician before use.
Making a Selank nasal spray involves more than dissolving a stated amount of powder. Concentration, the liquid delivered by the pump, the formulation and its tested storage period are separate questions. The sources below establish some of those facts, but they do not validate a universal homemade recipe.
Concentration and amount per spray
Concentration is the amount divided by final liquid volume. Amount per actuation is concentration multiplied by the liquid volume actually delivered in that actuation. These equations describe quantities; they do not select a formulation or establish a clinical regimen.
| Stated concentration | Stated delivered volume | Calculated amount |
|---|---|---|
| 1.5 mg/mL | 0.1 mL | 0.15 mg, or 150 mcg |
| 1.5 mg/mL | 0.05 mL | 0.075 mg, or 75 mcg |
| 3 mg/mL | 0.1 mL | 0.3 mg, or 300 mcg |
The table shows why a concentration alone does not tell you the amount in a spray. The same solution gives different calculated amounts when delivered volume changes. Conversely, two different solutions can produce the same amount if their device outputs differ. These are arithmetic examples, not recommended targets.
What 0.15% means
If a solution is specified as 0.15% weight per volume, it contains 0.15 g per 100 mL. Converting grams to milligrams gives 150 mg per 100 mL, or 1.5 mg/mL. That notation still leaves pump output and formulation properties unspecified. It does not describe a number of sprays or establish equivalence between a commercial preparation and a powder mixed separately.
Why an injection diluent label does not validate a nasal formula
Hospira's Bacteriostatic Water for Injection label describes a diluent for intravenous, intramuscular or subcutaneous drugs. The product contains a benzyl-alcohol preservative. Its specified uses do not include making a Selank nasal spray, and the label supplies no Selank nasal stability or beyond-use study. A preservative listed for an injection vehicle is therefore not evidence for the earlier claim that it is the preferred nasal diluent.
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Aptar describes its CPS nasal platform as a formulation-and-device system with controlled spray characteristics and predominantly non-inhalable droplets. Those properties belong to a tested system. A generic bottle described as a nasal atomizer does not inherit the same delivered-dose performance. Nominal bottle capacity, liquid concentration and delivered volume are three different measurements.
What the human Selank report establishes
A 2008 report included 62 patients with generalized anxiety disorder or neurasthenia, comparing 30 receiving Selank with 32 receiving medazepam. It reported psychometric and biological outcomes. That report addresses an intervention in a defined clinical setting. Its abstract does not establish that a homemade nasal solution, a different pump or an arbitrary storage period reproduces the intervention or its outcomes.
Stability and storage
A four-week refrigerator life cannot be inferred from the presence of a preservative. A formulation-specific storage claim needs chemical stability, microbiological performance, packaging compatibility and delivered-dose data over the proposed period. The cited sources do not establish a four-week storage specification for Selank mixed in bacteriostatic water. Refrigeration temperature alone is not a substitute for those measurements.
FAQ
Does 0.15% mean 150 mcg per spray?
It means 1.5 mg/mL when the percentage is weight per volume. It gives 150 mcg only if the delivered liquid volume is 0.1 mL.
Does adding a preservative establish the shelf life?
No. Preservative content and validated storage performance are different properties. The relevant evidence must match the formulation and container.
Can the concentration be checked mathematically?
Yes. Divide the stated amount by final solution volume, then multiply by delivered volume. This checks the arithmetic without establishing the composition, pump performance or studied regimen.
Sources
- 2008 Selank clinical report: population, comparator and measured outcomes
- Hospira Bacteriostatic Water for Injection labeling
- Aptar CPS nasal delivery platform
- NIST volume units
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